A newfangled collagenase inhibitor topical formulation based on Ethosomes with Sambucus nigra L. Extract
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/15502 |
Resumo: | Sambucus nigra L. (S. nigra) is a shrub widespread in Europe and western Asia, traditionally used in medicine, that has become popular in recent years as a potential source of a wide range of interesting bioactive compounds. The aim of the present work was to develop a topical S. nigra extract formulation based on ethosomes and thus to support its health claims with scientific evidence. S. nigra extract was prepared by an ultrasound-assisted method and then included in ethosomes. The ethosomes were analyzed in terms of their size, stability over time, morphology, entrapment capacity (EC), extract release profile, stability over time and several biological activities. The prepared ethosomes were indicated to be well defined, presenting sizes around 600 nm. The extract entrapment capacity in ethosomes was 73.9 ± 24.8%, with an interesting slow extract release profile over 24 h. The extract-loaded ethosomes presented collagenase inhibition activity and a very good skin compatibility after human application. This study demonstrates the potential use of S. nigra extract incorporated in ethosomes as a potential cosmeceutical ingredient and on further studies should be performed to better understand the impact of S. nigra compounds on skin care over the time. |
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7160 |
spelling |
A newfangled collagenase inhibitor topical formulation based on Ethosomes with Sambucus nigra L. ExtractSambucus nigra LEthosomesCollagenase inhibitionSkin compatibilitySambucus nigra L. (S. nigra) is a shrub widespread in Europe and western Asia, traditionally used in medicine, that has become popular in recent years as a potential source of a wide range of interesting bioactive compounds. The aim of the present work was to develop a topical S. nigra extract formulation based on ethosomes and thus to support its health claims with scientific evidence. S. nigra extract was prepared by an ultrasound-assisted method and then included in ethosomes. The ethosomes were analyzed in terms of their size, stability over time, morphology, entrapment capacity (EC), extract release profile, stability over time and several biological activities. The prepared ethosomes were indicated to be well defined, presenting sizes around 600 nm. The extract entrapment capacity in ethosomes was 73.9 ± 24.8%, with an interesting slow extract release profile over 24 h. The extract-loaded ethosomes presented collagenase inhibition activity and a very good skin compatibility after human application. This study demonstrates the potential use of S. nigra extract incorporated in ethosomes as a potential cosmeceutical ingredient and on further studies should be performed to better understand the impact of S. nigra compounds on skin care over the time.MDPISapientiaMota, Ana HenriquesPrazeres, InêsMestre, HenriqueBento-Silva, AndreiaRodrigues, Maria JoaoDuarte, NoéliaSerra, Ana TeresaBronze, Maria RosárioRijo, PatríciaGaspar, Maria ManuelaViana, Ana SilveiraAscensão, LiaPinto, PedroKumar, PradeepAlmeida, António JoséReis, Catarina Pinto2021-05-26T12:08:57Z2021-05-152021-05-24T15:03:40Z2021-05-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/15502engPharmaceuticals 14 (5): 467 (2021)10.3390/ph140504671424-8247info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:27:55Zoai:sapientia.ualg.pt:10400.1/15502Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:06:21.595465Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A newfangled collagenase inhibitor topical formulation based on Ethosomes with Sambucus nigra L. Extract |
title |
A newfangled collagenase inhibitor topical formulation based on Ethosomes with Sambucus nigra L. Extract |
spellingShingle |
A newfangled collagenase inhibitor topical formulation based on Ethosomes with Sambucus nigra L. Extract Mota, Ana Henriques Sambucus nigra L Ethosomes Collagenase inhibition Skin compatibility |
title_short |
A newfangled collagenase inhibitor topical formulation based on Ethosomes with Sambucus nigra L. Extract |
title_full |
A newfangled collagenase inhibitor topical formulation based on Ethosomes with Sambucus nigra L. Extract |
title_fullStr |
A newfangled collagenase inhibitor topical formulation based on Ethosomes with Sambucus nigra L. Extract |
title_full_unstemmed |
A newfangled collagenase inhibitor topical formulation based on Ethosomes with Sambucus nigra L. Extract |
title_sort |
A newfangled collagenase inhibitor topical formulation based on Ethosomes with Sambucus nigra L. Extract |
author |
Mota, Ana Henriques |
author_facet |
Mota, Ana Henriques Prazeres, Inês Mestre, Henrique Bento-Silva, Andreia Rodrigues, Maria Joao Duarte, Noélia Serra, Ana Teresa Bronze, Maria Rosário Rijo, Patrícia Gaspar, Maria Manuela Viana, Ana Silveira Ascensão, Lia Pinto, Pedro Kumar, Pradeep Almeida, António José Reis, Catarina Pinto |
author_role |
author |
author2 |
Prazeres, Inês Mestre, Henrique Bento-Silva, Andreia Rodrigues, Maria Joao Duarte, Noélia Serra, Ana Teresa Bronze, Maria Rosário Rijo, Patrícia Gaspar, Maria Manuela Viana, Ana Silveira Ascensão, Lia Pinto, Pedro Kumar, Pradeep Almeida, António José Reis, Catarina Pinto |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Mota, Ana Henriques Prazeres, Inês Mestre, Henrique Bento-Silva, Andreia Rodrigues, Maria Joao Duarte, Noélia Serra, Ana Teresa Bronze, Maria Rosário Rijo, Patrícia Gaspar, Maria Manuela Viana, Ana Silveira Ascensão, Lia Pinto, Pedro Kumar, Pradeep Almeida, António José Reis, Catarina Pinto |
dc.subject.por.fl_str_mv |
Sambucus nigra L Ethosomes Collagenase inhibition Skin compatibility |
topic |
Sambucus nigra L Ethosomes Collagenase inhibition Skin compatibility |
description |
Sambucus nigra L. (S. nigra) is a shrub widespread in Europe and western Asia, traditionally used in medicine, that has become popular in recent years as a potential source of a wide range of interesting bioactive compounds. The aim of the present work was to develop a topical S. nigra extract formulation based on ethosomes and thus to support its health claims with scientific evidence. S. nigra extract was prepared by an ultrasound-assisted method and then included in ethosomes. The ethosomes were analyzed in terms of their size, stability over time, morphology, entrapment capacity (EC), extract release profile, stability over time and several biological activities. The prepared ethosomes were indicated to be well defined, presenting sizes around 600 nm. The extract entrapment capacity in ethosomes was 73.9 ± 24.8%, with an interesting slow extract release profile over 24 h. The extract-loaded ethosomes presented collagenase inhibition activity and a very good skin compatibility after human application. This study demonstrates the potential use of S. nigra extract incorporated in ethosomes as a potential cosmeceutical ingredient and on further studies should be performed to better understand the impact of S. nigra compounds on skin care over the time. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-26T12:08:57Z 2021-05-15 2021-05-24T15:03:40Z 2021-05-15T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/15502 |
url |
http://hdl.handle.net/10400.1/15502 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmaceuticals 14 (5): 467 (2021) 10.3390/ph14050467 1424-8247 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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