Combined toxicity of graphite-diamond nanoparticles and thiabendazole to Daphnia magna
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/36939 |
Resumo: | Carbon-based nanomaterials exhibit unique properties that make them suitable for a wide variety of industrial and biomedical applications. In this work, we studied the acute toxicity of graphite-diamond nanoparticles (GDN) combined with the fungicide thiabendazole (TBZ) to the immobilization of the cladoceran Daphnia magna in the presence and absence of the micro green algae Raphidocelis subcapitata, supplied as food source. The toxicity of GDN to D. magna decreased in the presence of R. subcapitata, while that of TBZ increased, the latter suggesting a carrier effect to TBZ. GDN-TBZ mixtures were fitted to the most common conceptual models applied to mixture toxicity: Concentration Addition (CA), Independent Action (IA) and Combination Index (CI). For GDN-TBZ mixtures in the absence of food the best fit was obtained with dose ratio deviation from CA model, while in the presence of food, dose level deviation from CA gave a better fit. The binary mixtures of GDN and TBZ showed synergistic toxic interactions at low concentrations, which could be attributed to the increased bioavailability of TBZ adsorbed on GDN. For higher concentrations of GDN, the binary mixtures turned antagonistic due to particle agglomeration. Our study provides evidence that deviations from additivity are dose dependent and relevant for the risk assessment of mixtures of nanoparticles with other chemical pollutants. |
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Combined toxicity of graphite-diamond nanoparticles and thiabendazole to Daphnia magnaGraphite-diamond nanoparticlesThiabendazoleMixture toxicityDaphnia magnaSynergismBioavailabilityCarbon-based nanomaterials exhibit unique properties that make them suitable for a wide variety of industrial and biomedical applications. In this work, we studied the acute toxicity of graphite-diamond nanoparticles (GDN) combined with the fungicide thiabendazole (TBZ) to the immobilization of the cladoceran Daphnia magna in the presence and absence of the micro green algae Raphidocelis subcapitata, supplied as food source. The toxicity of GDN to D. magna decreased in the presence of R. subcapitata, while that of TBZ increased, the latter suggesting a carrier effect to TBZ. GDN-TBZ mixtures were fitted to the most common conceptual models applied to mixture toxicity: Concentration Addition (CA), Independent Action (IA) and Combination Index (CI). For GDN-TBZ mixtures in the absence of food the best fit was obtained with dose ratio deviation from CA model, while in the presence of food, dose level deviation from CA gave a better fit. The binary mixtures of GDN and TBZ showed synergistic toxic interactions at low concentrations, which could be attributed to the increased bioavailability of TBZ adsorbed on GDN. For higher concentrations of GDN, the binary mixtures turned antagonistic due to particle agglomeration. Our study provides evidence that deviations from additivity are dose dependent and relevant for the risk assessment of mixtures of nanoparticles with other chemical pollutants.Elsevier2023-04-11T15:39:39Z2019-10-20T00:00:00Z2019-10-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/36939eng0048-969710.1016/j.scitotenv.2019.06.316Martín-de-Lucía, IdoiaGonçalves, Sandra F.Leganés, FranciscoFernández-Piñas, FranciscaRosal, RobertoLoureiro, Susanainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:11:15Zoai:ria.ua.pt:10773/36939Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:07:36.422445Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Combined toxicity of graphite-diamond nanoparticles and thiabendazole to Daphnia magna |
title |
Combined toxicity of graphite-diamond nanoparticles and thiabendazole to Daphnia magna |
spellingShingle |
Combined toxicity of graphite-diamond nanoparticles and thiabendazole to Daphnia magna Martín-de-Lucía, Idoia Graphite-diamond nanoparticles Thiabendazole Mixture toxicity Daphnia magna Synergism Bioavailability |
title_short |
Combined toxicity of graphite-diamond nanoparticles and thiabendazole to Daphnia magna |
title_full |
Combined toxicity of graphite-diamond nanoparticles and thiabendazole to Daphnia magna |
title_fullStr |
Combined toxicity of graphite-diamond nanoparticles and thiabendazole to Daphnia magna |
title_full_unstemmed |
Combined toxicity of graphite-diamond nanoparticles and thiabendazole to Daphnia magna |
title_sort |
Combined toxicity of graphite-diamond nanoparticles and thiabendazole to Daphnia magna |
author |
Martín-de-Lucía, Idoia |
author_facet |
Martín-de-Lucía, Idoia Gonçalves, Sandra F. Leganés, Francisco Fernández-Piñas, Francisca Rosal, Roberto Loureiro, Susana |
author_role |
author |
author2 |
Gonçalves, Sandra F. Leganés, Francisco Fernández-Piñas, Francisca Rosal, Roberto Loureiro, Susana |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Martín-de-Lucía, Idoia Gonçalves, Sandra F. Leganés, Francisco Fernández-Piñas, Francisca Rosal, Roberto Loureiro, Susana |
dc.subject.por.fl_str_mv |
Graphite-diamond nanoparticles Thiabendazole Mixture toxicity Daphnia magna Synergism Bioavailability |
topic |
Graphite-diamond nanoparticles Thiabendazole Mixture toxicity Daphnia magna Synergism Bioavailability |
description |
Carbon-based nanomaterials exhibit unique properties that make them suitable for a wide variety of industrial and biomedical applications. In this work, we studied the acute toxicity of graphite-diamond nanoparticles (GDN) combined with the fungicide thiabendazole (TBZ) to the immobilization of the cladoceran Daphnia magna in the presence and absence of the micro green algae Raphidocelis subcapitata, supplied as food source. The toxicity of GDN to D. magna decreased in the presence of R. subcapitata, while that of TBZ increased, the latter suggesting a carrier effect to TBZ. GDN-TBZ mixtures were fitted to the most common conceptual models applied to mixture toxicity: Concentration Addition (CA), Independent Action (IA) and Combination Index (CI). For GDN-TBZ mixtures in the absence of food the best fit was obtained with dose ratio deviation from CA model, while in the presence of food, dose level deviation from CA gave a better fit. The binary mixtures of GDN and TBZ showed synergistic toxic interactions at low concentrations, which could be attributed to the increased bioavailability of TBZ adsorbed on GDN. For higher concentrations of GDN, the binary mixtures turned antagonistic due to particle agglomeration. Our study provides evidence that deviations from additivity are dose dependent and relevant for the risk assessment of mixtures of nanoparticles with other chemical pollutants. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-20T00:00:00Z 2019-10-20 2023-04-11T15:39:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/36939 |
url |
http://hdl.handle.net/10773/36939 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0048-9697 10.1016/j.scitotenv.2019.06.316 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137730553184256 |