From thymus to periphery : molecular basis of effector γδ‐T cell differentiation

Detalhes bibliográficos
Autor(a) principal: Fiala, Gina
Data de Publicação: 2020
Outros Autores: Gomes, Anita Q., Silva-Santos, Bruno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/47288
Resumo: © 2020 The Authors. Immunological Reviews published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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spelling From thymus to periphery : molecular basis of effector γδ‐T cell differentiationEffector T cell differentiationGamma-delta T cellsIL-17Thymic T cell development© 2020 The Authors. Immunological Reviews published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.The contributions of γδ T cells to immune (patho)physiology in many pre-clinical mouse models have been associated with their rapid and abundant provision of two critical cytokines, interferon-γ (IFN-γ) and interleukin-17A (IL-17). These are typically produced by distinct effector γδ T cell subsets that can be segregated on the basis of surface expression levels of receptors such as CD27, CD44 or CD45RB, among others. Unlike conventional T cells that egress the thymus as naïve lymphocytes awaiting further differentiation upon activation, a large fraction of murine γδ T cells commits to either IFN-γ or IL-17 expression during thymic development. However, extrathymic signals can both regulate pre-programmed γδ T cells; and induce peripheral differentiation of naïve γδ T cells into effectors. Here we review the key cellular events of "developmental pre-programming" in the mouse thymus; and the molecular basis for effector function maintenance vs plasticity in the periphery. We highlight some of our contributions towards elucidating the role of T cell receptor, co-receptors (like CD27 and CD28) and cytokine signals (such as IL-1β and IL-23) in these processes, and the various levels of gene regulation involved, from the chromatin landscape to microRNA-based post-transcriptional control of γδ T cell functional plasticity.This work was funded by the European Research Council (CoG_646701 to BS‐S.). GJF is supported by a European Commission Marie Sklodowska‐Curie Individual Fellowship (ref. 752932).John Wiley & Sons, Inc.Repositório da Universidade de LisboaFiala, GinaGomes, Anita Q.Silva-Santos, Bruno2021-04-08T12:52:30Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47288engImmunol Rev. 2020 Nov;298(1):47-600105-289610.1111/imr.129181600-065Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:50:07Zoai:repositorio.ul.pt:10451/47288Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:22.277070Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv From thymus to periphery : molecular basis of effector γδ‐T cell differentiation
title From thymus to periphery : molecular basis of effector γδ‐T cell differentiation
spellingShingle From thymus to periphery : molecular basis of effector γδ‐T cell differentiation
Fiala, Gina
Effector T cell differentiation
Gamma-delta T cells
IL-17
Thymic T cell development
title_short From thymus to periphery : molecular basis of effector γδ‐T cell differentiation
title_full From thymus to periphery : molecular basis of effector γδ‐T cell differentiation
title_fullStr From thymus to periphery : molecular basis of effector γδ‐T cell differentiation
title_full_unstemmed From thymus to periphery : molecular basis of effector γδ‐T cell differentiation
title_sort From thymus to periphery : molecular basis of effector γδ‐T cell differentiation
author Fiala, Gina
author_facet Fiala, Gina
Gomes, Anita Q.
Silva-Santos, Bruno
author_role author
author2 Gomes, Anita Q.
Silva-Santos, Bruno
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Fiala, Gina
Gomes, Anita Q.
Silva-Santos, Bruno
dc.subject.por.fl_str_mv Effector T cell differentiation
Gamma-delta T cells
IL-17
Thymic T cell development
topic Effector T cell differentiation
Gamma-delta T cells
IL-17
Thymic T cell development
description © 2020 The Authors. Immunological Reviews published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-04-08T12:52:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/47288
url http://hdl.handle.net/10451/47288
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Immunol Rev. 2020 Nov;298(1):47-60
0105-2896
10.1111/imr.12918
1600-065X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons, Inc.
publisher.none.fl_str_mv John Wiley & Sons, Inc.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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