Understanding the effect of iron on the candicidal activity of echinocandins

Detalhes bibliográficos
Autor(a) principal: Luís, Cláudia
Data de Publicação: 2021
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/142188
Resumo: "Fungal infections range from superficial skin rashes to health-threatening invasive infections. Invasive candidiasis, caused by the opportunistic yeast Candida spp., is the most common fungal infection among hospitalized patients, being associated with high morbidity and mortality rates. For the treatment of this disease echinocandins are generally the preferred antifungal option because they are fungicidal and potent inhibitors of the fungal enzyme β-1,3-glucan synthetase. Iron overload promotes microbial growth and therefore it is considered a risk factor for many infections. Preliminary results from our laboratory suggest that iron overload may as well affect the efficacy of echinocandins against Candida albicans, putting forward the idea that the availability of iron in the host may interfere with the treatment of serious infections caused by Candida albicans. (...)"
id RCAP_5d70dcc9584e2ebdb66b5ef0ff11a8b8
oai_identifier_str oai:run.unl.pt:10362/142188
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Understanding the effect of iron on the candicidal activity of echinocandinsResearch Subject Categories::INTERDISCIPLINARY RESEARCH AREASResearch Subject Categories::INTERDISCIPLINARY RESEARCH AREAS"Fungal infections range from superficial skin rashes to health-threatening invasive infections. Invasive candidiasis, caused by the opportunistic yeast Candida spp., is the most common fungal infection among hospitalized patients, being associated with high morbidity and mortality rates. For the treatment of this disease echinocandins are generally the preferred antifungal option because they are fungicidal and potent inhibitors of the fungal enzyme β-1,3-glucan synthetase. Iron overload promotes microbial growth and therefore it is considered a risk factor for many infections. Preliminary results from our laboratory suggest that iron overload may as well affect the efficacy of echinocandins against Candida albicans, putting forward the idea that the availability of iron in the host may interfere with the treatment of serious infections caused by Candida albicans. (...)"Instituto de Tecnologia Química e Biológica António Xavier. Universidade Nova de LisboaRUNLuís, Cláudia2021-10-252024-10-31T00:00:00Z2021-10-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/142188enginfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:19:40Zoai:run.unl.pt:10362/142188Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:50:11.671741Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Understanding the effect of iron on the candicidal activity of echinocandins
title Understanding the effect of iron on the candicidal activity of echinocandins
spellingShingle Understanding the effect of iron on the candicidal activity of echinocandins
Luís, Cláudia
Research Subject Categories::INTERDISCIPLINARY RESEARCH AREAS
Research Subject Categories::INTERDISCIPLINARY RESEARCH AREAS
title_short Understanding the effect of iron on the candicidal activity of echinocandins
title_full Understanding the effect of iron on the candicidal activity of echinocandins
title_fullStr Understanding the effect of iron on the candicidal activity of echinocandins
title_full_unstemmed Understanding the effect of iron on the candicidal activity of echinocandins
title_sort Understanding the effect of iron on the candicidal activity of echinocandins
author Luís, Cláudia
author_facet Luís, Cláudia
author_role author
dc.contributor.none.fl_str_mv RUN
dc.contributor.author.fl_str_mv Luís, Cláudia
dc.subject.por.fl_str_mv Research Subject Categories::INTERDISCIPLINARY RESEARCH AREAS
Research Subject Categories::INTERDISCIPLINARY RESEARCH AREAS
topic Research Subject Categories::INTERDISCIPLINARY RESEARCH AREAS
Research Subject Categories::INTERDISCIPLINARY RESEARCH AREAS
description "Fungal infections range from superficial skin rashes to health-threatening invasive infections. Invasive candidiasis, caused by the opportunistic yeast Candida spp., is the most common fungal infection among hospitalized patients, being associated with high morbidity and mortality rates. For the treatment of this disease echinocandins are generally the preferred antifungal option because they are fungicidal and potent inhibitors of the fungal enzyme β-1,3-glucan synthetase. Iron overload promotes microbial growth and therefore it is considered a risk factor for many infections. Preliminary results from our laboratory suggest that iron overload may as well affect the efficacy of echinocandins against Candida albicans, putting forward the idea that the availability of iron in the host may interfere with the treatment of serious infections caused by Candida albicans. (...)"
publishDate 2021
dc.date.none.fl_str_mv 2021-10-25
2021-10-25T00:00:00Z
2024-10-31T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/142188
url http://hdl.handle.net/10362/142188
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto de Tecnologia Química e Biológica António Xavier. Universidade Nova de Lisboa
publisher.none.fl_str_mv Instituto de Tecnologia Química e Biológica António Xavier. Universidade Nova de Lisboa
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799138099271303168

Registros relacionados