Effect of blood type on anti-a-Gal immunity and the incidence of infectious diseases

Detalhes bibliográficos
Autor(a) principal: Neves, Margarida Correia
Data de Publicação: 2017
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/49065
Resumo: The identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility to malaria and other infectious diseases. Due to the structural similarity between blood antigen B and Gal alpha 1-3Gal beta 1-(3)4GlcNAc-R (alpha-Gal), we hypothesized that self-tolerance to antigen B affects the immune response to alpha-Gal, which in turn affects the susceptibility to infectious diseases caused by pathogens carrying alpha-Gal on their surface. Here we found that the incidence of malaria and tuberculosis, caused by pathogens with alpha-Gal on their surface, positively correlates with the frequency of blood type B in endemic regions. However, the incidence of dengue fever, caused by a pathogen without alpha-Gal, was not related to the frequency of blood type B in these populations. Furthermore, the incidence of malaria and tuberculosis was negatively correlated with the anti-alpha-Gal antibody protective response. These results have implications for disease control and prevention.
id RCAP_7e29bb82a63df083834be047b3cf0f5c
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/49065
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Effect of blood type on anti-a-Gal immunity and the incidence of infectious diseasesScience & TechnologyThe identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility to malaria and other infectious diseases. Due to the structural similarity between blood antigen B and Gal alpha 1-3Gal beta 1-(3)4GlcNAc-R (alpha-Gal), we hypothesized that self-tolerance to antigen B affects the immune response to alpha-Gal, which in turn affects the susceptibility to infectious diseases caused by pathogens carrying alpha-Gal on their surface. Here we found that the incidence of malaria and tuberculosis, caused by pathogens with alpha-Gal on their surface, positively correlates with the frequency of blood type B in endemic regions. However, the incidence of dengue fever, caused by a pathogen without alpha-Gal, was not related to the frequency of blood type B in these populations. Furthermore, the incidence of malaria and tuberculosis was negatively correlated with the anti-alpha-Gal antibody protective response. These results have implications for disease control and prevention.The research was partially supported by the European Union projects, ANTIcipating the Global Onset of Novel Epidemics (ANTIGONE) project number 278976, and the COllaborative Management Platform for detection and Analyses of (Re-) emerging and foodborne outbreaks in Europe (COMPARE) Grant 643476. We thank Vladimir Lopez (IREC, Spain) for the contribution of M. marinum samples and Jose Alberto Garcia Seco (Hospital General Universitario de Ciudad Real, Spain) for technical assistance.info:eu-repo/semantics/publishedVersionNature Publishing Group[et al.]Universidade do MinhoNeves, Margarida Correia2017-01-102017-01-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/49065eng2092-641310.1038/emm.2016.16428280265https://www.nature.com/emm/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:59:49Zoai:repositorium.sdum.uminho.pt:1822/49065Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:49:37.570788Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effect of blood type on anti-a-Gal immunity and the incidence of infectious diseases
title Effect of blood type on anti-a-Gal immunity and the incidence of infectious diseases
spellingShingle Effect of blood type on anti-a-Gal immunity and the incidence of infectious diseases
Neves, Margarida Correia
Science & Technology
title_short Effect of blood type on anti-a-Gal immunity and the incidence of infectious diseases
title_full Effect of blood type on anti-a-Gal immunity and the incidence of infectious diseases
title_fullStr Effect of blood type on anti-a-Gal immunity and the incidence of infectious diseases
title_full_unstemmed Effect of blood type on anti-a-Gal immunity and the incidence of infectious diseases
title_sort Effect of blood type on anti-a-Gal immunity and the incidence of infectious diseases
author Neves, Margarida Correia
author_facet Neves, Margarida Correia
author_role author
dc.contributor.none.fl_str_mv [et al.]
Universidade do Minho
dc.contributor.author.fl_str_mv Neves, Margarida Correia
dc.subject.por.fl_str_mv Science & Technology
topic Science & Technology
description The identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility to malaria and other infectious diseases. Due to the structural similarity between blood antigen B and Gal alpha 1-3Gal beta 1-(3)4GlcNAc-R (alpha-Gal), we hypothesized that self-tolerance to antigen B affects the immune response to alpha-Gal, which in turn affects the susceptibility to infectious diseases caused by pathogens carrying alpha-Gal on their surface. Here we found that the incidence of malaria and tuberculosis, caused by pathogens with alpha-Gal on their surface, positively correlates with the frequency of blood type B in endemic regions. However, the incidence of dengue fever, caused by a pathogen without alpha-Gal, was not related to the frequency of blood type B in these populations. Furthermore, the incidence of malaria and tuberculosis was negatively correlated with the anti-alpha-Gal antibody protective response. These results have implications for disease control and prevention.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-10
2017-01-10T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/49065
url http://hdl.handle.net/1822/49065
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2092-6413
10.1038/emm.2016.164
28280265
https://www.nature.com/emm/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132262145458176

Registros relacionados