Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat

Detalhes bibliográficos
Autor(a) principal: Ansah, Osei B.
Data de Publicação: 2010
Outros Autores: Bourbia, Nora, Gonçalves, Leonor, Almeida, Armando, Pertovaara, Antti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/29554
Resumo: The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR(1) and mGluR(5), and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.
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spelling Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic ratAmygdalAversive place-conditioningDescending pain modulationEmotional painMechanical pain sensibilityPeripheral neuropathyAmygdalaScience & TechnologyThe role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR(1) and mGluR(5), and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.This study was supported by the Academy of Finland, Helsinki, Finland, the Sigrid Juselius Foundation, Helsinki, Finland, the Center for International Mobility (CIMO), Helsinki, Finland, the Portuguese Foundation for Science and Technology, Lisbon, Portugal, and the Gulbenkian Foundation, Lisbon, Portugal.ElsevierUniversidade do MinhoAnsah, Osei B.Bourbia, NoraGonçalves, LeonorAlmeida, ArmandoPertovaara, Antti20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/29554eng0166-432810.1016/j.bbr.2010.01.02120097232http://www.sciencedirect.com/science/article/pii/S0166432810000458info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:55:34Zoai:repositorium.sdum.uminho.pt:1822/29554Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:45:06.475946Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat
title Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat
spellingShingle Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat
Ansah, Osei B.
Amygdal
Aversive place-conditioning
Descending pain modulation
Emotional pain
Mechanical pain sensibility
Peripheral neuropathy
Amygdala
Science & Technology
title_short Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat
title_full Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat
title_fullStr Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat
title_full_unstemmed Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat
title_sort Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat
author Ansah, Osei B.
author_facet Ansah, Osei B.
Bourbia, Nora
Gonçalves, Leonor
Almeida, Armando
Pertovaara, Antti
author_role author
author2 Bourbia, Nora
Gonçalves, Leonor
Almeida, Armando
Pertovaara, Antti
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Ansah, Osei B.
Bourbia, Nora
Gonçalves, Leonor
Almeida, Armando
Pertovaara, Antti
dc.subject.por.fl_str_mv Amygdal
Aversive place-conditioning
Descending pain modulation
Emotional pain
Mechanical pain sensibility
Peripheral neuropathy
Amygdala
Science & Technology
topic Amygdal
Aversive place-conditioning
Descending pain modulation
Emotional pain
Mechanical pain sensibility
Peripheral neuropathy
Amygdala
Science & Technology
description The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR(1) and mGluR(5), and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/29554
url http://hdl.handle.net/1822/29554
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0166-4328
10.1016/j.bbr.2010.01.021
20097232
http://www.sciencedirect.com/science/article/pii/S0166432810000458
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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