Outcomes assessed in trials of gout and accordance with OMERACT-proposed domains

Detalhes bibliográficos
Autor(a) principal: Araújo, Filipe
Data de Publicação: 2015
Outros Autores: Cordeiro, Inês, Ramiro, Sofia, Falzon, Louise, Branco, Jaime, Buchbinder, Rachelle
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/149785
Resumo: Publisher Copyright: © The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
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spelling Outcomes assessed in trials of gout and accordance with OMERACT-proposed domainsA systematic literature reviewGoutOutcomes researchPatient perspectiveRheumatologyPharmacology (medical)Publisher Copyright: © The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.Objective. The aim of this study was to systematically review outcome domains and measurement tools used in gout trials and their accordance with the preliminary OMERACT gout recommendations published in 2005.Methods. Randomized controlled trials (RCTs) and quasi-RCTs investigating any intervention for gout published up to February 2013 were included. Recruitment start dates and all measured outcomes were extracted. Risk of bias (RoB) was assessed with the Cochrane Collaboration tool. Numbers of OMERACT domains were compared for trials at low vs unclear/high RoB and for recruitment start date before 2005 or 2005 and later.Results. Of 9784 articles screened, 38 acute and 30 chronic gout trials were included. Mean (s.d.) number of OMERACT outcomes was 2.9 (1.1) (out of 5) and 2.5 (1.2) (out of 9) for acute and chronic gout trials, respectively. Health-related quality of life, participation and joint damage imaging were not assessed in any trial. Tools used to measure individual domains varied widely. There were no differences in the number of OMERACT outcomes reported in acute or chronic gout trials recruiting before 2005 vs 2005 or later [mean (s.d.): 3.0 (1.1) vs 3.5 (1.3), P = 0.859 and 2.7 (1.1) vs 2.8 (1.4), P = 0.960, respectively]. While both acute and chronic trials at low RoB reported more OMERACT domains than trials at unclear/high RoB, these differences were not significant. Industry-funded trials and trials performed by OMERACT investigators reported more OMERACT outcome domains.Conclusion. We found no appreciable impact of the OMERACT recommendations for gout trials to date.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNAraújo, FilipeCordeiro, InêsRamiro, SofiaFalzon, LouiseBranco, JaimeBuchbinder, Rachelle2023-02-27T22:21:32Z2015-06-012015-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13application/pdfhttp://hdl.handle.net/10362/149785eng1462-0324PURE: 47547386https://doi.org/10.1093/rheumatology/keu424info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:31:37Zoai:run.unl.pt:10362/149785Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:51.227781Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Outcomes assessed in trials of gout and accordance with OMERACT-proposed domains
A systematic literature review
title Outcomes assessed in trials of gout and accordance with OMERACT-proposed domains
spellingShingle Outcomes assessed in trials of gout and accordance with OMERACT-proposed domains
Araújo, Filipe
Gout
Outcomes research
Patient perspective
Rheumatology
Pharmacology (medical)
title_short Outcomes assessed in trials of gout and accordance with OMERACT-proposed domains
title_full Outcomes assessed in trials of gout and accordance with OMERACT-proposed domains
title_fullStr Outcomes assessed in trials of gout and accordance with OMERACT-proposed domains
title_full_unstemmed Outcomes assessed in trials of gout and accordance with OMERACT-proposed domains
title_sort Outcomes assessed in trials of gout and accordance with OMERACT-proposed domains
author Araújo, Filipe
author_facet Araújo, Filipe
Cordeiro, Inês
Ramiro, Sofia
Falzon, Louise
Branco, Jaime
Buchbinder, Rachelle
author_role author
author2 Cordeiro, Inês
Ramiro, Sofia
Falzon, Louise
Branco, Jaime
Buchbinder, Rachelle
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Araújo, Filipe
Cordeiro, Inês
Ramiro, Sofia
Falzon, Louise
Branco, Jaime
Buchbinder, Rachelle
dc.subject.por.fl_str_mv Gout
Outcomes research
Patient perspective
Rheumatology
Pharmacology (medical)
topic Gout
Outcomes research
Patient perspective
Rheumatology
Pharmacology (medical)
description Publisher Copyright: © The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-01
2015-06-01T00:00:00Z
2023-02-27T22:21:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/149785
url http://hdl.handle.net/10362/149785
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1462-0324
PURE: 47547386
https://doi.org/10.1093/rheumatology/keu424
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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