Potentiometric Determination of Amlodipine Besilate and Valsartan Using Microsized and Polymeric Matrix Membrane Sensors
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042012000100002 |
Resumo: | Two poly(vinyl chloride) matrix membrane electrodes responsive to some drugs affecting the cardiovascular system, Amlodipine besilate (AM) and Valsartan (VL), were developed, described and characterized. A microsized graphite selective sensor was investigated with dibutylsebacate (DBS) as a plasticizer in a polymeric matrix of carboxylated polyvinyl chloride (PVC-COOH) in case of (sensor 1). This sensor 1 was prepared using 2-hydroxy propyl β-cyclodextrin (2HP β-CD) as an ionophore. While sensor 2 preparation was based on precipitation technique with bathophenanthroline iron (II) as electroactive materials in poly(vinyl chloride) (PVC) matrix. Fast and stable Nernstian responses near 1×10-5 - 1×10-3 M for the two drugs over the pH range 3-6 and 7-9 for the two sensors, respectively, were obtained. The method was successively applied for the determination of AM and VL in presence of each others, in their pharmaceutical formulations and in human plasma samples. The percentages recoveries for the determination of the drugs by the proposed selective electrodes were 99.78 ± 0.38 %, 100.23 ± 0.44 %, for sensors 1 and 2, respectively. Statistical comparison between the results obtained by this method and those obtained by the official method and the reported method of the drugs was done and no significant difference was found. |
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Potentiometric Determination of Amlodipine Besilate and Valsartan Using Microsized and Polymeric Matrix Membrane Sensorsamlodipine besilatevalsartanmicro sensorshuman plasmaTwo poly(vinyl chloride) matrix membrane electrodes responsive to some drugs affecting the cardiovascular system, Amlodipine besilate (AM) and Valsartan (VL), were developed, described and characterized. A microsized graphite selective sensor was investigated with dibutylsebacate (DBS) as a plasticizer in a polymeric matrix of carboxylated polyvinyl chloride (PVC-COOH) in case of (sensor 1). This sensor 1 was prepared using 2-hydroxy propyl β-cyclodextrin (2HP β-CD) as an ionophore. While sensor 2 preparation was based on precipitation technique with bathophenanthroline iron (II) as electroactive materials in poly(vinyl chloride) (PVC) matrix. Fast and stable Nernstian responses near 1×10-5 - 1×10-3 M for the two drugs over the pH range 3-6 and 7-9 for the two sensors, respectively, were obtained. The method was successively applied for the determination of AM and VL in presence of each others, in their pharmaceutical formulations and in human plasma samples. The percentages recoveries for the determination of the drugs by the proposed selective electrodes were 99.78 ± 0.38 %, 100.23 ± 0.44 %, for sensors 1 and 2, respectively. Statistical comparison between the results obtained by this method and those obtained by the official method and the reported method of the drugs was done and no significant difference was found.Sociedade Portuguesa de Electroquímica2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042012000100002Portugaliae Electrochimica Acta v.30 n.1 2012reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042012000100002Ramadan,Nesrin K.Mohamed,Heba M.Mostafa,Azza A.info:eu-repo/semantics/openAccess2024-02-06T17:07:09Zoai:scielo:S0872-19042012000100002Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:20:11.769279Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Potentiometric Determination of Amlodipine Besilate and Valsartan Using Microsized and Polymeric Matrix Membrane Sensors |
title |
Potentiometric Determination of Amlodipine Besilate and Valsartan Using Microsized and Polymeric Matrix Membrane Sensors |
spellingShingle |
Potentiometric Determination of Amlodipine Besilate and Valsartan Using Microsized and Polymeric Matrix Membrane Sensors Ramadan,Nesrin K. amlodipine besilate valsartan micro sensors human plasma |
title_short |
Potentiometric Determination of Amlodipine Besilate and Valsartan Using Microsized and Polymeric Matrix Membrane Sensors |
title_full |
Potentiometric Determination of Amlodipine Besilate and Valsartan Using Microsized and Polymeric Matrix Membrane Sensors |
title_fullStr |
Potentiometric Determination of Amlodipine Besilate and Valsartan Using Microsized and Polymeric Matrix Membrane Sensors |
title_full_unstemmed |
Potentiometric Determination of Amlodipine Besilate and Valsartan Using Microsized and Polymeric Matrix Membrane Sensors |
title_sort |
Potentiometric Determination of Amlodipine Besilate and Valsartan Using Microsized and Polymeric Matrix Membrane Sensors |
author |
Ramadan,Nesrin K. |
author_facet |
Ramadan,Nesrin K. Mohamed,Heba M. Mostafa,Azza A. |
author_role |
author |
author2 |
Mohamed,Heba M. Mostafa,Azza A. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Ramadan,Nesrin K. Mohamed,Heba M. Mostafa,Azza A. |
dc.subject.por.fl_str_mv |
amlodipine besilate valsartan micro sensors human plasma |
topic |
amlodipine besilate valsartan micro sensors human plasma |
description |
Two poly(vinyl chloride) matrix membrane electrodes responsive to some drugs affecting the cardiovascular system, Amlodipine besilate (AM) and Valsartan (VL), were developed, described and characterized. A microsized graphite selective sensor was investigated with dibutylsebacate (DBS) as a plasticizer in a polymeric matrix of carboxylated polyvinyl chloride (PVC-COOH) in case of (sensor 1). This sensor 1 was prepared using 2-hydroxy propyl β-cyclodextrin (2HP β-CD) as an ionophore. While sensor 2 preparation was based on precipitation technique with bathophenanthroline iron (II) as electroactive materials in poly(vinyl chloride) (PVC) matrix. Fast and stable Nernstian responses near 1×10-5 - 1×10-3 M for the two drugs over the pH range 3-6 and 7-9 for the two sensors, respectively, were obtained. The method was successively applied for the determination of AM and VL in presence of each others, in their pharmaceutical formulations and in human plasma samples. The percentages recoveries for the determination of the drugs by the proposed selective electrodes were 99.78 ± 0.38 %, 100.23 ± 0.44 %, for sensors 1 and 2, respectively. Statistical comparison between the results obtained by this method and those obtained by the official method and the reported method of the drugs was done and no significant difference was found. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042012000100002 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042012000100002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042012000100002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Electroquímica |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Electroquímica |
dc.source.none.fl_str_mv |
Portugaliae Electrochimica Acta v.30 n.1 2012 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799137290472128512 |