Effects of acetylcholine on an animal mode of inflammation

Detalhes bibliográficos
Autor(a) principal: Silva-Herdade, Ana S.
Data de Publicação: 2013
Outros Autores: Saldanha, Carlota
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/10672
Resumo: © 2013 – IOS Press and the authors. All rights reserved
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spelling Effects of acetylcholine on an animal mode of inflammationInflammationAcetylcholineTNF-αVelnacrineRolling leukocytesIntravital microscopy© 2013 – IOS Press and the authors. All rights reservedAcetylcholinesterase (AChE) is found both on the membranes of neuronal and non-neuronal cells. In this study we performed intravenous administrations of velnacrine (VLN) and acetylcholine (ACh), respectively,AChE inhibitor and substrate, in an animal model of lipopolysaccharide (LPS)-induced inflammation in Wistar rats. Using intravital microscopy the number of rolling and adherent leukocytes in post-capillary venules was monitorized and blood samples were collected for TNF-α plasma concentrations determination. Our results showed that in presence of LPS, ACh has an anti-inflammatory effect, seen by a decrease in TNF-α plasma levels and maintains the number of rolling and adherent leukocytes. The presence of VLN before LPS almost blocked the LPS-induced rolling and TNF-α releasing. Thereby VLN seems to have, like ACh, an anti-inflammatory effect by diminishing TNF-α concentrations.IOS PressRepositório da Universidade de LisboaSilva-Herdade, Ana S.Saldanha, Carlota2014-03-04T16:06:46Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/10672engClinical Hemorheology and Microcirculation 53 (2013) 209–2161386-0291http://dx.doi.org/10.3233/CH-121646metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T15:56:19Zoai:repositorio.ul.pt:10451/10672Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:34:36.930503Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effects of acetylcholine on an animal mode of inflammation
title Effects of acetylcholine on an animal mode of inflammation
spellingShingle Effects of acetylcholine on an animal mode of inflammation
Silva-Herdade, Ana S.
Inflammation
Acetylcholine
TNF-α
Velnacrine
Rolling leukocytes
Intravital microscopy
title_short Effects of acetylcholine on an animal mode of inflammation
title_full Effects of acetylcholine on an animal mode of inflammation
title_fullStr Effects of acetylcholine on an animal mode of inflammation
title_full_unstemmed Effects of acetylcholine on an animal mode of inflammation
title_sort Effects of acetylcholine on an animal mode of inflammation
author Silva-Herdade, Ana S.
author_facet Silva-Herdade, Ana S.
Saldanha, Carlota
author_role author
author2 Saldanha, Carlota
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Silva-Herdade, Ana S.
Saldanha, Carlota
dc.subject.por.fl_str_mv Inflammation
Acetylcholine
TNF-α
Velnacrine
Rolling leukocytes
Intravital microscopy
topic Inflammation
Acetylcholine
TNF-α
Velnacrine
Rolling leukocytes
Intravital microscopy
description © 2013 – IOS Press and the authors. All rights reserved
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
2014-03-04T16:06:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/10672
url http://hdl.handle.net/10451/10672
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical Hemorheology and Microcirculation 53 (2013) 209–216
1386-0291
http://dx.doi.org/10.3233/CH-121646
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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