Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma haematobium immature worms
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/199 |
Resumo: | Golden hamsters were inoculated with Schistosoma haematobium cercariae to examine histological lesions at different time points over an 18 month period of infection. Hamsters were sacrificed 26 weeks and 82 weeks after inoculation. The parasite was found in the blood and in the liver of infected animals as was expected, but we found exclusively male worms, no female worms nor eggs. Interestingly we observed unexpected hepatic lesions induced by S. haematobium immature male worms alone in the golden hamster, characteristic of schistosome eggs. Samples from liver, kidneys, lungs, bladder and gastrointestinal tract were collected during necropsy to evaluate injuries induced by S. haematobium. Notably we observed hepatitis in the liver of infected hamsters, no lesions were found in other organs. We also found liver fibrosis in infected hamsters. This study provides further experimental evidence for the role that schistosome worms, and their derived antigens, may play in the pathology of the infection and modulation of liver chronic inflammation in the murine model of schistosomiasis. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma haematobium immature wormsSchistosoma haematobiumAdult wormsLiver lesionsLiver fibrosisInfecções Sistémicas e ZoonosesGolden hamsters were inoculated with Schistosoma haematobium cercariae to examine histological lesions at different time points over an 18 month period of infection. Hamsters were sacrificed 26 weeks and 82 weeks after inoculation. The parasite was found in the blood and in the liver of infected animals as was expected, but we found exclusively male worms, no female worms nor eggs. Interestingly we observed unexpected hepatic lesions induced by S. haematobium immature male worms alone in the golden hamster, characteristic of schistosome eggs. Samples from liver, kidneys, lungs, bladder and gastrointestinal tract were collected during necropsy to evaluate injuries induced by S. haematobium. Notably we observed hepatitis in the liver of infected hamsters, no lesions were found in other organs. We also found liver fibrosis in infected hamsters. This study provides further experimental evidence for the role that schistosome worms, and their derived antigens, may play in the pathology of the infection and modulation of liver chronic inflammation in the murine model of schistosomiasis.Landes BioscienceRepositório Científico do Instituto Nacional de SaúdeBotelho, Mónica C.Oliveira, Paula A.Vieira, PauloDelgado, Maria de LurdesLourenço, LigiaLopes, CarlosMachado, José C .Costa, José M Correia da2011-09-19T12:21:52Z2010-052010-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/199engVirulence. 2010 May-Jun;1(3):123-92150-5594info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:38:03Zoai:repositorio.insa.pt:10400.18/199Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:35:24.967548Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma haematobium immature worms |
title |
Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma haematobium immature worms |
spellingShingle |
Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma haematobium immature worms Botelho, Mónica C. Schistosoma haematobium Adult worms Liver lesions Liver fibrosis Infecções Sistémicas e Zoonoses |
title_short |
Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma haematobium immature worms |
title_full |
Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma haematobium immature worms |
title_fullStr |
Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma haematobium immature worms |
title_full_unstemmed |
Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma haematobium immature worms |
title_sort |
Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma haematobium immature worms |
author |
Botelho, Mónica C. |
author_facet |
Botelho, Mónica C. Oliveira, Paula A. Vieira, Paulo Delgado, Maria de Lurdes Lourenço, Ligia Lopes, Carlos Machado, José C . Costa, José M Correia da |
author_role |
author |
author2 |
Oliveira, Paula A. Vieira, Paulo Delgado, Maria de Lurdes Lourenço, Ligia Lopes, Carlos Machado, José C . Costa, José M Correia da |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Botelho, Mónica C. Oliveira, Paula A. Vieira, Paulo Delgado, Maria de Lurdes Lourenço, Ligia Lopes, Carlos Machado, José C . Costa, José M Correia da |
dc.subject.por.fl_str_mv |
Schistosoma haematobium Adult worms Liver lesions Liver fibrosis Infecções Sistémicas e Zoonoses |
topic |
Schistosoma haematobium Adult worms Liver lesions Liver fibrosis Infecções Sistémicas e Zoonoses |
description |
Golden hamsters were inoculated with Schistosoma haematobium cercariae to examine histological lesions at different time points over an 18 month period of infection. Hamsters were sacrificed 26 weeks and 82 weeks after inoculation. The parasite was found in the blood and in the liver of infected animals as was expected, but we found exclusively male worms, no female worms nor eggs. Interestingly we observed unexpected hepatic lesions induced by S. haematobium immature male worms alone in the golden hamster, characteristic of schistosome eggs. Samples from liver, kidneys, lungs, bladder and gastrointestinal tract were collected during necropsy to evaluate injuries induced by S. haematobium. Notably we observed hepatitis in the liver of infected hamsters, no lesions were found in other organs. We also found liver fibrosis in infected hamsters. This study provides further experimental evidence for the role that schistosome worms, and their derived antigens, may play in the pathology of the infection and modulation of liver chronic inflammation in the murine model of schistosomiasis. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-05 2010-05-01T00:00:00Z 2011-09-19T12:21:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/199 |
url |
http://hdl.handle.net/10400.18/199 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Virulence. 2010 May-Jun;1(3):123-9 2150-5594 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Landes Bioscience |
publisher.none.fl_str_mv |
Landes Bioscience |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132080211230720 |