Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.7/622 |
Resumo: | The tremendous diversity of leaf shapes has caught the attention of naturalists for centuries. In addition to interspecific and intraspecific differences, leaf morphologies may differ in single plants according to age, a phenomenon known as heteroblasty. In Arabidopsis thaliana, the progression from the juvenile to the adult phase is characterized by increased leaf serration. A similar trend is seen in species with more complex leaves, such as the A. thaliana relative Cardamine hirsuta, in which the number of leaflets per leaf increases with age. Although the genetic changes that led to the overall simpler leaf architecture in A. thaliana are increasingly well understood, less is known about the events underlying age-dependent changes within single plants, in either A. thaliana or C. hirsuta. Here, we describe a conserved miRNA transcription factor regulon responsible for an age-dependent increase in leaf complexity. In early leaves, miR319-targeted TCP transcription factors interfere with the function of miR164-dependent and miR164-independent CUC proteins, preventing the formation of serrations in A. thaliana and of leaflets in C. hirsuta. As plants age, accumulation of miR156-regulated SPLs acts as a timing cue that destabilizes TCP-CUC interactions. The destabilization licenses activation of CUC protein complexes and thereby the gradual increase of leaf complexity in the newly formed organs. These findings point to posttranslational interaction between unrelated miRNA-targeted transcription factors as a core feature of these regulatory circuits. |
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Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein ComplexesArabidopsisArabidopsis ProteinsGene Expression Regulation, DevelopmentalGene Expression Regulation, PlantMicroRNAsPlant DevelopmentPlant LeavesSpecies SpecificityTime FactorsThe tremendous diversity of leaf shapes has caught the attention of naturalists for centuries. In addition to interspecific and intraspecific differences, leaf morphologies may differ in single plants according to age, a phenomenon known as heteroblasty. In Arabidopsis thaliana, the progression from the juvenile to the adult phase is characterized by increased leaf serration. A similar trend is seen in species with more complex leaves, such as the A. thaliana relative Cardamine hirsuta, in which the number of leaflets per leaf increases with age. Although the genetic changes that led to the overall simpler leaf architecture in A. thaliana are increasingly well understood, less is known about the events underlying age-dependent changes within single plants, in either A. thaliana or C. hirsuta. Here, we describe a conserved miRNA transcription factor regulon responsible for an age-dependent increase in leaf complexity. In early leaves, miR319-targeted TCP transcription factors interfere with the function of miR164-dependent and miR164-independent CUC proteins, preventing the formation of serrations in A. thaliana and of leaflets in C. hirsuta. As plants age, accumulation of miR156-regulated SPLs acts as a timing cue that destabilizes TCP-CUC interactions. The destabilization licenses activation of CUC protein complexes and thereby the gradual increase of leaf complexity in the newly formed organs. These findings point to posttranslational interaction between unrelated miRNA-targeted transcription factors as a core feature of these regulatory circuits.European Molecular Biology Organization (EMBO) fellowship; Fundação para a Ciência e a Tecnologia fellowships; EMBO Installation Grant; National Natural Science Foundation of China grants: (31222029, 912173023); State Key Basic Research Program of China grant: (2013CB127000); Deutsche Forschungsgemeinschaft grants: (SPP1530 and a Gottfried Wilhelm Leibniz Award); Max Planck Society.Cell PressARCARubio-Somoza, IgnacioZhou, Chuan-MiaoConfraria, AnaMartinho, Claudiavon Born, PatrickBaena-Gonzalez, ElenaWang, Jia-WeiWeigel, Detlef2016-06-07T11:41:24Z2014-11-172014-11-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/622engIgnacio Rubio-Somoza, Chuan-Miao Zhou, Ana Confraria, Claudia Martinho, Patrick von Born, Elena Baena-Gonzalez, Jia-Wei Wang, Detlef Weigel, Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes, Current Biology, Volume 24, Issue 22, 17 November 2014, Pages 2714-2719, ISSN 0960-9822, http://dx.doi.org/10.1016/j.cub.2014.09.058.10.1016/j.cub.2014.09.058info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:00Zoai:arca.igc.gulbenkian.pt:10400.7/622Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:51.951147Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes |
title |
Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes |
spellingShingle |
Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes Rubio-Somoza, Ignacio Arabidopsis Arabidopsis Proteins Gene Expression Regulation, Developmental Gene Expression Regulation, Plant MicroRNAs Plant Development Plant Leaves Species Specificity Time Factors |
title_short |
Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes |
title_full |
Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes |
title_fullStr |
Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes |
title_full_unstemmed |
Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes |
title_sort |
Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes |
author |
Rubio-Somoza, Ignacio |
author_facet |
Rubio-Somoza, Ignacio Zhou, Chuan-Miao Confraria, Ana Martinho, Claudia von Born, Patrick Baena-Gonzalez, Elena Wang, Jia-Wei Weigel, Detlef |
author_role |
author |
author2 |
Zhou, Chuan-Miao Confraria, Ana Martinho, Claudia von Born, Patrick Baena-Gonzalez, Elena Wang, Jia-Wei Weigel, Detlef |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
ARCA |
dc.contributor.author.fl_str_mv |
Rubio-Somoza, Ignacio Zhou, Chuan-Miao Confraria, Ana Martinho, Claudia von Born, Patrick Baena-Gonzalez, Elena Wang, Jia-Wei Weigel, Detlef |
dc.subject.por.fl_str_mv |
Arabidopsis Arabidopsis Proteins Gene Expression Regulation, Developmental Gene Expression Regulation, Plant MicroRNAs Plant Development Plant Leaves Species Specificity Time Factors |
topic |
Arabidopsis Arabidopsis Proteins Gene Expression Regulation, Developmental Gene Expression Regulation, Plant MicroRNAs Plant Development Plant Leaves Species Specificity Time Factors |
description |
The tremendous diversity of leaf shapes has caught the attention of naturalists for centuries. In addition to interspecific and intraspecific differences, leaf morphologies may differ in single plants according to age, a phenomenon known as heteroblasty. In Arabidopsis thaliana, the progression from the juvenile to the adult phase is characterized by increased leaf serration. A similar trend is seen in species with more complex leaves, such as the A. thaliana relative Cardamine hirsuta, in which the number of leaflets per leaf increases with age. Although the genetic changes that led to the overall simpler leaf architecture in A. thaliana are increasingly well understood, less is known about the events underlying age-dependent changes within single plants, in either A. thaliana or C. hirsuta. Here, we describe a conserved miRNA transcription factor regulon responsible for an age-dependent increase in leaf complexity. In early leaves, miR319-targeted TCP transcription factors interfere with the function of miR164-dependent and miR164-independent CUC proteins, preventing the formation of serrations in A. thaliana and of leaflets in C. hirsuta. As plants age, accumulation of miR156-regulated SPLs acts as a timing cue that destabilizes TCP-CUC interactions. The destabilization licenses activation of CUC protein complexes and thereby the gradual increase of leaf complexity in the newly formed organs. These findings point to posttranslational interaction between unrelated miRNA-targeted transcription factors as a core feature of these regulatory circuits. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-11-17 2014-11-17T00:00:00Z 2016-06-07T11:41:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/622 |
url |
http://hdl.handle.net/10400.7/622 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ignacio Rubio-Somoza, Chuan-Miao Zhou, Ana Confraria, Claudia Martinho, Patrick von Born, Elena Baena-Gonzalez, Jia-Wei Wang, Detlef Weigel, Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes, Current Biology, Volume 24, Issue 22, 17 November 2014, Pages 2714-2719, ISSN 0960-9822, http://dx.doi.org/10.1016/j.cub.2014.09.058. 10.1016/j.cub.2014.09.058 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Cell Press |
publisher.none.fl_str_mv |
Cell Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130573796540416 |