Vanadium(IV) complexes with methyl-substituted 8-hydroxyquinolines
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/135536 |
Resumo: | Nos. 19-03-00142 RFMEFI61917X0007 State Task 0082-2014-0007 (CITIS): AAAA-A17-117040610283-3 LA/P/0140/2020 |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Vanadium(IV) complexes with methyl-substituted 8-hydroxyquinolinesCatalytic potential in the oxidation of hydrocarbons and alcohols with peroxides and biological activity8-hydroxyquinolineBiological activityCatalytic propertiesCytotoxicity studiesVanadium(IV) complexesAnalytical ChemistryChemistry (miscellaneous)Molecular MedicinePharmaceutical ScienceDrug DiscoveryPhysical and Theoretical ChemistryOrganic ChemistrySDG 3 - Good Health and Well-beingNos. 19-03-00142 RFMEFI61917X0007 State Task 0082-2014-0007 (CITIS): AAAA-A17-117040610283-3 LA/P/0140/2020Methyl-substituted 8-hydroxyquinolines (Hquin) were successfully used to synthetize five-coordinated oxovanadium(IV) complexes: [VO(2,6-(Me)2-quin)2 ] (1), [VO(2,5-(Me)2-quin)2 ] (2) and [VO(2-Me-quin)2 ] (3). Complexes 1–3 demonstrated high catalytic activity in the oxidation of hydrocarbons with H2 O2 in acetonitrile at 50◦ C, in the presence of 2-pyrazinecarboxylic acid (PCA) as a cocatalyst. The maximum yield of cyclohexane oxidation products attained was 48%, which is high in the case of the oxidation of saturated hydrocarbons. The reaction leads to the formation of a mixture of cyclohexyl hydroperoxide, cyclohexanol and cyclohexanone. When triphenylphosphine is added, cyclohexyl hydroperoxide is completely converted to cyclohexanol. Consideration of the regioand bond-selectivity in the oxidation of n-heptane and methylcyclohexane, respectively, indicates that the oxidation proceeds with the participation of free hydroxyl radicals. The complexes show moderate activity in the oxidation of alcohols. Complexes 1 and 2 reduce the viability of colorectal (HCT116) and ovarian (A2780) carcinoma cell lines and of normal dermal fibroblasts without showing a specific selectivity for cancer cell lines. Complex 3 on the other hand, shows a higher cytotoxicity in a colorectal carcinoma cell line (HCT116), a lower cytotoxicity towards normal dermal fibroblasts and no effect in an ovarian carcinoma cell line (order of magnitude HCT116 > fibroblasts > A2780).DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitRUNPalion-Gazda, JoannaLuz, AndréRaposo, Luis R.Choroba, KatarzynaNycz, Jacek E.Bieńko, AlinaLewińska, AgnieszkaErfurt, KarolBaptista, Pedro V.Machura, BarbaraFernandes, Alexandra R.Shul’pina, Lidia S.Ikonnikov, Nikolay S.Shul’pin, Georgiy B.2022-03-30T11:55:29Z2021-10-212021-10-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article23application/pdfhttp://hdl.handle.net/10362/135536eng1420-3049PURE: 42510251https://doi.org/10.3390/molecules26216364info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:13:51Zoai:run.unl.pt:10362/135536Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:26.223857Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Vanadium(IV) complexes with methyl-substituted 8-hydroxyquinolines Catalytic potential in the oxidation of hydrocarbons and alcohols with peroxides and biological activity |
| title |
Vanadium(IV) complexes with methyl-substituted 8-hydroxyquinolines |
| spellingShingle |
Vanadium(IV) complexes with methyl-substituted 8-hydroxyquinolines Palion-Gazda, Joanna 8-hydroxyquinoline Biological activity Catalytic properties Cytotoxicity studies Vanadium(IV) complexes Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry SDG 3 - Good Health and Well-being |
| title_short |
Vanadium(IV) complexes with methyl-substituted 8-hydroxyquinolines |
| title_full |
Vanadium(IV) complexes with methyl-substituted 8-hydroxyquinolines |
| title_fullStr |
Vanadium(IV) complexes with methyl-substituted 8-hydroxyquinolines |
| title_full_unstemmed |
Vanadium(IV) complexes with methyl-substituted 8-hydroxyquinolines |
| title_sort |
Vanadium(IV) complexes with methyl-substituted 8-hydroxyquinolines |
| author |
Palion-Gazda, Joanna |
| author_facet |
Palion-Gazda, Joanna Luz, André Raposo, Luis R. Choroba, Katarzyna Nycz, Jacek E. Bieńko, Alina Lewińska, Agnieszka Erfurt, Karol Baptista, Pedro V. Machura, Barbara Fernandes, Alexandra R. Shul’pina, Lidia S. Ikonnikov, Nikolay S. Shul’pin, Georgiy B. |
| author_role |
author |
| author2 |
Luz, André Raposo, Luis R. Choroba, Katarzyna Nycz, Jacek E. Bieńko, Alina Lewińska, Agnieszka Erfurt, Karol Baptista, Pedro V. Machura, Barbara Fernandes, Alexandra R. Shul’pina, Lidia S. Ikonnikov, Nikolay S. Shul’pin, Georgiy B. |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
DCV - Departamento de Ciências da Vida UCIBIO - Applied Molecular Biosciences Unit RUN |
| dc.contributor.author.fl_str_mv |
Palion-Gazda, Joanna Luz, André Raposo, Luis R. Choroba, Katarzyna Nycz, Jacek E. Bieńko, Alina Lewińska, Agnieszka Erfurt, Karol Baptista, Pedro V. Machura, Barbara Fernandes, Alexandra R. Shul’pina, Lidia S. Ikonnikov, Nikolay S. Shul’pin, Georgiy B. |
| dc.subject.por.fl_str_mv |
8-hydroxyquinoline Biological activity Catalytic properties Cytotoxicity studies Vanadium(IV) complexes Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry SDG 3 - Good Health and Well-being |
| topic |
8-hydroxyquinoline Biological activity Catalytic properties Cytotoxicity studies Vanadium(IV) complexes Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry SDG 3 - Good Health and Well-being |
| description |
Nos. 19-03-00142 RFMEFI61917X0007 State Task 0082-2014-0007 (CITIS): AAAA-A17-117040610283-3 LA/P/0140/2020 |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-10-21 2021-10-21T00:00:00Z 2022-03-30T11:55:29Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/135536 |
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http://hdl.handle.net/10362/135536 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1420-3049 PURE: 42510251 https://doi.org/10.3390/molecules26216364 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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23 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138085519228928 |