Orchestrating mitochondria in neurons: Cytoskeleton as the conductor
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/49563 |
Resumo: | © 2019 The Authors. Cytoskeleton published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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Orchestrating mitochondria in neurons: Cytoskeleton as the conductorDockingMitochondriaNeuronal cytoskeletonSynapseTransport© 2019 The Authors. Cytoskeleton published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Mitochondria are crucial to support synaptic activity, particularly through ATP production and Ca2+ homeostasis. This implies that mitochondria need to be well distributed throughout the different neuronal sub-compartments. To achieve this, a tight and precise regulation of several neuronal cytoskeleton players is necessary to transport and dock mitochondria. As post-mitotic cells, neurons are highly dependent on mitochondrial quality control mechanisms and several cytoskeleton proteins have been implicated in mitophagy. Therefore, all of these processes are orchestrated by the crosstalk between mitochondria and the neuronal cytoskeleton to form a coordinated and tuned symphony.The authors are supported by Fundação para a Ciência e Tecnologia, Grant references for CCRPD/BD/135521/2018, AFP PD/BD/114113/2015, VAM IF/01693/2014, Funding reference: UID/BIM/50005/2019, project funded by Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through Fundos do Orçamento de Estado; by European Research Council, grant ERC-StG-679168; and European Molecular Biology Organization, grant EMBO-IG/3309.John Wiley & Sons, Inc.Repositório da Universidade de LisboaCardanho-Ramos, CarlosFaria-Pereira, AndreiaMorais, Vanessa A.2021-09-21T15:29:14Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49563engCytoskeleton (Hoboken). 2020 Mar;77(3-4):65-751949-358410.1002/cm.215851949-3592info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:53:27Zoai:repositorio.ul.pt:10451/49563Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:11.579805Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Orchestrating mitochondria in neurons: Cytoskeleton as the conductor |
title |
Orchestrating mitochondria in neurons: Cytoskeleton as the conductor |
spellingShingle |
Orchestrating mitochondria in neurons: Cytoskeleton as the conductor Cardanho-Ramos, Carlos Docking Mitochondria Neuronal cytoskeleton Synapse Transport |
title_short |
Orchestrating mitochondria in neurons: Cytoskeleton as the conductor |
title_full |
Orchestrating mitochondria in neurons: Cytoskeleton as the conductor |
title_fullStr |
Orchestrating mitochondria in neurons: Cytoskeleton as the conductor |
title_full_unstemmed |
Orchestrating mitochondria in neurons: Cytoskeleton as the conductor |
title_sort |
Orchestrating mitochondria in neurons: Cytoskeleton as the conductor |
author |
Cardanho-Ramos, Carlos |
author_facet |
Cardanho-Ramos, Carlos Faria-Pereira, Andreia Morais, Vanessa A. |
author_role |
author |
author2 |
Faria-Pereira, Andreia Morais, Vanessa A. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Cardanho-Ramos, Carlos Faria-Pereira, Andreia Morais, Vanessa A. |
dc.subject.por.fl_str_mv |
Docking Mitochondria Neuronal cytoskeleton Synapse Transport |
topic |
Docking Mitochondria Neuronal cytoskeleton Synapse Transport |
description |
© 2019 The Authors. Cytoskeleton published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z 2021-09-21T15:29:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/49563 |
url |
http://hdl.handle.net/10451/49563 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cytoskeleton (Hoboken). 2020 Mar;77(3-4):65-75 1949-3584 10.1002/cm.21585 1949-3592 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
John Wiley & Sons, Inc. |
publisher.none.fl_str_mv |
John Wiley & Sons, Inc. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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