Pharmaceuticals released from senior residences: occurrence and risk evaluation
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10071/15630 |
Resumo: | One of the main pursuits, yet most difficult, in monitoring studies is to identify the sources of environmental pollution. In this study, we have identified health-care facilities from south European countries as an important source of pharmaceuticals in the environment. We have estimated that compounds consumed in by the elderly and released from effluents of senior residences can reach river waters at a concentration higher than 0.01 ?g/L, which is the European Medicines Agency (EMA) threshold for risk evaluation of pharmaceuticals in surface waters. This study has been based on five health institutions in Portugal, Spain, and France, with 52 to 130 beds. We have compiled the pharmaceuticals dispensed on a daily base and calculated the consumption rates. From 54.9 to 1801 g of pharmaceuticals are consumed daily, with laxatives, analgesics, antiepileptics, antibiotics, and antidiabetic agents being the main drug families administered. According to excretion rates, dilution in the sewerage system, and elimination in wastewater treatment plants, macrogol, metformin, paracetamol, acetylcysteine, amoxicillin, and gabapentin, among others, are expected to reach river waters. Finally, we discuss the risk management actions related to the discharge of pharmaceuticals from senior residences to surface waters. |
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Pharmaceuticals released from senior residences: occurrence and risk evaluationHealth care institutionsPharmaceuticalsPredicted environmental concentrationsRisk managementOne of the main pursuits, yet most difficult, in monitoring studies is to identify the sources of environmental pollution. In this study, we have identified health-care facilities from south European countries as an important source of pharmaceuticals in the environment. We have estimated that compounds consumed in by the elderly and released from effluents of senior residences can reach river waters at a concentration higher than 0.01 ?g/L, which is the European Medicines Agency (EMA) threshold for risk evaluation of pharmaceuticals in surface waters. This study has been based on five health institutions in Portugal, Spain, and France, with 52 to 130 beds. We have compiled the pharmaceuticals dispensed on a daily base and calculated the consumption rates. From 54.9 to 1801 g of pharmaceuticals are consumed daily, with laxatives, analgesics, antiepileptics, antibiotics, and antidiabetic agents being the main drug families administered. According to excretion rates, dilution in the sewerage system, and elimination in wastewater treatment plants, macrogol, metformin, paracetamol, acetylcysteine, amoxicillin, and gabapentin, among others, are expected to reach river waters. Finally, we discuss the risk management actions related to the discharge of pharmaceuticals from senior residences to surface waters.Springer2018-04-17T10:58:14Z2018-01-01T00:00:00Z20182019-03-08T10:34:07Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10071/15630eng0944-134410.1007/s11356-017-9755-1Lacorte, S.Luís, S.Gómez-Canela, C.Sala-Comorera, T.Courtier, A.Roig, B.Oliveira-Brett, A. M.Joannis-Cassan, C.Aragonés, J. I.Poggio, L.Noguer, T.Lima, M. L.Barata, C.Calas-Blanchard, C.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-09T17:32:41Zoai:repositorio.iscte-iul.pt:10071/15630Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:14:40.847273Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Pharmaceuticals released from senior residences: occurrence and risk evaluation |
title |
Pharmaceuticals released from senior residences: occurrence and risk evaluation |
spellingShingle |
Pharmaceuticals released from senior residences: occurrence and risk evaluation Lacorte, S. Health care institutions Pharmaceuticals Predicted environmental concentrations Risk management |
title_short |
Pharmaceuticals released from senior residences: occurrence and risk evaluation |
title_full |
Pharmaceuticals released from senior residences: occurrence and risk evaluation |
title_fullStr |
Pharmaceuticals released from senior residences: occurrence and risk evaluation |
title_full_unstemmed |
Pharmaceuticals released from senior residences: occurrence and risk evaluation |
title_sort |
Pharmaceuticals released from senior residences: occurrence and risk evaluation |
author |
Lacorte, S. |
author_facet |
Lacorte, S. Luís, S. Gómez-Canela, C. Sala-Comorera, T. Courtier, A. Roig, B. Oliveira-Brett, A. M. Joannis-Cassan, C. Aragonés, J. I. Poggio, L. Noguer, T. Lima, M. L. Barata, C. Calas-Blanchard, C. |
author_role |
author |
author2 |
Luís, S. Gómez-Canela, C. Sala-Comorera, T. Courtier, A. Roig, B. Oliveira-Brett, A. M. Joannis-Cassan, C. Aragonés, J. I. Poggio, L. Noguer, T. Lima, M. L. Barata, C. Calas-Blanchard, C. |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lacorte, S. Luís, S. Gómez-Canela, C. Sala-Comorera, T. Courtier, A. Roig, B. Oliveira-Brett, A. M. Joannis-Cassan, C. Aragonés, J. I. Poggio, L. Noguer, T. Lima, M. L. Barata, C. Calas-Blanchard, C. |
dc.subject.por.fl_str_mv |
Health care institutions Pharmaceuticals Predicted environmental concentrations Risk management |
topic |
Health care institutions Pharmaceuticals Predicted environmental concentrations Risk management |
description |
One of the main pursuits, yet most difficult, in monitoring studies is to identify the sources of environmental pollution. In this study, we have identified health-care facilities from south European countries as an important source of pharmaceuticals in the environment. We have estimated that compounds consumed in by the elderly and released from effluents of senior residences can reach river waters at a concentration higher than 0.01 ?g/L, which is the European Medicines Agency (EMA) threshold for risk evaluation of pharmaceuticals in surface waters. This study has been based on five health institutions in Portugal, Spain, and France, with 52 to 130 beds. We have compiled the pharmaceuticals dispensed on a daily base and calculated the consumption rates. From 54.9 to 1801 g of pharmaceuticals are consumed daily, with laxatives, analgesics, antiepileptics, antibiotics, and antidiabetic agents being the main drug families administered. According to excretion rates, dilution in the sewerage system, and elimination in wastewater treatment plants, macrogol, metformin, paracetamol, acetylcysteine, amoxicillin, and gabapentin, among others, are expected to reach river waters. Finally, we discuss the risk management actions related to the discharge of pharmaceuticals from senior residences to surface waters. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-04-17T10:58:14Z 2018-01-01T00:00:00Z 2018 2019-03-08T10:34:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10071/15630 |
url |
http://hdl.handle.net/10071/15630 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0944-1344 10.1007/s11356-017-9755-1 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134703814443008 |