Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/3778 https://doi.org/10.1016/j.supflu.2007.10.002 |
Resumo: | In this work, three chitosan derivatives (N-carboxymethyl chitosan (CMC), N-carboxybutyl chitosan (CBC) and N-succinyl chitosan (SCC)) were impregnated with flurbiprofen (an anti-inflammatory drug) and timolol maleate (an anti-glaucoma drug), using a supercritical solvent impregnation (SSI) technique (and employing high pressure CO2 and CO2 + EtOH mixtures) in order to develop hydrogel-type ophthalmic drug delivery applications. Impregnation experiments were carried out from 9.0 up to 14.0 MPa, and at 303.0, 313.0 and 323.0 K. The resulting polymeric drug delivery systems, as well as other polymeric samples processed in CO2, were characterized by FTIR spectroscopy and scanning electron microscopy (SEM). Drug release kinetics studies were performed for all prepared systems. The effects of impregnation pressure and temperature on the release kinetics results were studied and compared to the traditional soaking impregnation method. For the same operational conditions, results confirmed that the three different (chemically and physically) polymeric structures conditioned the impregnation and the drug release processes. Despite the final released drug mass is always the result of the employed operational impregnation conditions and of the very complex relative specific interactions that may occur between all species present in the system (drugs, polymers, CO2 and ethanol), results showed that, for N-carboxymethyl chitosan, the predominant effects in the impregnation process seemed to be the solubility of drugs in CO2 and in CO2 + EtOH mixtures, as well as the swelling and plasticizing effect of CO2 and ethanol on the polymer. Finally, the SSI method proved to be a more efficient and "tunable" impregnation process than the traditional impregnation of drugs by a soaking method. Therefore, and using this "tunable" SSI method, these N-chitosan derivatives-based ophthalmic drug delivery systems can be easily and efficiently prepared taking in consideration the desired drug levels according to patients needs. |
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Supercritical solvent impregnation of ophthalmic drugs on chitosan derivativesN-chitosan derivativesOphthalmic drug delivery systemsSupercritical solvent impregnation (SSI)FlurbiprofenTimolol maleateIn this work, three chitosan derivatives (N-carboxymethyl chitosan (CMC), N-carboxybutyl chitosan (CBC) and N-succinyl chitosan (SCC)) were impregnated with flurbiprofen (an anti-inflammatory drug) and timolol maleate (an anti-glaucoma drug), using a supercritical solvent impregnation (SSI) technique (and employing high pressure CO2 and CO2 + EtOH mixtures) in order to develop hydrogel-type ophthalmic drug delivery applications. Impregnation experiments were carried out from 9.0 up to 14.0 MPa, and at 303.0, 313.0 and 323.0 K. The resulting polymeric drug delivery systems, as well as other polymeric samples processed in CO2, were characterized by FTIR spectroscopy and scanning electron microscopy (SEM). Drug release kinetics studies were performed for all prepared systems. The effects of impregnation pressure and temperature on the release kinetics results were studied and compared to the traditional soaking impregnation method. For the same operational conditions, results confirmed that the three different (chemically and physically) polymeric structures conditioned the impregnation and the drug release processes. Despite the final released drug mass is always the result of the employed operational impregnation conditions and of the very complex relative specific interactions that may occur between all species present in the system (drugs, polymers, CO2 and ethanol), results showed that, for N-carboxymethyl chitosan, the predominant effects in the impregnation process seemed to be the solubility of drugs in CO2 and in CO2 + EtOH mixtures, as well as the swelling and plasticizing effect of CO2 and ethanol on the polymer. Finally, the SSI method proved to be a more efficient and "tunable" impregnation process than the traditional impregnation of drugs by a soaking method. Therefore, and using this "tunable" SSI method, these N-chitosan derivatives-based ophthalmic drug delivery systems can be easily and efficiently prepared taking in consideration the desired drug levels according to patients needs.http://www.sciencedirect.com/science/article/B6VMF-4PXM6CP-1/1/a112be9d86677ed00ff98cac80b9c39d2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/3778http://hdl.handle.net/10316/3778https://doi.org/10.1016/j.supflu.2007.10.002engThe Journal of Supercritical Fluids. 44:2 (2008) 245-257Braga, Mara E. M.Pato, Maria T. VazSilva, Hélio S. R. CostaFerreira, Elisabeth I.Gil, Maria H.Duarte, Catarina M. M.Sousa, Hermínio C. deinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-11-06T16:59:19Zoai:estudogeral.uc.pt:10316/3778Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:59:20.246329Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives |
title |
Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives |
spellingShingle |
Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives Braga, Mara E. M. N-chitosan derivatives Ophthalmic drug delivery systems Supercritical solvent impregnation (SSI) Flurbiprofen Timolol maleate |
title_short |
Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives |
title_full |
Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives |
title_fullStr |
Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives |
title_full_unstemmed |
Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives |
title_sort |
Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives |
author |
Braga, Mara E. M. |
author_facet |
Braga, Mara E. M. Pato, Maria T. Vaz Silva, Hélio S. R. Costa Ferreira, Elisabeth I. Gil, Maria H. Duarte, Catarina M. M. Sousa, Hermínio C. de |
author_role |
author |
author2 |
Pato, Maria T. Vaz Silva, Hélio S. R. Costa Ferreira, Elisabeth I. Gil, Maria H. Duarte, Catarina M. M. Sousa, Hermínio C. de |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Braga, Mara E. M. Pato, Maria T. Vaz Silva, Hélio S. R. Costa Ferreira, Elisabeth I. Gil, Maria H. Duarte, Catarina M. M. Sousa, Hermínio C. de |
dc.subject.por.fl_str_mv |
N-chitosan derivatives Ophthalmic drug delivery systems Supercritical solvent impregnation (SSI) Flurbiprofen Timolol maleate |
topic |
N-chitosan derivatives Ophthalmic drug delivery systems Supercritical solvent impregnation (SSI) Flurbiprofen Timolol maleate |
description |
In this work, three chitosan derivatives (N-carboxymethyl chitosan (CMC), N-carboxybutyl chitosan (CBC) and N-succinyl chitosan (SCC)) were impregnated with flurbiprofen (an anti-inflammatory drug) and timolol maleate (an anti-glaucoma drug), using a supercritical solvent impregnation (SSI) technique (and employing high pressure CO2 and CO2 + EtOH mixtures) in order to develop hydrogel-type ophthalmic drug delivery applications. Impregnation experiments were carried out from 9.0 up to 14.0 MPa, and at 303.0, 313.0 and 323.0 K. The resulting polymeric drug delivery systems, as well as other polymeric samples processed in CO2, were characterized by FTIR spectroscopy and scanning electron microscopy (SEM). Drug release kinetics studies were performed for all prepared systems. The effects of impregnation pressure and temperature on the release kinetics results were studied and compared to the traditional soaking impregnation method. For the same operational conditions, results confirmed that the three different (chemically and physically) polymeric structures conditioned the impregnation and the drug release processes. Despite the final released drug mass is always the result of the employed operational impregnation conditions and of the very complex relative specific interactions that may occur between all species present in the system (drugs, polymers, CO2 and ethanol), results showed that, for N-carboxymethyl chitosan, the predominant effects in the impregnation process seemed to be the solubility of drugs in CO2 and in CO2 + EtOH mixtures, as well as the swelling and plasticizing effect of CO2 and ethanol on the polymer. Finally, the SSI method proved to be a more efficient and "tunable" impregnation process than the traditional impregnation of drugs by a soaking method. Therefore, and using this "tunable" SSI method, these N-chitosan derivatives-based ophthalmic drug delivery systems can be easily and efficiently prepared taking in consideration the desired drug levels according to patients needs. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/3778 http://hdl.handle.net/10316/3778 https://doi.org/10.1016/j.supflu.2007.10.002 |
url |
http://hdl.handle.net/10316/3778 https://doi.org/10.1016/j.supflu.2007.10.002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
The Journal of Supercritical Fluids. 44:2 (2008) 245-257 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
aplication/PDF |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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