Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/129004 |
Resumo: | Funding Information: The PREVIEW consortium would like to thank all the study participants at all intervention centers for their time and commitment and all scientists, advisors, and students for their dedication and contributions to the study. Specifically, we would like to thank Louise Dye (chairman of the Scientific Advisory Board, SAB), University of Leeds, UK, Richard Atkinson (Ethical Officer of the SAB), Virginia Commonwealth University, USA, and medical expert and consultant Stephen Colagiuri (University of Sydney, Australia). Meyers Madhus A/S is acknowledged for providing training and producing 2 cooking books. Furthermore, we gratefully thank the research staff from each center. From UCPH: Laura Pastor-Sanz, Grith M?ller, Lone Vestergaard Nielsen, Kasper Nowak, Arne Astrup, Finn Sand?-Pedersen, Morten Bo Johansen, Ulla Skovb?ch Pedersen, Maria Roed Andersen, Marianne Juhl Hansen, Jane J?rgensen, Sofie Skov Frost, and Lene Stevner. From HEL: Heikki Tikkanen, Saara Kettunen, Tiia Kunnas, Sanna Ritola, Laura Korpip??, Heini Hyv?rinen, Karoliina Himanen, Tiina Pellinen, Elina Malkam?ki, Heidi Jokinen, Pauliina Kokkonen, Liisi Korhonen, Jaana Valkeap??, Heli Pikkarainen, Martta Nieminen, Tuulia Ingman, Pihla M?kinen, and Sonja Toijonen. From UNOTT: Clare Randall, Nicky Gilbert, Shelley Archer, Sally Maitland, Melanie Marshall, Cheryl Percival, Jakki Pritchard, Laura Helm, and Peter Mansell. From UNAV: Blanca Martinez de Morentin, Maria Hernandez Ruiz de Eguilaz, Salome Perez Diez, Veronica Ciaurriz, Angels Batlle, and Maria Jose Cobo. From MU: Georgi Bogdanov, Pavlina Gateva, Rossica Metodieva, and Galia Dobrevska. From SU: Nils Swindell, Jeff Stephens, Gareth Dunseath, Steve Luzio, and Masoumeh Minou. From THL: Jouko Soundvall, Laura Ram?n, Merja Tukiainen, Ira Greinert, Laura Karjalainen, and Jukka Lauronen. From UNSYD: Fiona Atkinson, Michele Whittle, Jessica Burke, Kylie Simpson, Kimberley Way, Sally McClintock, Radhika Seimon, Shelly Keating, Kirsten Bell, Tania Markovic, Cathy Corry, Evalyn Eldering, and Ian Caterson. From UOA: Lindsay Plank, Nicholas Gant, Jon Woodhead, Anne-Thea McGill, Katya Volkova, Madhavi Bollineni, Clarence Vivar, Kelly Storey, Niamh Brennan, and Audrey Tay. Publisher Copyright: Copyright © 2021 Navas-Carretero, San-Cristobal, Siig Vestentoft, Brand-Miller, Jalo, Westerterp-Plantenga, Simpson, Handjieva-Darlenska, Stratton, Huttunen-Lenz, Lam, Muirhead, Poppitt, Pietiläinen, Adam, Taylor, Handjiev, McNarry, Hansen, Brodie, Silvestre, Macdonald, Boyadjieva, Mackintosh, Schlicht, Liu, Larsen, Fogelholm, Raben and Martinez. |
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Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle InterventionA Controlled Post-hoc Trialcarbohydrate metabolismdiabeteshypertriglyceridemic-waist phenotypelipid markersobesitypre-diabetesprecision nutritiontriglycerides (PubChem CID: 5460048)Food ScienceEndocrinology, Diabetes and MetabolismNutrition and DieteticsSDG 3 - Good Health and Well-beingFunding Information: The PREVIEW consortium would like to thank all the study participants at all intervention centers for their time and commitment and all scientists, advisors, and students for their dedication and contributions to the study. Specifically, we would like to thank Louise Dye (chairman of the Scientific Advisory Board, SAB), University of Leeds, UK, Richard Atkinson (Ethical Officer of the SAB), Virginia Commonwealth University, USA, and medical expert and consultant Stephen Colagiuri (University of Sydney, Australia). Meyers Madhus A/S is acknowledged for providing training and producing 2 cooking books. Furthermore, we gratefully thank the research staff from each center. From UCPH: Laura Pastor-Sanz, Grith M?ller, Lone Vestergaard Nielsen, Kasper Nowak, Arne Astrup, Finn Sand?-Pedersen, Morten Bo Johansen, Ulla Skovb?ch Pedersen, Maria Roed Andersen, Marianne Juhl Hansen, Jane J?rgensen, Sofie Skov Frost, and Lene Stevner. From HEL: Heikki Tikkanen, Saara Kettunen, Tiia Kunnas, Sanna Ritola, Laura Korpip??, Heini Hyv?rinen, Karoliina Himanen, Tiina Pellinen, Elina Malkam?ki, Heidi Jokinen, Pauliina Kokkonen, Liisi Korhonen, Jaana Valkeap??, Heli Pikkarainen, Martta Nieminen, Tuulia Ingman, Pihla M?kinen, and Sonja Toijonen. From UNOTT: Clare Randall, Nicky Gilbert, Shelley Archer, Sally Maitland, Melanie Marshall, Cheryl Percival, Jakki Pritchard, Laura Helm, and Peter Mansell. From UNAV: Blanca Martinez de Morentin, Maria Hernandez Ruiz de Eguilaz, Salome Perez Diez, Veronica Ciaurriz, Angels Batlle, and Maria Jose Cobo. From MU: Georgi Bogdanov, Pavlina Gateva, Rossica Metodieva, and Galia Dobrevska. From SU: Nils Swindell, Jeff Stephens, Gareth Dunseath, Steve Luzio, and Masoumeh Minou. From THL: Jouko Soundvall, Laura Ram?n, Merja Tukiainen, Ira Greinert, Laura Karjalainen, and Jukka Lauronen. From UNSYD: Fiona Atkinson, Michele Whittle, Jessica Burke, Kylie Simpson, Kimberley Way, Sally McClintock, Radhika Seimon, Shelly Keating, Kirsten Bell, Tania Markovic, Cathy Corry, Evalyn Eldering, and Ian Caterson. From UOA: Lindsay Plank, Nicholas Gant, Jon Woodhead, Anne-Thea McGill, Katya Volkova, Madhavi Bollineni, Clarence Vivar, Kelly Storey, Niamh Brennan, and Audrey Tay. Publisher Copyright: Copyright © 2021 Navas-Carretero, San-Cristobal, Siig Vestentoft, Brand-Miller, Jalo, Westerterp-Plantenga, Simpson, Handjieva-Darlenska, Stratton, Huttunen-Lenz, Lam, Muirhead, Poppitt, Pietiläinen, Adam, Taylor, Handjiev, McNarry, Hansen, Brodie, Silvestre, Macdonald, Boyadjieva, Mackintosh, Schlicht, Liu, Larsen, Fogelholm, Raben and Martinez.Background: Individuals with pre-diabetes are commonly overweight and benefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose index {TyG = Ln [TG (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2]} and the hypertriglyceridemic-high waist phenotype (TyG-waist), based on TyG x waist circumference (WC) measurements. Both indices may be useful for implementing personalized metabolic management. In this secondary analysis of a randomized controlled trial (RCT), we aimed to determine whether the differences in baseline TyG values and TyG-waist phenotype predicted individual responses to type-2 diabetes (T2D) prevention programs. Methods: The present post-hoc analyses were conducted within the Prevention of Diabetes through Lifestyle intervention and population studies in Europe and around the world (PREVIEW) study completers (n = 899), a multi-center RCT conducted in eight countries (NCT01777893). The study aimed to reduce the incidence of T2D in a population with pre-diabetes during a 3-year randomized intervention with two sequential phases. The first phase was a 2-month weight loss intervention to achieve ≥8% weight loss. The second phase was a 34-month weight loss maintenance intervention with two diets providing different amounts of protein and different glycemic indices, and two physical activity programs with different exercise intensities in a 2 x 2 factorial design. On investigation days, we assessed anthropometrics, glucose/lipid metabolism markers, and diet and exercise questionnaires under standardized procedures. Results: Diabetes-related markers improved during all four lifestyle interventions. Higher baseline TyG index (p < 0.001) was associated with greater reductions in body weight, fasting glucose, and triglyceride (TG), while a high TyG-waist phenotype predicted better TG responses, particularly in those randomized to physical activity (PA) of moderate intensity. Conclusions: Two novel indices of insulin resistance (TyG and TyG-waist) may allow for a more personalized approach to avoiding progression to T2D. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT01777893 reference, identifier: NCT01777893.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNNavas-Carretero, SantiagoSan-Cristobal, RodrigoSiig Vestentoft, PiaBrand-Miller, Jennie C.Jalo, ElliWesterterp-Plantenga, MargrietSimpson, Elizabeth J.Handjieva-Darlenska, TeodoraStratton, GarethHuttunen-Lenz, MaijaLam, TonyMuirhead, RoslynPoppitt, SallyPietiläinen, Kirsi H.Adam, TanjaTaylor, Moira A.Handjiev, SvetoslavMcNarry, Melitta A.Hansen, SylviaBrodie, ShannonSilvestre, Marta P.Macdonald, Ian A.Boyadjieva, NadkaMackintosh, Kelly A.Schlicht, WolfgangLiu, AmyLarsen, Thomas M.Fogelholm, MikaelRaben, AnneMartinez, J. Alfredo2021-12-10T23:38:26Z2021-11-012021-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/129004eng2296-861XPURE: 35038807https://doi.org/10.3389/fnut.2021.733697info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:08:17Zoai:run.unl.pt:10362/129004Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:46:26.720310Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention A Controlled Post-hoc Trial |
title |
Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention |
spellingShingle |
Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention Navas-Carretero, Santiago carbohydrate metabolism diabetes hypertriglyceridemic-waist phenotype lipid markers obesity pre-diabetes precision nutrition triglycerides (PubChem CID: 5460048) Food Science Endocrinology, Diabetes and Metabolism Nutrition and Dietetics SDG 3 - Good Health and Well-being |
title_short |
Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention |
title_full |
Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention |
title_fullStr |
Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention |
title_full_unstemmed |
Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention |
title_sort |
Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention |
author |
Navas-Carretero, Santiago |
author_facet |
Navas-Carretero, Santiago San-Cristobal, Rodrigo Siig Vestentoft, Pia Brand-Miller, Jennie C. Jalo, Elli Westerterp-Plantenga, Margriet Simpson, Elizabeth J. Handjieva-Darlenska, Teodora Stratton, Gareth Huttunen-Lenz, Maija Lam, Tony Muirhead, Roslyn Poppitt, Sally Pietiläinen, Kirsi H. Adam, Tanja Taylor, Moira A. Handjiev, Svetoslav McNarry, Melitta A. Hansen, Sylvia Brodie, Shannon Silvestre, Marta P. Macdonald, Ian A. Boyadjieva, Nadka Mackintosh, Kelly A. Schlicht, Wolfgang Liu, Amy Larsen, Thomas M. Fogelholm, Mikael Raben, Anne Martinez, J. Alfredo |
author_role |
author |
author2 |
San-Cristobal, Rodrigo Siig Vestentoft, Pia Brand-Miller, Jennie C. Jalo, Elli Westerterp-Plantenga, Margriet Simpson, Elizabeth J. Handjieva-Darlenska, Teodora Stratton, Gareth Huttunen-Lenz, Maija Lam, Tony Muirhead, Roslyn Poppitt, Sally Pietiläinen, Kirsi H. Adam, Tanja Taylor, Moira A. Handjiev, Svetoslav McNarry, Melitta A. Hansen, Sylvia Brodie, Shannon Silvestre, Marta P. Macdonald, Ian A. Boyadjieva, Nadka Mackintosh, Kelly A. Schlicht, Wolfgang Liu, Amy Larsen, Thomas M. Fogelholm, Mikael Raben, Anne Martinez, J. Alfredo |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Navas-Carretero, Santiago San-Cristobal, Rodrigo Siig Vestentoft, Pia Brand-Miller, Jennie C. Jalo, Elli Westerterp-Plantenga, Margriet Simpson, Elizabeth J. Handjieva-Darlenska, Teodora Stratton, Gareth Huttunen-Lenz, Maija Lam, Tony Muirhead, Roslyn Poppitt, Sally Pietiläinen, Kirsi H. Adam, Tanja Taylor, Moira A. Handjiev, Svetoslav McNarry, Melitta A. Hansen, Sylvia Brodie, Shannon Silvestre, Marta P. Macdonald, Ian A. Boyadjieva, Nadka Mackintosh, Kelly A. Schlicht, Wolfgang Liu, Amy Larsen, Thomas M. Fogelholm, Mikael Raben, Anne Martinez, J. Alfredo |
dc.subject.por.fl_str_mv |
carbohydrate metabolism diabetes hypertriglyceridemic-waist phenotype lipid markers obesity pre-diabetes precision nutrition triglycerides (PubChem CID: 5460048) Food Science Endocrinology, Diabetes and Metabolism Nutrition and Dietetics SDG 3 - Good Health and Well-being |
topic |
carbohydrate metabolism diabetes hypertriglyceridemic-waist phenotype lipid markers obesity pre-diabetes precision nutrition triglycerides (PubChem CID: 5460048) Food Science Endocrinology, Diabetes and Metabolism Nutrition and Dietetics SDG 3 - Good Health and Well-being |
description |
Funding Information: The PREVIEW consortium would like to thank all the study participants at all intervention centers for their time and commitment and all scientists, advisors, and students for their dedication and contributions to the study. Specifically, we would like to thank Louise Dye (chairman of the Scientific Advisory Board, SAB), University of Leeds, UK, Richard Atkinson (Ethical Officer of the SAB), Virginia Commonwealth University, USA, and medical expert and consultant Stephen Colagiuri (University of Sydney, Australia). Meyers Madhus A/S is acknowledged for providing training and producing 2 cooking books. Furthermore, we gratefully thank the research staff from each center. From UCPH: Laura Pastor-Sanz, Grith M?ller, Lone Vestergaard Nielsen, Kasper Nowak, Arne Astrup, Finn Sand?-Pedersen, Morten Bo Johansen, Ulla Skovb?ch Pedersen, Maria Roed Andersen, Marianne Juhl Hansen, Jane J?rgensen, Sofie Skov Frost, and Lene Stevner. From HEL: Heikki Tikkanen, Saara Kettunen, Tiia Kunnas, Sanna Ritola, Laura Korpip??, Heini Hyv?rinen, Karoliina Himanen, Tiina Pellinen, Elina Malkam?ki, Heidi Jokinen, Pauliina Kokkonen, Liisi Korhonen, Jaana Valkeap??, Heli Pikkarainen, Martta Nieminen, Tuulia Ingman, Pihla M?kinen, and Sonja Toijonen. From UNOTT: Clare Randall, Nicky Gilbert, Shelley Archer, Sally Maitland, Melanie Marshall, Cheryl Percival, Jakki Pritchard, Laura Helm, and Peter Mansell. From UNAV: Blanca Martinez de Morentin, Maria Hernandez Ruiz de Eguilaz, Salome Perez Diez, Veronica Ciaurriz, Angels Batlle, and Maria Jose Cobo. From MU: Georgi Bogdanov, Pavlina Gateva, Rossica Metodieva, and Galia Dobrevska. From SU: Nils Swindell, Jeff Stephens, Gareth Dunseath, Steve Luzio, and Masoumeh Minou. From THL: Jouko Soundvall, Laura Ram?n, Merja Tukiainen, Ira Greinert, Laura Karjalainen, and Jukka Lauronen. From UNSYD: Fiona Atkinson, Michele Whittle, Jessica Burke, Kylie Simpson, Kimberley Way, Sally McClintock, Radhika Seimon, Shelly Keating, Kirsten Bell, Tania Markovic, Cathy Corry, Evalyn Eldering, and Ian Caterson. From UOA: Lindsay Plank, Nicholas Gant, Jon Woodhead, Anne-Thea McGill, Katya Volkova, Madhavi Bollineni, Clarence Vivar, Kelly Storey, Niamh Brennan, and Audrey Tay. Publisher Copyright: Copyright © 2021 Navas-Carretero, San-Cristobal, Siig Vestentoft, Brand-Miller, Jalo, Westerterp-Plantenga, Simpson, Handjieva-Darlenska, Stratton, Huttunen-Lenz, Lam, Muirhead, Poppitt, Pietiläinen, Adam, Taylor, Handjiev, McNarry, Hansen, Brodie, Silvestre, Macdonald, Boyadjieva, Mackintosh, Schlicht, Liu, Larsen, Fogelholm, Raben and Martinez. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-10T23:38:26Z 2021-11-01 2021-11-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://hdl.handle.net/10362/129004 |
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eng |
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2296-861X PURE: 35038807 https://doi.org/10.3389/fnut.2021.733697 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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