Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/131251 |
Resumo: | This article is protected by copyright. All rights reserved. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis5-year data from DESIRThis article is protected by copyright. All rights reserved.OBJECTIVE: To test the impact of inflammation on MRI-structural changes occurring in the sacroiliac joints (SIJ) and the spine. METHODS: Patients with early axSpA from the DESIR cohort were included. MRIs of the SIJ (MRI-SIJ) and spine (MRI-spine), obtained at baseline, 2 and 5 years, were scored by 3 central readers. Inflammation and structural damage on MRI-SIJ/MRI-spine were defined by the agreement of ≥2 of 3 readers (binary outcomes), and by the average of 3 readers (continuous outcomes). The effect of inflammation (MRI-SIJ/MRI-spine) on damage (MRI-SIJ/MRI-spine, respectively) was evaluated in two models: i. Baseline prediction model: effect of baseline inflammation on damage assessed at 5-year; and ii. Longitudinal model: effect of inflammation on structural damage assessed during 5 years. RESULTS: 202 patients were included. Both the presence of bone marrow edema (BME) on MRI-SIJ and on MRI-spine at baseline were predictive of 5-year damage (≥3 fatty lesions) on MRI-SIJ [OR=4.2 (95% CI: 2.4; 7.3)] and MRI-spine [OR=10.7 (95% CI: 2.4; 49.0)], respectively, when adjusted for CRP. The association was also confirmed in longitudinal models (when adjusted for ASDAS) both in the SIJ [OR=5.1 (95% CI: 2.7; 9.6)] and spine [OR=15.6 (95% CI: 4.8; 50.3)]. Analysis of other structural outcomes (i.e. erosions) on MRI-SIJ yielded similar results. In the spine, a significant association was found for fatty lesions but not for erosions and bone spurs, which occurred infrequently over time. CONCLUSION: We found a predictive and longitudinal association between MRI-inflammation and several types of MRI-structural damage in patients with early axSpA which adds to the proof for a causal relationship.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSepriano, AlexandreRamiro, SofiaLandewé, RobertMoltó, AnnaClaudepierre, PascalWendling, DanielDougados, Maximevan der Heijde, Désirée2022-01-21T00:14:10Z2022-022022-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/131251eng2151-464XPURE: 26055200https://doi.org/10.1002/acr.24449info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:09:47Zoai:run.unl.pt:10362/131251Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:47:01.279327Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis 5-year data from DESIR |
title |
Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis |
spellingShingle |
Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis Sepriano, Alexandre |
title_short |
Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis |
title_full |
Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis |
title_fullStr |
Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis |
title_full_unstemmed |
Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis |
title_sort |
Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis |
author |
Sepriano, Alexandre |
author_facet |
Sepriano, Alexandre Ramiro, Sofia Landewé, Robert Moltó, Anna Claudepierre, Pascal Wendling, Daniel Dougados, Maxime van der Heijde, Désirée |
author_role |
author |
author2 |
Ramiro, Sofia Landewé, Robert Moltó, Anna Claudepierre, Pascal Wendling, Daniel Dougados, Maxime van der Heijde, Désirée |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Sepriano, Alexandre Ramiro, Sofia Landewé, Robert Moltó, Anna Claudepierre, Pascal Wendling, Daniel Dougados, Maxime van der Heijde, Désirée |
description |
This article is protected by copyright. All rights reserved. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-21T00:14:10Z 2022-02 2022-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/131251 |
url |
http://hdl.handle.net/10362/131251 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2151-464X PURE: 26055200 https://doi.org/10.1002/acr.24449 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138073284444160 |