Generation of an integration-free induced pluripotent stem cell line (CSC-43) from a patient with sporadic Parkinson's disease

Detalhes bibliográficos
Autor(a) principal: Marote, A
Data de Publicação: 2018
Outros Autores: Pomeshchik, Y, Goldwurm, S, Collin, A, Lamas, NJ, Pinto, L, Salgado, AJ, Roybon, L
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.23/1242
Resumo: An induced pluripotent stem cell (iPSC) line was generated from a 36-year-old patient with sporadic Parkinson's disease (PD). Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated cell line (CSC-43) exhibits expression of common pluripotency markers, in vitro differentiation into three germ layers and normal karyotype. This iPSC line can be used to study the mechanisms underlying the development of PD.
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spelling Generation of an integration-free induced pluripotent stem cell line (CSC-43) from a patient with sporadic Parkinson's diseaseCélulas-Tronco Pluripotentes InduzidasDoença de ParkinsonAn induced pluripotent stem cell (iPSC) line was generated from a 36-year-old patient with sporadic Parkinson's disease (PD). Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated cell line (CSC-43) exhibits expression of common pluripotency markers, in vitro differentiation into three germ layers and normal karyotype. This iPSC line can be used to study the mechanisms underlying the development of PD.Repositório Científico do Hospital de BragaMarote, APomeshchik, YGoldwurm, SCollin, ALamas, NJPinto, LSalgado, AJRoybon, L2018-02-16T14:22:26Z2018-01-04T00:00:00Z2018-01-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.23/1242engStem Cell Res. 2018 Jan 4;27:82-8510.1016/j.scr.2018.01.007info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-21T09:03:08Zoai:repositorio.hospitaldebraga.pt:10400.23/1242Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:55:46.905421Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Generation of an integration-free induced pluripotent stem cell line (CSC-43) from a patient with sporadic Parkinson's disease
title Generation of an integration-free induced pluripotent stem cell line (CSC-43) from a patient with sporadic Parkinson's disease
spellingShingle Generation of an integration-free induced pluripotent stem cell line (CSC-43) from a patient with sporadic Parkinson's disease
Marote, A
Células-Tronco Pluripotentes Induzidas
Doença de Parkinson
title_short Generation of an integration-free induced pluripotent stem cell line (CSC-43) from a patient with sporadic Parkinson's disease
title_full Generation of an integration-free induced pluripotent stem cell line (CSC-43) from a patient with sporadic Parkinson's disease
title_fullStr Generation of an integration-free induced pluripotent stem cell line (CSC-43) from a patient with sporadic Parkinson's disease
title_full_unstemmed Generation of an integration-free induced pluripotent stem cell line (CSC-43) from a patient with sporadic Parkinson's disease
title_sort Generation of an integration-free induced pluripotent stem cell line (CSC-43) from a patient with sporadic Parkinson's disease
author Marote, A
author_facet Marote, A
Pomeshchik, Y
Goldwurm, S
Collin, A
Lamas, NJ
Pinto, L
Salgado, AJ
Roybon, L
author_role author
author2 Pomeshchik, Y
Goldwurm, S
Collin, A
Lamas, NJ
Pinto, L
Salgado, AJ
Roybon, L
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Hospital de Braga
dc.contributor.author.fl_str_mv Marote, A
Pomeshchik, Y
Goldwurm, S
Collin, A
Lamas, NJ
Pinto, L
Salgado, AJ
Roybon, L
dc.subject.por.fl_str_mv Células-Tronco Pluripotentes Induzidas
Doença de Parkinson
topic Células-Tronco Pluripotentes Induzidas
Doença de Parkinson
description An induced pluripotent stem cell (iPSC) line was generated from a 36-year-old patient with sporadic Parkinson's disease (PD). Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated cell line (CSC-43) exhibits expression of common pluripotency markers, in vitro differentiation into three germ layers and normal karyotype. This iPSC line can be used to study the mechanisms underlying the development of PD.
publishDate 2018
dc.date.none.fl_str_mv 2018-02-16T14:22:26Z
2018-01-04T00:00:00Z
2018-01-04T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.23/1242
url http://hdl.handle.net/10400.23/1242
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Stem Cell Res. 2018 Jan 4;27:82-85
10.1016/j.scr.2018.01.007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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