MOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue homeostasis

Detalhes bibliográficos
Autor(a) principal: Delgado, Inês L. S.
Data de Publicação: 2020
Outros Autores: Carmona, Bruno, Nolasco, Sofia, Santos, Dulce, Leitão, Alexandre, Soares, Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/12415
Resumo: UID/QUI/00100/2019. Project IPL/2019/MOONOFCILI/ESTeSL
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spelling MOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue homeostasisMOBCell polarityCytokinesisTissue homeostasisProliferationMorphogenesisHippoMENUID/QUI/00100/2019Project IPL/2019/MOONOFCILI/ESTeSLUID/QUI/00100/2019. Project IPL/2019/MOONOFCILI/ESTeSLThe MOB family proteins are constituted by highly conserved eukaryote kinase signal adaptors that are often essential both for cell and organism survival. Historically, MOB family proteins have been described as kinase activators participating in Hippo and Mitotic Exit Network/ Septation Initiation Network (MEN/SIN) signaling pathways that have central roles in regulating cytokinesis, cell polarity, cell proliferation, and cell fate to control organ growth and regeneration. In metazoans, MOB proteins act as central signal adaptors of the core kinase module MST1/2, LATS1/2, and NDR1/2 kinases that phosphorylate the YAP/TAZ transcriptional co-activators, effectors of the Hippo signaling pathway. More recently, MOBs have been shown to also have non-kinase partners and to be involved in cilia biology, indicating that its activity and regulation is more diverse than expected. In this review, we explore the possible ancestral role of MEN/SIN pathways on the built-in nature of a more complex and functionally expanded Hippo pathway, by focusing on the most conserved components of these pathways, the MOB proteins. We discuss the current knowledge of MOBs-regulated signaling, with emphasis on its evolutionary history and role in morphogenesis, cytokinesis, and cell polarity from unicellular to multicellular organisms.MDPIRCIPLDelgado, Inês L. S.Carmona, BrunoNolasco, SofiaSantos, DulceLeitão, AlexandreSoares, Helena2020-12-06T18:23:14Z2020-112020-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/12415engDelgado IL, Carmona B, Nolasco S, Santos D, Leitão A, Soares H. MOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue homeostasis. Biology (Basel). 2020;9(12):E413.10.3390/biology9120413info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:05:17Zoai:repositorio.ipl.pt:10400.21/12415Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:20:30.483718Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv MOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue homeostasis
title MOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue homeostasis
spellingShingle MOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue homeostasis
Delgado, Inês L. S.
MOB
Cell polarity
Cytokinesis
Tissue homeostasis
Proliferation
Morphogenesis
Hippo
MEN
UID/QUI/00100/2019
Project IPL/2019/MOONOFCILI/ESTeSL
title_short MOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue homeostasis
title_full MOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue homeostasis
title_fullStr MOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue homeostasis
title_full_unstemmed MOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue homeostasis
title_sort MOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue homeostasis
author Delgado, Inês L. S.
author_facet Delgado, Inês L. S.
Carmona, Bruno
Nolasco, Sofia
Santos, Dulce
Leitão, Alexandre
Soares, Helena
author_role author
author2 Carmona, Bruno
Nolasco, Sofia
Santos, Dulce
Leitão, Alexandre
Soares, Helena
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Delgado, Inês L. S.
Carmona, Bruno
Nolasco, Sofia
Santos, Dulce
Leitão, Alexandre
Soares, Helena
dc.subject.por.fl_str_mv MOB
Cell polarity
Cytokinesis
Tissue homeostasis
Proliferation
Morphogenesis
Hippo
MEN
UID/QUI/00100/2019
Project IPL/2019/MOONOFCILI/ESTeSL
topic MOB
Cell polarity
Cytokinesis
Tissue homeostasis
Proliferation
Morphogenesis
Hippo
MEN
UID/QUI/00100/2019
Project IPL/2019/MOONOFCILI/ESTeSL
description UID/QUI/00100/2019. Project IPL/2019/MOONOFCILI/ESTeSL
publishDate 2020
dc.date.none.fl_str_mv 2020-12-06T18:23:14Z
2020-11
2020-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/12415
url http://hdl.handle.net/10400.21/12415
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Delgado IL, Carmona B, Nolasco S, Santos D, Leitão A, Soares H. MOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue homeostasis. Biology (Basel). 2020;9(12):E413.
10.3390/biology9120413
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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