Common variable immunodeficiency-associated inflammatory enteropathy: the new era of biological therapy
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/58275 |
Resumo: | Common variable immunodeficiency (CVID) is the most frequent form of immunodeficiency in adults. Clinical manifestations are heterogeneous with an increased susceptibility to infections and inflammatory conditions, namely autoimmune diseases, such as inflammatory bowel disease. We present the clinical case of a Caucasian female patient, 21 years old, with a past medical history of CVID, with multiple visits to the emergency department due to abdominal pain in the lower quadrants and diarrhea. Her biochemical analysis showed elevated inflammatory parameters. Stool cultures and parasitological examination of feces were negative. Ileocolonoscopy revealed lymphoid nodular hyperplasia of the terminal ileum, and the small bowel capsule endoscopy demonstrated edema and multiple pleomorphic ulcers (Lewis score = 1,104). CVID-associated inflammatory enteropathy was suspected. Budesonide 9 mg/day was started, but no positive clinical response was observed. It was decided to initiate biological therapy with infliximab. The patient's condition is currently clinically improved with no complications due to biological therapy. |
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Common variable immunodeficiency-associated inflammatory enteropathy: the new era of biological therapyBiological therapyCommon variable immunodeficiencyCrohn diseaseInflammatory bowel diseaseInfliximabSmall bowel capsule endoscopyScience & TechnologyCommon variable immunodeficiency (CVID) is the most frequent form of immunodeficiency in adults. Clinical manifestations are heterogeneous with an increased susceptibility to infections and inflammatory conditions, namely autoimmune diseases, such as inflammatory bowel disease. We present the clinical case of a Caucasian female patient, 21 years old, with a past medical history of CVID, with multiple visits to the emergency department due to abdominal pain in the lower quadrants and diarrhea. Her biochemical analysis showed elevated inflammatory parameters. Stool cultures and parasitological examination of feces were negative. Ileocolonoscopy revealed lymphoid nodular hyperplasia of the terminal ileum, and the small bowel capsule endoscopy demonstrated edema and multiple pleomorphic ulcers (Lewis score = 1,104). CVID-associated inflammatory enteropathy was suspected. Budesonide 9 mg/day was started, but no positive clinical response was observed. It was decided to initiate biological therapy with infliximab. The patient's condition is currently clinically improved with no complications due to biological therapy.(undefined)Karger PublishersUniversidade do MinhoArieira, CátiaCastro, Francisca Dias deMoreira, Maria JoãoCotter, José Almeida Berkeley2018-112018-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58275eng2341-454510.1159/000486448info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:28:18Zoai:repositorium.sdum.uminho.pt:1822/58275Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:23:04.362497Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Common variable immunodeficiency-associated inflammatory enteropathy: the new era of biological therapy |
title |
Common variable immunodeficiency-associated inflammatory enteropathy: the new era of biological therapy |
spellingShingle |
Common variable immunodeficiency-associated inflammatory enteropathy: the new era of biological therapy Arieira, Cátia Biological therapy Common variable immunodeficiency Crohn disease Inflammatory bowel disease Infliximab Small bowel capsule endoscopy Science & Technology |
title_short |
Common variable immunodeficiency-associated inflammatory enteropathy: the new era of biological therapy |
title_full |
Common variable immunodeficiency-associated inflammatory enteropathy: the new era of biological therapy |
title_fullStr |
Common variable immunodeficiency-associated inflammatory enteropathy: the new era of biological therapy |
title_full_unstemmed |
Common variable immunodeficiency-associated inflammatory enteropathy: the new era of biological therapy |
title_sort |
Common variable immunodeficiency-associated inflammatory enteropathy: the new era of biological therapy |
author |
Arieira, Cátia |
author_facet |
Arieira, Cátia Castro, Francisca Dias de Moreira, Maria João Cotter, José Almeida Berkeley |
author_role |
author |
author2 |
Castro, Francisca Dias de Moreira, Maria João Cotter, José Almeida Berkeley |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Arieira, Cátia Castro, Francisca Dias de Moreira, Maria João Cotter, José Almeida Berkeley |
dc.subject.por.fl_str_mv |
Biological therapy Common variable immunodeficiency Crohn disease Inflammatory bowel disease Infliximab Small bowel capsule endoscopy Science & Technology |
topic |
Biological therapy Common variable immunodeficiency Crohn disease Inflammatory bowel disease Infliximab Small bowel capsule endoscopy Science & Technology |
description |
Common variable immunodeficiency (CVID) is the most frequent form of immunodeficiency in adults. Clinical manifestations are heterogeneous with an increased susceptibility to infections and inflammatory conditions, namely autoimmune diseases, such as inflammatory bowel disease. We present the clinical case of a Caucasian female patient, 21 years old, with a past medical history of CVID, with multiple visits to the emergency department due to abdominal pain in the lower quadrants and diarrhea. Her biochemical analysis showed elevated inflammatory parameters. Stool cultures and parasitological examination of feces were negative. Ileocolonoscopy revealed lymphoid nodular hyperplasia of the terminal ileum, and the small bowel capsule endoscopy demonstrated edema and multiple pleomorphic ulcers (Lewis score = 1,104). CVID-associated inflammatory enteropathy was suspected. Budesonide 9 mg/day was started, but no positive clinical response was observed. It was decided to initiate biological therapy with infliximab. The patient's condition is currently clinically improved with no complications due to biological therapy. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11 2018-11-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/58275 |
url |
http://hdl.handle.net/1822/58275 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2341-4545 10.1159/000486448 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Karger Publishers |
publisher.none.fl_str_mv |
Karger Publishers |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132704463126528 |