Pentanucleotide repeat (TTTTA)n polymorphism in the 5' control region of the apoliprotein (A) gene and atherothrombotic serum lipoprotein (A) concentration, in a pediatric population
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/482 |
Resumo: | Lipoprotein (a) [Lp(a)] is a complex of apolipoprotein (a) [apo(a)] and low density lipoprotein, which is an independent major risk factor associated with atherothrombotic disease 1. Unlike other lipoproteins, interindividual differences in Lp(a) plasma concentration is almost entirely due to inheritance, most of them being attributed to sequence differences linked to the apo(a) locus.2,3,4 The primary structure of apo(a) encompasses a protease domain, a kringle V domain and a variable number of kringle IV repeats, which is homologous to the same domain in the plasminogen molecule and is thought to be responsible for the antifibrinolytic activity of Lp(a). The gene contains a pentanucleotide repeat (TTTTA)n polymorphism, 1.4 Kb upstream from the apo(a) gene reading frame. Eight different alleles have been detected to date, with the number of TTTTA repeats ranging from 5 to 12.5 This polymorphism, first described by Wade et al in 1993,6 has been suggested to be important in the control of apo(a) gene expression. Alleles containing more repeats were generally associated with lower plasma Lp(a) concentration. |
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Pentanucleotide repeat (TTTTA)n polymorphism in the 5' control region of the apoliprotein (A) gene and atherothrombotic serum lipoprotein (A) concentration, in a pediatric populationLipoproteinPolymorphisLipoprotein (a) [Lp(a)] is a complex of apolipoprotein (a) [apo(a)] and low density lipoprotein, which is an independent major risk factor associated with atherothrombotic disease 1. Unlike other lipoproteins, interindividual differences in Lp(a) plasma concentration is almost entirely due to inheritance, most of them being attributed to sequence differences linked to the apo(a) locus.2,3,4 The primary structure of apo(a) encompasses a protease domain, a kringle V domain and a variable number of kringle IV repeats, which is homologous to the same domain in the plasminogen molecule and is thought to be responsible for the antifibrinolytic activity of Lp(a). The gene contains a pentanucleotide repeat (TTTTA)n polymorphism, 1.4 Kb upstream from the apo(a) gene reading frame. Eight different alleles have been detected to date, with the number of TTTTA repeats ranging from 5 to 12.5 This polymorphism, first described by Wade et al in 1993,6 has been suggested to be important in the control of apo(a) gene expression. Alleles containing more repeats were generally associated with lower plasma Lp(a) concentration.European Hematology AssociationBiblioteca Digital do IPBFerreira, HelenaCosta, ElísioVieira, EmíliaLeão, AnabelaMagalhães, Rui Fernando MoreiraGomes, LourençoBarbot, JoséSantos, Rosário2008-02-15T11:11:33Z20032003-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/482engFerreira, Helena; Costa, Elísio; Vieira, Emília; Leão, Anabela; Magalhães, Rui; Gomes, Lourenço; Barbot, José; Santos, Rosário (2003) Pentanucleotide repeat (TTTTA)n polymorphism in the 5' control region of the apoliprotein (A) gene and atherothrombotic serum lipoprotein (A) concentration, in a pediatric population. Haematologica. ISSN 0390-6078. 88:3, p. 38-390390-6078info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:03:26Zoai:bibliotecadigital.ipb.pt:10198/482Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:54:16.819097Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Pentanucleotide repeat (TTTTA)n polymorphism in the 5' control region of the apoliprotein (A) gene and atherothrombotic serum lipoprotein (A) concentration, in a pediatric population |
title |
Pentanucleotide repeat (TTTTA)n polymorphism in the 5' control region of the apoliprotein (A) gene and atherothrombotic serum lipoprotein (A) concentration, in a pediatric population |
spellingShingle |
Pentanucleotide repeat (TTTTA)n polymorphism in the 5' control region of the apoliprotein (A) gene and atherothrombotic serum lipoprotein (A) concentration, in a pediatric population Ferreira, Helena Lipoprotein Polymorphis |
title_short |
Pentanucleotide repeat (TTTTA)n polymorphism in the 5' control region of the apoliprotein (A) gene and atherothrombotic serum lipoprotein (A) concentration, in a pediatric population |
title_full |
Pentanucleotide repeat (TTTTA)n polymorphism in the 5' control region of the apoliprotein (A) gene and atherothrombotic serum lipoprotein (A) concentration, in a pediatric population |
title_fullStr |
Pentanucleotide repeat (TTTTA)n polymorphism in the 5' control region of the apoliprotein (A) gene and atherothrombotic serum lipoprotein (A) concentration, in a pediatric population |
title_full_unstemmed |
Pentanucleotide repeat (TTTTA)n polymorphism in the 5' control region of the apoliprotein (A) gene and atherothrombotic serum lipoprotein (A) concentration, in a pediatric population |
title_sort |
Pentanucleotide repeat (TTTTA)n polymorphism in the 5' control region of the apoliprotein (A) gene and atherothrombotic serum lipoprotein (A) concentration, in a pediatric population |
author |
Ferreira, Helena |
author_facet |
Ferreira, Helena Costa, Elísio Vieira, Emília Leão, Anabela Magalhães, Rui Fernando Moreira Gomes, Lourenço Barbot, José Santos, Rosário |
author_role |
author |
author2 |
Costa, Elísio Vieira, Emília Leão, Anabela Magalhães, Rui Fernando Moreira Gomes, Lourenço Barbot, José Santos, Rosário |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Ferreira, Helena Costa, Elísio Vieira, Emília Leão, Anabela Magalhães, Rui Fernando Moreira Gomes, Lourenço Barbot, José Santos, Rosário |
dc.subject.por.fl_str_mv |
Lipoprotein Polymorphis |
topic |
Lipoprotein Polymorphis |
description |
Lipoprotein (a) [Lp(a)] is a complex of apolipoprotein (a) [apo(a)] and low density lipoprotein, which is an independent major risk factor associated with atherothrombotic disease 1. Unlike other lipoproteins, interindividual differences in Lp(a) plasma concentration is almost entirely due to inheritance, most of them being attributed to sequence differences linked to the apo(a) locus.2,3,4 The primary structure of apo(a) encompasses a protease domain, a kringle V domain and a variable number of kringle IV repeats, which is homologous to the same domain in the plasminogen molecule and is thought to be responsible for the antifibrinolytic activity of Lp(a). The gene contains a pentanucleotide repeat (TTTTA)n polymorphism, 1.4 Kb upstream from the apo(a) gene reading frame. Eight different alleles have been detected to date, with the number of TTTTA repeats ranging from 5 to 12.5 This polymorphism, first described by Wade et al in 1993,6 has been suggested to be important in the control of apo(a) gene expression. Alleles containing more repeats were generally associated with lower plasma Lp(a) concentration. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003 2003-01-01T00:00:00Z 2008-02-15T11:11:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/482 |
url |
http://hdl.handle.net/10198/482 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ferreira, Helena; Costa, Elísio; Vieira, Emília; Leão, Anabela; Magalhães, Rui; Gomes, Lourenço; Barbot, José; Santos, Rosário (2003) Pentanucleotide repeat (TTTTA)n polymorphism in the 5' control region of the apoliprotein (A) gene and atherothrombotic serum lipoprotein (A) concentration, in a pediatric population. Haematologica. ISSN 0390-6078. 88:3, p. 38-39 0390-6078 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
European Hematology Association |
publisher.none.fl_str_mv |
European Hematology Association |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135141007720448 |