Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis

Detalhes bibliográficos
Autor(a) principal: Sepriano, Alexandre
Data de Publicação: 2022
Outros Autores: Ramiro, Sofia, Landewé, Robert, Moltó, Anna, Claudepierre, Pascal, Wendling, Daniel, Dougados, Maxime, van der Heijde, Désirée
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/131251
Resumo: This article is protected by copyright. All rights reserved.
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spelling Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis5-year data from DESIRThis article is protected by copyright. All rights reserved.OBJECTIVE: To test the impact of inflammation on MRI-structural changes occurring in the sacroiliac joints (SIJ) and the spine. METHODS: Patients with early axSpA from the DESIR cohort were included. MRIs of the SIJ (MRI-SIJ) and spine (MRI-spine), obtained at baseline, 2 and 5 years, were scored by 3 central readers. Inflammation and structural damage on MRI-SIJ/MRI-spine were defined by the agreement of ≥2 of 3 readers (binary outcomes), and by the average of 3 readers (continuous outcomes). The effect of inflammation (MRI-SIJ/MRI-spine) on damage (MRI-SIJ/MRI-spine, respectively) was evaluated in two models: i. Baseline prediction model: effect of baseline inflammation on damage assessed at 5-year; and ii. Longitudinal model: effect of inflammation on structural damage assessed during 5 years. RESULTS: 202 patients were included. Both the presence of bone marrow edema (BME) on MRI-SIJ and on MRI-spine at baseline were predictive of 5-year damage (≥3 fatty lesions) on MRI-SIJ [OR=4.2 (95% CI: 2.4; 7.3)] and MRI-spine [OR=10.7 (95% CI: 2.4; 49.0)], respectively, when adjusted for CRP. The association was also confirmed in longitudinal models (when adjusted for ASDAS) both in the SIJ [OR=5.1 (95% CI: 2.7; 9.6)] and spine [OR=15.6 (95% CI: 4.8; 50.3)]. Analysis of other structural outcomes (i.e. erosions) on MRI-SIJ yielded similar results. In the spine, a significant association was found for fatty lesions but not for erosions and bone spurs, which occurred infrequently over time. CONCLUSION: We found a predictive and longitudinal association between MRI-inflammation and several types of MRI-structural damage in patients with early axSpA which adds to the proof for a causal relationship.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSepriano, AlexandreRamiro, SofiaLandewé, RobertMoltó, AnnaClaudepierre, PascalWendling, DanielDougados, Maximevan der Heijde, Désirée2022-01-21T00:14:10Z2022-022022-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/131251eng2151-464XPURE: 26055200https://doi.org/10.1002/acr.24449info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:09:47Zoai:run.unl.pt:10362/131251Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:47:01.279327Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis
5-year data from DESIR
title Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis
spellingShingle Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis
Sepriano, Alexandre
title_short Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis
title_full Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis
title_fullStr Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis
title_full_unstemmed Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis
title_sort Inflammation of the sacroiliac joints and spine on MRI predicts structural changes on MRI in axial spondyloarthritis
author Sepriano, Alexandre
author_facet Sepriano, Alexandre
Ramiro, Sofia
Landewé, Robert
Moltó, Anna
Claudepierre, Pascal
Wendling, Daniel
Dougados, Maxime
van der Heijde, Désirée
author_role author
author2 Ramiro, Sofia
Landewé, Robert
Moltó, Anna
Claudepierre, Pascal
Wendling, Daniel
Dougados, Maxime
van der Heijde, Désirée
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Sepriano, Alexandre
Ramiro, Sofia
Landewé, Robert
Moltó, Anna
Claudepierre, Pascal
Wendling, Daniel
Dougados, Maxime
van der Heijde, Désirée
description This article is protected by copyright. All rights reserved.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-21T00:14:10Z
2022-02
2022-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/131251
url http://hdl.handle.net/10362/131251
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2151-464X
PURE: 26055200
https://doi.org/10.1002/acr.24449
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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