The Burden of Post-Thrombotic Syndrome in a Long-Term Retrospective Cohort in Northern Portugal
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567 |
Resumo: | Introduction: Post-thrombotic syndrome is a frequent and disabling complication of deep venous thrombosis. Its incidence is not described in the Portuguese population. The objective of this study is to report the incidence and severity of post-thrombotic syndrome after the initial episode of deep venous thrombosis.Material and Methods: This is an observational, unicentric, retrospective cohort of patients who had a first episode of deep venous thrombosis in the lower limb, documented with duplex ultrasound (n = 101). The modified Villalta score was applied by phone interview for the diagnosis and staging of post-thrombotic syndrome. The quality of life of patients was measured with the modified CIVIQ 14 classification.Results: Median follow-up time was six years (interquartile range 1). Severe post-thrombotic syndrome was present in 27% of patients and moderate in 33%. Performing physical activity at the time of the interview was associated with lower incidence of post-thrombotic syndrome (relative risk 0.489; 95% confidence interval = 0.320 - 0.748). Body weight gain after deep venous thrombosis (relative risk 2.188; 95% confidence interval 1.137 - 4.210) and lower education levels (relative risk 2.005; 95% confidence interval 1.297 - 3.098) were associated positively with post-thrombotic syndrome. Quality of life was 90 ± 17 vs 64 ± 18 vs 43 ± 15 in patients without postthrombotic syndrome, with moderate post-thrombotic syndrome and with severe post-thrombotic syndrome, respectively (p < 0.001).Discussion: The long-term incidence of post-thrombotic syndrome in a cohort of patients from Northern Portugal is higher than in other studies and correlates with worse adjusted CIVIQ-14 scores.Conclusion: Large studies of prospective nature could provide more definitive evidence. |
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The Burden of Post-Thrombotic Syndrome in a Long-Term Retrospective Cohort in Northern PortugalO Impacto a Longo Prazo da Síndrome Pós-Trombótica Numa Coorte Retrospetiva no Norte de PortugalPostthrombotic SyndromeQuality of LifeVenous InsufficiencyInsuficiência VenosaQualidade de VidaSíndrome Pós-TrombóticaIntroduction: Post-thrombotic syndrome is a frequent and disabling complication of deep venous thrombosis. Its incidence is not described in the Portuguese population. The objective of this study is to report the incidence and severity of post-thrombotic syndrome after the initial episode of deep venous thrombosis.Material and Methods: This is an observational, unicentric, retrospective cohort of patients who had a first episode of deep venous thrombosis in the lower limb, documented with duplex ultrasound (n = 101). The modified Villalta score was applied by phone interview for the diagnosis and staging of post-thrombotic syndrome. The quality of life of patients was measured with the modified CIVIQ 14 classification.Results: Median follow-up time was six years (interquartile range 1). Severe post-thrombotic syndrome was present in 27% of patients and moderate in 33%. Performing physical activity at the time of the interview was associated with lower incidence of post-thrombotic syndrome (relative risk 0.489; 95% confidence interval = 0.320 - 0.748). Body weight gain after deep venous thrombosis (relative risk 2.188; 95% confidence interval 1.137 - 4.210) and lower education levels (relative risk 2.005; 95% confidence interval 1.297 - 3.098) were associated positively with post-thrombotic syndrome. Quality of life was 90 ± 17 vs 64 ± 18 vs 43 ± 15 in patients without postthrombotic syndrome, with moderate post-thrombotic syndrome and with severe post-thrombotic syndrome, respectively (p < 0.001).Discussion: The long-term incidence of post-thrombotic syndrome in a cohort of patients from Northern Portugal is higher than in other studies and correlates with worse adjusted CIVIQ-14 scores.Conclusion: Large studies of prospective nature could provide more definitive evidence.Introdução: A síndrome pós-trombótica é uma complicação frequente da trombose venosa profunda, contudo a incidência em Portugal é desconhecida. O principal objetivo é determinar a incidência e gravidade da síndrome pós-trombótica após primeiro episódio de trombose venosa profunda.Material e Métodos: Estudo de coorte observacional, unicêntrico e retrospetivo de doentes com primeiro episódio de trombose venosa profunda do membro inferior documentado por eco-doppler (n = 101). O score Villalta modificado foi aplicado por entrevista telefónica para diagnóstico e categorização da síndrome pós-trombótica. A qualidade de vida dos pacientes foi avaliada pela classificação CIVIQ -14 ajustada.Resultados: A mediana do tempo de seguimento foi de seis anos. A síndrome pós-trombótica grave esteve presente em 27% emoderada em 33%. A prática de atividade física no momento da entrevista esteve associada a uma menor incidência de síndromepós-trombótica (risco relativo = 0,489; intervalo de confiança de 95% = 0,320 - 0,748). O aumento de peso após trombose venosa profunda (risco relativo = 2,188; intervalo de confiança de 95% = 1,137 - 4,210) e menores habilitações literárias (risco relativo = 2,005; intervalo de confiança de 95% = 1,297 - 3,098) revelaram associação positiva com síndrome pós-trombótica. A qualidade de vida correlacionou-se com a síndrome pós-trombótica, sendo 90 ± 17, 64 ± 18 e 43 ± 15 em doentes sem síndrome pós-trombótica, com síndrome pós-trombótica moderada e com síndrome pós-trombótica severa, respetivamente (p < 0,001).Discussão: Nesta coorte de doentes no Norte de Portugal, a incidência a longo prazo da síndrome pós-trombótica é superior a outros estudos e correlaciona-se com piores resultados na classificação CIVIQ-14 ajustada.Conclusão: Estudos prospetivos são necessários para maior evidência.Ordem dos Médicos2021-01-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfimage/pngimage/pngimage/pngimage/pngimage/pngimage/pngapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfapplication/pdfapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567oai:ojs.www.actamedicaportuguesa.com:article/13567Acta Médica Portuguesa; Vol. 34 No. 1 (2021): January; 35-43Acta Médica Portuguesa; Vol. 34 N.º 1 (2021): Janeiro; 35-431646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/6118https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/6119https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/6120https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/6121https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/6122https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/6123https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12301https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12302https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12303https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12304https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12305https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12306https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12307https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12308https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12309https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12310https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12311https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12312https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12313https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12404https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12425https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12440Direitos de Autor (c) 2020 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessMendes-Andrade, InêsDias-Neto, MarinaRocha-Neves, JoãoMansilha, Armando2022-12-20T11:06:55Zoai:ojs.www.actamedicaportuguesa.com:article/13567Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:20:22.226692Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Burden of Post-Thrombotic Syndrome in a Long-Term Retrospective Cohort in Northern Portugal O Impacto a Longo Prazo da Síndrome Pós-Trombótica Numa Coorte Retrospetiva no Norte de Portugal |
title |
The Burden of Post-Thrombotic Syndrome in a Long-Term Retrospective Cohort in Northern Portugal |
spellingShingle |
The Burden of Post-Thrombotic Syndrome in a Long-Term Retrospective Cohort in Northern Portugal Mendes-Andrade, Inês Postthrombotic Syndrome Quality of Life Venous Insufficiency Insuficiência Venosa Qualidade de Vida Síndrome Pós-Trombótica |
title_short |
The Burden of Post-Thrombotic Syndrome in a Long-Term Retrospective Cohort in Northern Portugal |
title_full |
The Burden of Post-Thrombotic Syndrome in a Long-Term Retrospective Cohort in Northern Portugal |
title_fullStr |
The Burden of Post-Thrombotic Syndrome in a Long-Term Retrospective Cohort in Northern Portugal |
title_full_unstemmed |
The Burden of Post-Thrombotic Syndrome in a Long-Term Retrospective Cohort in Northern Portugal |
title_sort |
The Burden of Post-Thrombotic Syndrome in a Long-Term Retrospective Cohort in Northern Portugal |
author |
Mendes-Andrade, Inês |
author_facet |
Mendes-Andrade, Inês Dias-Neto, Marina Rocha-Neves, João Mansilha, Armando |
author_role |
author |
author2 |
Dias-Neto, Marina Rocha-Neves, João Mansilha, Armando |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Mendes-Andrade, Inês Dias-Neto, Marina Rocha-Neves, João Mansilha, Armando |
dc.subject.por.fl_str_mv |
Postthrombotic Syndrome Quality of Life Venous Insufficiency Insuficiência Venosa Qualidade de Vida Síndrome Pós-Trombótica |
topic |
Postthrombotic Syndrome Quality of Life Venous Insufficiency Insuficiência Venosa Qualidade de Vida Síndrome Pós-Trombótica |
description |
Introduction: Post-thrombotic syndrome is a frequent and disabling complication of deep venous thrombosis. Its incidence is not described in the Portuguese population. The objective of this study is to report the incidence and severity of post-thrombotic syndrome after the initial episode of deep venous thrombosis.Material and Methods: This is an observational, unicentric, retrospective cohort of patients who had a first episode of deep venous thrombosis in the lower limb, documented with duplex ultrasound (n = 101). The modified Villalta score was applied by phone interview for the diagnosis and staging of post-thrombotic syndrome. The quality of life of patients was measured with the modified CIVIQ 14 classification.Results: Median follow-up time was six years (interquartile range 1). Severe post-thrombotic syndrome was present in 27% of patients and moderate in 33%. Performing physical activity at the time of the interview was associated with lower incidence of post-thrombotic syndrome (relative risk 0.489; 95% confidence interval = 0.320 - 0.748). Body weight gain after deep venous thrombosis (relative risk 2.188; 95% confidence interval 1.137 - 4.210) and lower education levels (relative risk 2.005; 95% confidence interval 1.297 - 3.098) were associated positively with post-thrombotic syndrome. Quality of life was 90 ± 17 vs 64 ± 18 vs 43 ± 15 in patients without postthrombotic syndrome, with moderate post-thrombotic syndrome and with severe post-thrombotic syndrome, respectively (p < 0.001).Discussion: The long-term incidence of post-thrombotic syndrome in a cohort of patients from Northern Portugal is higher than in other studies and correlates with worse adjusted CIVIQ-14 scores.Conclusion: Large studies of prospective nature could provide more definitive evidence. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-04 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567 oai:ojs.www.actamedicaportuguesa.com:article/13567 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567 |
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eng |
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eng |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/6118 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/6119 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/6120 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/6121 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/6122 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/6123 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12301 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12302 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12303 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12304 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12305 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12306 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12307 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12308 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12309 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12310 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12311 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12312 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12313 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12404 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12425 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13567/12440 |
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Direitos de Autor (c) 2020 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
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Direitos de Autor (c) 2020 Acta Médica Portuguesa |
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Ordem dos Médicos |
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Ordem dos Médicos |
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Acta Médica Portuguesa; Vol. 34 No. 1 (2021): January; 35-43 Acta Médica Portuguesa; Vol. 34 N.º 1 (2021): Janeiro; 35-43 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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