Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour
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Publication Date: | 2017 |
Other Authors: | , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713 |
Summary: | The carcinoid syndrome is rare but it is associated with carcinoid heart disease in more than a half of the cases. Carcinoid heart disease is typically characterised by morphological and functional modifications of right-sided valves. Its aetiology is probable multifactorial but serotonin appears to play a key role in the development of this valvular disease. Unlike gastrointestinal neuroendocrine tumours, ovarian neuroendocrine tumours can present with carcinoid syndrome and carcinoid heart disease in the absence of liver metastases; such ovarian neuroendocrine tumours are a unique clinical entity. The additional burden of cardiac impairment in these patients represents a significant reduction in survival. Early recognition and surgical valve replacement before advanced heart failure is established may improve the clinical outcome. We report the case of a woman with an ovarian neuroendocrine tumour and highly symptomatic carcinoid heart disease who was submitted to tumour resection followed by valvuloplasty. She demonstrated an outstanding clinical improvement and has remained free of tumour and symptomatology. |
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Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine TumourSíndrome Carcinoide e Doença Carcinoide Cardíaca como Manifestações de Tumor Neuroendócrino do Ovário Não MetastáticoCarcinomaNeuroendocrineCarcinoid Heart DiseaseCarcinoid TumorOvarian NeoplasmsCarcinoma NeuroendócrinoDoença Carcinoide CardíacaNeoplasias do OvárioTumor CarcinoideThe carcinoid syndrome is rare but it is associated with carcinoid heart disease in more than a half of the cases. Carcinoid heart disease is typically characterised by morphological and functional modifications of right-sided valves. Its aetiology is probable multifactorial but serotonin appears to play a key role in the development of this valvular disease. Unlike gastrointestinal neuroendocrine tumours, ovarian neuroendocrine tumours can present with carcinoid syndrome and carcinoid heart disease in the absence of liver metastases; such ovarian neuroendocrine tumours are a unique clinical entity. The additional burden of cardiac impairment in these patients represents a significant reduction in survival. Early recognition and surgical valve replacement before advanced heart failure is established may improve the clinical outcome. We report the case of a woman with an ovarian neuroendocrine tumour and highly symptomatic carcinoid heart disease who was submitted to tumour resection followed by valvuloplasty. She demonstrated an outstanding clinical improvement and has remained free of tumour and symptomatology.A síndrome carcinoide é rara mas encontra-se associada, em cerca de metade dos casos, a doença carcinoide cardíaca. Esta patologia cardíaca caracteriza-se tipicamente por alterações morfo-funcionais das válvulas direitas. A sua etiologia é provavelmente multifatorial mas, aparentemente, a serotonina parece exercer um papel preponderante no desenvolvimento desta doença valvular. Ao contrário dos tumores neuroendócrinos gastrointestinais, os tumores neuroendócrinos do ovário podem apresentar síndrome carcinoide e doença carcinoide cardíaca na ausência de metastização hepática, tornando os tumores neuroendócrinos do ovário uma entidade clínica única. Estas alterações cardíacas acarretam uma diminuição adicional da sobrevivência destes doentes. Portanto, o reconhecimento precoce desta entidade e a substituição valvular prévia ao estabelecimento da insuficiência cardíaca avançada podem melhorar a evolução clínica destes doentes. Os autores apresentam o caso de uma mulher com tumor neuroendócrino do ovário e doença carcinoide cardíaca muito sintomática que foi submetida a resseção tumoral seguida de valvuloplastia. A doente demonstrou uma marcada melhoria clínica e tem permanecido livre de doença e assintomática.Ordem dos Médicos2017-05-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfimage/jpegapplication/mswordimage/jpegimage/jpegimage/jpegimage/jpegapplication/mswordapplication/mswordimage/tiffimage/tiffimage/jpegimage/jpegimage/jpegapplication/pdfapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713oai:ojs.www.actamedicaportuguesa.com:article/7713Acta Médica Portuguesa; Vol. 30 No. 5 (2017): May; 421-425Acta Médica Portuguesa; Vol. 30 N.º 5 (2017): Maio; 421-4251646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/5051https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8421https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8422https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8736https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8737https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8738https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8739https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8740https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8864https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8865https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8866https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8867https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8868https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8869https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8914https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8915Direitos de Autor (c) 2017 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessSimões-Pereira, JoanaWang, Lai MunKardos, AttilaGrossman, Ashley2022-12-20T11:05:18Zoai:ojs.www.actamedicaportuguesa.com:article/7713Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:29.504121Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour Síndrome Carcinoide e Doença Carcinoide Cardíaca como Manifestações de Tumor Neuroendócrino do Ovário Não Metastático |
title |
Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour |
spellingShingle |
Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour Simões-Pereira, Joana Carcinoma Neuroendocrine Carcinoid Heart Disease Carcinoid Tumor Ovarian Neoplasms Carcinoma Neuroendócrino Doença Carcinoide Cardíaca Neoplasias do Ovário Tumor Carcinoide |
title_short |
Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour |
title_full |
Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour |
title_fullStr |
Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour |
title_full_unstemmed |
Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour |
title_sort |
Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour |
author |
Simões-Pereira, Joana |
author_facet |
Simões-Pereira, Joana Wang, Lai Mun Kardos, Attila Grossman, Ashley |
author_role |
author |
author2 |
Wang, Lai Mun Kardos, Attila Grossman, Ashley |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Simões-Pereira, Joana Wang, Lai Mun Kardos, Attila Grossman, Ashley |
dc.subject.por.fl_str_mv |
Carcinoma Neuroendocrine Carcinoid Heart Disease Carcinoid Tumor Ovarian Neoplasms Carcinoma Neuroendócrino Doença Carcinoide Cardíaca Neoplasias do Ovário Tumor Carcinoide |
topic |
Carcinoma Neuroendocrine Carcinoid Heart Disease Carcinoid Tumor Ovarian Neoplasms Carcinoma Neuroendócrino Doença Carcinoide Cardíaca Neoplasias do Ovário Tumor Carcinoide |
description |
The carcinoid syndrome is rare but it is associated with carcinoid heart disease in more than a half of the cases. Carcinoid heart disease is typically characterised by morphological and functional modifications of right-sided valves. Its aetiology is probable multifactorial but serotonin appears to play a key role in the development of this valvular disease. Unlike gastrointestinal neuroendocrine tumours, ovarian neuroendocrine tumours can present with carcinoid syndrome and carcinoid heart disease in the absence of liver metastases; such ovarian neuroendocrine tumours are a unique clinical entity. The additional burden of cardiac impairment in these patients represents a significant reduction in survival. Early recognition and surgical valve replacement before advanced heart failure is established may improve the clinical outcome. We report the case of a woman with an ovarian neuroendocrine tumour and highly symptomatic carcinoid heart disease who was submitted to tumour resection followed by valvuloplasty. She demonstrated an outstanding clinical improvement and has remained free of tumour and symptomatology. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-05-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713 oai:ojs.www.actamedicaportuguesa.com:article/7713 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/7713 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/5051 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8421 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8422 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8736 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8737 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8738 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8739 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8740 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8864 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8865 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8866 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8867 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8868 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8869 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8914 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8915 |
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Direitos de Autor (c) 2017 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
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Direitos de Autor (c) 2017 Acta Médica Portuguesa |
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Ordem dos Médicos |
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Ordem dos Médicos |
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Acta Médica Portuguesa; Vol. 30 No. 5 (2017): May; 421-425 Acta Médica Portuguesa; Vol. 30 N.º 5 (2017): Maio; 421-425 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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