Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/68062 |
Resumo: | Supplementary Material available at: https://www.mdpi.com/2076-2607/8/11/1678/s1 |
id |
RCAP_68a6a7fbba915b293e98e825b97e40f9 |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/68062 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemicphylogeographyphylogenomicsmolecular epidemiologytravel bansintercontinental foundersSARS-COV-2 lineagesCOVID-19Ciências Médicas::Ciências da SaúdeScience & TechnologySupplementary Material available at: https://www.mdpi.com/2076-2607/8/11/1678/s1The novel coronavirus SARS-CoV-2 emerged from a zoonotic transmission in China towards the end of 2019, rapidly leading to a global pandemic on a scale not seen for a century. In order to cast fresh light on the spread of the virus and on the effectiveness of the containment measures adopted globally, we used 26,869 SARS-CoV-2 genomes to build a phylogeny with 20,247 mutation events and adopted a phylogeographic approach. We confirmed that the phylogeny pinpoints China as the origin of the pandemic with major founders worldwide, mainly during January 2020. However, a single specific East Asian founder underwent massive radiation in Europe and became the main actor of the subsequent spread worldwide during March 2020. This lineage accounts for the great majority of cases detected globally and even spread back to the source in East Asia. Despite an East Asian source, therefore, the global pandemic was mainly fueled by its expansion across and out of Europe. It seems likely that travel bans established throughout the world in the second half of March helped to decrease the number of intercontinental exchanges, particularly from mainland China, but were less effective between Europe and North America where exchanges in both directions are visible up to April, long after bans were imposed.This work was supported by strategic project ICVS/3B’s (UID/Multi/50025), financed by Fundação para a Ciência e Tecnologia/MCTES through national funds (PIDDAC) to Teresa Rito. Martin B. Richards and Maria Pala received support from a Leverhulme Doctoral Scholarship program. This work was partially supported by project NORTE-01-0145-FEDER000009) by Norte Portugal Regional Operational Program (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and by “Contrato-Programa” UIDB/04050/2020 funded by Portuguese national funds through the Fundação para a Ciência e Tecnologia to Pedro A. Soares.Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoRito, Teresa SRichards, Martin B.Pala, MariaCorreia-Neves, MSoares, Pedro2020-10-292020-10-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/68062engRito, T.; Richards, M.B.; Pala, M.; Correia-Neves, M.; Soares, P.A. Phylogeography of 27,000 SARS-CoV-2 Genomes: Europe as the Major Source of the COVID-19 Pandemic. Microorganisms 2020, 8, 1678. DOI: 10.3390/microorganisms81116782076-260710.3390/microorganisms8111678https://www.mdpi.com/2076-2607/8/11/1678info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:35:07Zoai:repositorium.sdum.uminho.pt:1822/68062Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:30:56.130606Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic |
title |
Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic |
spellingShingle |
Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic Rito, Teresa S phylogeography phylogenomics molecular epidemiology travel bans intercontinental founders SARS-COV-2 lineages COVID-19 Ciências Médicas::Ciências da Saúde Science & Technology |
title_short |
Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic |
title_full |
Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic |
title_fullStr |
Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic |
title_full_unstemmed |
Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic |
title_sort |
Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic |
author |
Rito, Teresa S |
author_facet |
Rito, Teresa S Richards, Martin B. Pala, Maria Correia-Neves, M Soares, Pedro |
author_role |
author |
author2 |
Richards, Martin B. Pala, Maria Correia-Neves, M Soares, Pedro |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Rito, Teresa S Richards, Martin B. Pala, Maria Correia-Neves, M Soares, Pedro |
dc.subject.por.fl_str_mv |
phylogeography phylogenomics molecular epidemiology travel bans intercontinental founders SARS-COV-2 lineages COVID-19 Ciências Médicas::Ciências da Saúde Science & Technology |
topic |
phylogeography phylogenomics molecular epidemiology travel bans intercontinental founders SARS-COV-2 lineages COVID-19 Ciências Médicas::Ciências da Saúde Science & Technology |
description |
Supplementary Material available at: https://www.mdpi.com/2076-2607/8/11/1678/s1 |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-10-29 2020-10-29T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/68062 |
url |
http://hdl.handle.net/1822/68062 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rito, T.; Richards, M.B.; Pala, M.; Correia-Neves, M.; Soares, P.A. Phylogeography of 27,000 SARS-CoV-2 Genomes: Europe as the Major Source of the COVID-19 Pandemic. Microorganisms 2020, 8, 1678. DOI: 10.3390/microorganisms8111678 2076-2607 10.3390/microorganisms8111678 https://www.mdpi.com/2076-2607/8/11/1678 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132815635251200 |