Intrahepatic cholestasis in pregnancy. Its etiopathogenesis, prognosis and therapy.
Autor(a) principal: | |
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Data de Publicação: | 1994 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2871 |
Resumo: | Intrahepatic cholestasis of pregnancy (ICP) is a rare disease of unknown cause, recurrent, characterized by pruritus and, in some cases, mild jaundice. This cholestasis usually appears during the second half of pregnancy, and resolves in the early puerperium. ICP results in the elevation of serum total bile acids concentrations, mainly cholic acid, and abnormal routine liver function tests. Although maternal outcome is invariably good, an increased fetal risk has been reported, namely premature deliveries, fetal distress, and perinatal mortality. To avoid these deleterious consequences, strict fetal monitoring must be carried out during the final weeks of pregnancy, and the decision for delivery taken as soon as term or fetal maturity are achieved. The ursodeoxycholic acid (UDCA), that has been beneficial in other cholestatic liver diseases therapeutics, may become a promising drug in the treatment of ICP; nevertheless, due to the scarce experience with its use during ICP, and because its metabolism and mechanism of action is still poorly understood, it seems reasonable to test the effect of UDCA in these patients. |
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Intrahepatic cholestasis in pregnancy. Its etiopathogenesis, prognosis and therapy.Colestase intra-hepática da gravidez. Etiopatogénese, prognóstico e terapêutica.Intrahepatic cholestasis of pregnancy (ICP) is a rare disease of unknown cause, recurrent, characterized by pruritus and, in some cases, mild jaundice. This cholestasis usually appears during the second half of pregnancy, and resolves in the early puerperium. ICP results in the elevation of serum total bile acids concentrations, mainly cholic acid, and abnormal routine liver function tests. Although maternal outcome is invariably good, an increased fetal risk has been reported, namely premature deliveries, fetal distress, and perinatal mortality. To avoid these deleterious consequences, strict fetal monitoring must be carried out during the final weeks of pregnancy, and the decision for delivery taken as soon as term or fetal maturity are achieved. The ursodeoxycholic acid (UDCA), that has been beneficial in other cholestatic liver diseases therapeutics, may become a promising drug in the treatment of ICP; nevertheless, due to the scarce experience with its use during ICP, and because its metabolism and mechanism of action is still poorly understood, it seems reasonable to test the effect of UDCA in these patients.Intrahepatic cholestasis of pregnancy (ICP) is a rare disease of unknown cause, recurrent, characterized by pruritus and, in some cases, mild jaundice. This cholestasis usually appears during the second half of pregnancy, and resolves in the early puerperium. ICP results in the elevation of serum total bile acids concentrations, mainly cholic acid, and abnormal routine liver function tests. Although maternal outcome is invariably good, an increased fetal risk has been reported, namely premature deliveries, fetal distress, and perinatal mortality. To avoid these deleterious consequences, strict fetal monitoring must be carried out during the final weeks of pregnancy, and the decision for delivery taken as soon as term or fetal maturity are achieved. The ursodeoxycholic acid (UDCA), that has been beneficial in other cholestatic liver diseases therapeutics, may become a promising drug in the treatment of ICP; nevertheless, due to the scarce experience with its use during ICP, and because its metabolism and mechanism of action is still poorly understood, it seems reasonable to test the effect of UDCA in these patients.Ordem dos Médicos1994-03-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2871oai:ojs.www.actamedicaportuguesa.com:article/2871Acta Médica Portuguesa; Vol. 7 No. 3 (1994): Março; 181-8Acta Médica Portuguesa; Vol. 7 N.º 3 (1994): Março; 181-81646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2871https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2871/2256Brites, DPoeiras, JRodrigues, Cinfo:eu-repo/semantics/openAccess2022-12-20T11:01:16Zoai:ojs.www.actamedicaportuguesa.com:article/2871Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:18:02.045698Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Intrahepatic cholestasis in pregnancy. Its etiopathogenesis, prognosis and therapy. Colestase intra-hepática da gravidez. Etiopatogénese, prognóstico e terapêutica. |
title |
Intrahepatic cholestasis in pregnancy. Its etiopathogenesis, prognosis and therapy. |
spellingShingle |
Intrahepatic cholestasis in pregnancy. Its etiopathogenesis, prognosis and therapy. Brites, D |
title_short |
Intrahepatic cholestasis in pregnancy. Its etiopathogenesis, prognosis and therapy. |
title_full |
Intrahepatic cholestasis in pregnancy. Its etiopathogenesis, prognosis and therapy. |
title_fullStr |
Intrahepatic cholestasis in pregnancy. Its etiopathogenesis, prognosis and therapy. |
title_full_unstemmed |
Intrahepatic cholestasis in pregnancy. Its etiopathogenesis, prognosis and therapy. |
title_sort |
Intrahepatic cholestasis in pregnancy. Its etiopathogenesis, prognosis and therapy. |
author |
Brites, D |
author_facet |
Brites, D Poeiras, J Rodrigues, C |
author_role |
author |
author2 |
Poeiras, J Rodrigues, C |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Brites, D Poeiras, J Rodrigues, C |
description |
Intrahepatic cholestasis of pregnancy (ICP) is a rare disease of unknown cause, recurrent, characterized by pruritus and, in some cases, mild jaundice. This cholestasis usually appears during the second half of pregnancy, and resolves in the early puerperium. ICP results in the elevation of serum total bile acids concentrations, mainly cholic acid, and abnormal routine liver function tests. Although maternal outcome is invariably good, an increased fetal risk has been reported, namely premature deliveries, fetal distress, and perinatal mortality. To avoid these deleterious consequences, strict fetal monitoring must be carried out during the final weeks of pregnancy, and the decision for delivery taken as soon as term or fetal maturity are achieved. The ursodeoxycholic acid (UDCA), that has been beneficial in other cholestatic liver diseases therapeutics, may become a promising drug in the treatment of ICP; nevertheless, due to the scarce experience with its use during ICP, and because its metabolism and mechanism of action is still poorly understood, it seems reasonable to test the effect of UDCA in these patients. |
publishDate |
1994 |
dc.date.none.fl_str_mv |
1994-03-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2871 oai:ojs.www.actamedicaportuguesa.com:article/2871 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2871 |
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oai:ojs.www.actamedicaportuguesa.com:article/2871 |
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por |
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por |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2871 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2871/2256 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 7 No. 3 (1994): Março; 181-8 Acta Médica Portuguesa; Vol. 7 N.º 3 (1994): Março; 181-8 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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