2015/16 I-MOVE/I-MOVE+ multicentre case control study in Europe: moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage mismatched influenza B among children
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/5062 |
Resumo: | I-MOVE/I-MOVE+ study team - Portugal: Verónica Gomez, Ana Paula Rodrigues, Baltazar Nunes (Departamento de Epidemiologia, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisbon, Portugal); Pedro Pechirra, Paula Cristóvão, Patrícia Conde, Inês Costa (Departamento de Doenças Infeciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisbon, Portugal). |
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2015/16 I-MOVE/I-MOVE+ multicentre case control study in Europe: moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage mismatched influenza B among childrenCase Control StudyInfluenzainfluenza VaccineMulticentre StudyVaccine EffectivenessCuidados de SaúdeEfetividade da Vacina AntigripalVacina AntigripalI-MOVEI-MOVE+I-MOVE/I-MOVE+ study team - Portugal: Verónica Gomez, Ana Paula Rodrigues, Baltazar Nunes (Departamento de Epidemiologia, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisbon, Portugal); Pedro Pechirra, Paula Cristóvão, Patrícia Conde, Inês Costa (Departamento de Doenças Infeciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisbon, Portugal).Background:During the 2015/16 influenza season in Europe, the co-circulating influenza viruses were A(H1N1)pdm09 and B/Victoria, which was antigenically distinct from the B/Yamagata component in the trivalent influenza vaccine. Methods:We used the test negative design in a multicentre case–control study in twelve European countries to measure 2015/16 influenza vaccine effectiveness (VE) against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza. General practitioners swabbed a systematic sample of consulting ILI patients ainfluenza Vaccinend a random sample of influenza positive swabs were sequenced. We calculated adjusted VE against influenza A(H1N1)pdm09, A(H1N1)pdm09 genetic group 6B.1 and influenza B overall and by age group. Results: We included 11,430 ILI patients, of which 2272 were influenza A(H1N1)pdm09 and 2901 were influenza B cases. Overall VE against influenza A(H1N1)pdm09 was 32.9% (95% CI: 15.5-46.7). Among those aged 0–14, 15–64 and ≥65 years VE against A(H1N1)pdm09 was 31.9% (95% CI: -32.3-65.0), 41.4% (95%CI: 20.5-56.7) and 13.2% (95% CI: -38.0-45.3) respectively. Overall VE against influenza A(H1N1)pdm09 genetic group 6B.1 was 32.8% (95%CI: -4.1-56.7). Among those aged 0–14, 15–64 and ≥65 years VE against influenza B was -47.6% (95%CI: -124.9-3.1), 27.3% (95%CI: -4.6-49.4), and 9.3% (95%CI: -44.1-42.9) respectively. Conclusions: VE against influenza A(H1N1)pdm09 and its genetic group 6B.1 was moderate in children and adults, and low among individuals ≥65 years. VE against influenza B was low and heterogeneous among age groups. More information on effects of previous vaccination and previous infection are needed to understand the VE results against influenza B in the context of a mismatched vaccine.This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634446 to conduct the study in individuals aged 65 years or more. Framework contract No ECDC/2014/026Repositório Científico do Instituto Nacional de SaúdeKissling, EstherValenciano, MartaPozo, FranciscoVilcu, Ana-MariaReuss, AnnickaRizzo, CaterinaLarrauri, AmparoHorváth, Judit KrisztinaBrytting, MiaDomegan, LisaKorczyńska, MonikaMeijer, AdamMachado, AusendaIvanciuc, AlinaVišekruna Vučina, Vesnavan der Werf, SylvieSchweiger, BrunhildeBella, AntoninoGherasim, AlinFerenczi, AnnamáriaZakikhany, KatherinaO Donnell, JoanParadowska-Stankiewicz, IwonaDijkstra, FrederikaGuiomar, RaquelLazar, MihaelaKurečić Filipović, SanjaJohansen, KariMoren, AlainI-MOVE/I-MOVE+ study team2018-02-23T17:55:22Z2018-062018-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/5062engInfluenza Other Respir Viruses. 2018 Jul;12(4):423-437. doi: 10.1111/irv.12520. Epub 2017 Nov 101750-264010.1111/irv.12520info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:37Zoai:repositorio.insa.pt:10400.18/5062Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:46.495950Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
2015/16 I-MOVE/I-MOVE+ multicentre case control study in Europe: moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage mismatched influenza B among children |
| title |
2015/16 I-MOVE/I-MOVE+ multicentre case control study in Europe: moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage mismatched influenza B among children |
| spellingShingle |
2015/16 I-MOVE/I-MOVE+ multicentre case control study in Europe: moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage mismatched influenza B among children Kissling, Esther Case Control Study Influenza influenza Vaccine Multicentre Study Vaccine Effectiveness Cuidados de Saúde Efetividade da Vacina Antigripal Vacina Antigripal I-MOVE I-MOVE+ |
| title_short |
2015/16 I-MOVE/I-MOVE+ multicentre case control study in Europe: moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage mismatched influenza B among children |
| title_full |
2015/16 I-MOVE/I-MOVE+ multicentre case control study in Europe: moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage mismatched influenza B among children |
| title_fullStr |
2015/16 I-MOVE/I-MOVE+ multicentre case control study in Europe: moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage mismatched influenza B among children |
| title_full_unstemmed |
2015/16 I-MOVE/I-MOVE+ multicentre case control study in Europe: moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage mismatched influenza B among children |
| title_sort |
2015/16 I-MOVE/I-MOVE+ multicentre case control study in Europe: moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage mismatched influenza B among children |
| author |
Kissling, Esther |
| author_facet |
Kissling, Esther Valenciano, Marta Pozo, Francisco Vilcu, Ana-Maria Reuss, Annicka Rizzo, Caterina Larrauri, Amparo Horváth, Judit Krisztina Brytting, Mia Domegan, Lisa Korczyńska, Monika Meijer, Adam Machado, Ausenda Ivanciuc, Alina Višekruna Vučina, Vesna van der Werf, Sylvie Schweiger, Brunhilde Bella, Antonino Gherasim, Alin Ferenczi, Annamária Zakikhany, Katherina O Donnell, Joan Paradowska-Stankiewicz, Iwona Dijkstra, Frederika Guiomar, Raquel Lazar, Mihaela Kurečić Filipović, Sanja Johansen, Kari Moren, Alain I-MOVE/I-MOVE+ study team |
| author_role |
author |
| author2 |
Valenciano, Marta Pozo, Francisco Vilcu, Ana-Maria Reuss, Annicka Rizzo, Caterina Larrauri, Amparo Horváth, Judit Krisztina Brytting, Mia Domegan, Lisa Korczyńska, Monika Meijer, Adam Machado, Ausenda Ivanciuc, Alina Višekruna Vučina, Vesna van der Werf, Sylvie Schweiger, Brunhilde Bella, Antonino Gherasim, Alin Ferenczi, Annamária Zakikhany, Katherina O Donnell, Joan Paradowska-Stankiewicz, Iwona Dijkstra, Frederika Guiomar, Raquel Lazar, Mihaela Kurečić Filipović, Sanja Johansen, Kari Moren, Alain I-MOVE/I-MOVE+ study team |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Kissling, Esther Valenciano, Marta Pozo, Francisco Vilcu, Ana-Maria Reuss, Annicka Rizzo, Caterina Larrauri, Amparo Horváth, Judit Krisztina Brytting, Mia Domegan, Lisa Korczyńska, Monika Meijer, Adam Machado, Ausenda Ivanciuc, Alina Višekruna Vučina, Vesna van der Werf, Sylvie Schweiger, Brunhilde Bella, Antonino Gherasim, Alin Ferenczi, Annamária Zakikhany, Katherina O Donnell, Joan Paradowska-Stankiewicz, Iwona Dijkstra, Frederika Guiomar, Raquel Lazar, Mihaela Kurečić Filipović, Sanja Johansen, Kari Moren, Alain I-MOVE/I-MOVE+ study team |
| dc.subject.por.fl_str_mv |
Case Control Study Influenza influenza Vaccine Multicentre Study Vaccine Effectiveness Cuidados de Saúde Efetividade da Vacina Antigripal Vacina Antigripal I-MOVE I-MOVE+ |
| topic |
Case Control Study Influenza influenza Vaccine Multicentre Study Vaccine Effectiveness Cuidados de Saúde Efetividade da Vacina Antigripal Vacina Antigripal I-MOVE I-MOVE+ |
| description |
I-MOVE/I-MOVE+ study team - Portugal: Verónica Gomez, Ana Paula Rodrigues, Baltazar Nunes (Departamento de Epidemiologia, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisbon, Portugal); Pedro Pechirra, Paula Cristóvão, Patrícia Conde, Inês Costa (Departamento de Doenças Infeciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisbon, Portugal). |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018-02-23T17:55:22Z 2018-06 2018-06-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/5062 |
| url |
http://hdl.handle.net/10400.18/5062 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Influenza Other Respir Viruses. 2018 Jul;12(4):423-437. doi: 10.1111/irv.12520. Epub 2017 Nov 10 1750-2640 10.1111/irv.12520 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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