Optical microsystem for analysis of diffuse reflectance and fluorescence signals applied to early gastrointestinal Cancer Detection
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/37900 |
Resumo: | The detection of cancer at its earliest stage is crucial in order to increase the probability of a successful treatment. Optical techniques, specifically diffuse reflectance and fluorescence, may considerably improve the ability to detect pre-cancerous lesions. These techniques have high sensitivity to some biomarkers present on the tissues, providing morphological and biochemical information of normal and diseased tissue. The development of a chip sized spectroscopy microsystem, based on these techniques, will greatly improve the early diagnosis of gastrointestinal cancers. The main innovation is the detection of the spectroscopic signals using only few, but representative, spectral bands allowing for miniaturization. This paper presents the mathematical models, its validation and analysis for retrieving data of the measured spectroscopic signals. These models were applied to a set of phantoms clearly representative of gastrointestinal tissues, leading to a more accurate diagnostic by a pathologist. Moreover, it was demonstrated that the models can use the reconstructed spectroscopic signals based only on its extraction on those specific spectral bands. As a result, the viability of the spectroscopy microsystem implementation was proved. |
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Optical microsystem for analysis of diffuse reflectance and fluorescence signals applied to early gastrointestinal Cancer DetectionDiffuse reflectanceFluorescenceGastrointestinal cancerEarly detectionOptical microsystemEarly diagnosticMathematical modelsEngenharia e Tecnologia::Engenharia MédicaCiências Médicas::Outras Ciências MédicasScience & TechnologyThe detection of cancer at its earliest stage is crucial in order to increase the probability of a successful treatment. Optical techniques, specifically diffuse reflectance and fluorescence, may considerably improve the ability to detect pre-cancerous lesions. These techniques have high sensitivity to some biomarkers present on the tissues, providing morphological and biochemical information of normal and diseased tissue. The development of a chip sized spectroscopy microsystem, based on these techniques, will greatly improve the early diagnosis of gastrointestinal cancers. The main innovation is the detection of the spectroscopic signals using only few, but representative, spectral bands allowing for miniaturization. This paper presents the mathematical models, its validation and analysis for retrieving data of the measured spectroscopic signals. These models were applied to a set of phantoms clearly representative of gastrointestinal tissues, leading to a more accurate diagnostic by a pathologist. Moreover, it was demonstrated that the models can use the reconstructed spectroscopic signals based only on its extraction on those specific spectral bands. As a result, the viability of the spectroscopy microsystem implementation was proved.This work is funded by FEDER funds through the Eixo I do Programa Operacional Fatores de Competitividade (POFC) QREN, project references COMPETE: FCOMP-01-0124-FEDER-020241 and by FCT—Fundação para a Ciência e a Tecnologia, project reference PTDC/EBB-EBI/120334/2010. The authors also thanks to the PEst-C/FIS/UI0607/2013 for the use of spectroscopic equipment. S.P. thanks the FCT for the SFRH/BD/87605/2012 PhD grant.MDPIUniversidade do MinhoPimenta, SaraCastanheira, Elisabete M. S.Minas, Graça20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/37900engPimenta, S., Castanheira, E. M. S., & Minas, G. (2015). Optical Microsystem for Analysis of Diffuse Reflectance and Fluorescence Signals Applied to Early Gastrointestinal Cancer Detection. Sensors, 15(2), 3138-3153. doi: 10.3390/s1502031381424-822010.3390/s15020313825647742www.mdpi.com/journal/sensorsinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:51:02Zoai:repositorium.sdum.uminho.pt:1822/37900Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:49:48.715743Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Optical microsystem for analysis of diffuse reflectance and fluorescence signals applied to early gastrointestinal Cancer Detection |
title |
Optical microsystem for analysis of diffuse reflectance and fluorescence signals applied to early gastrointestinal Cancer Detection |
spellingShingle |
Optical microsystem for analysis of diffuse reflectance and fluorescence signals applied to early gastrointestinal Cancer Detection Pimenta, Sara Diffuse reflectance Fluorescence Gastrointestinal cancer Early detection Optical microsystem Early diagnostic Mathematical models Engenharia e Tecnologia::Engenharia Médica Ciências Médicas::Outras Ciências Médicas Science & Technology |
title_short |
Optical microsystem for analysis of diffuse reflectance and fluorescence signals applied to early gastrointestinal Cancer Detection |
title_full |
Optical microsystem for analysis of diffuse reflectance and fluorescence signals applied to early gastrointestinal Cancer Detection |
title_fullStr |
Optical microsystem for analysis of diffuse reflectance and fluorescence signals applied to early gastrointestinal Cancer Detection |
title_full_unstemmed |
Optical microsystem for analysis of diffuse reflectance and fluorescence signals applied to early gastrointestinal Cancer Detection |
title_sort |
Optical microsystem for analysis of diffuse reflectance and fluorescence signals applied to early gastrointestinal Cancer Detection |
author |
Pimenta, Sara |
author_facet |
Pimenta, Sara Castanheira, Elisabete M. S. Minas, Graça |
author_role |
author |
author2 |
Castanheira, Elisabete M. S. Minas, Graça |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Pimenta, Sara Castanheira, Elisabete M. S. Minas, Graça |
dc.subject.por.fl_str_mv |
Diffuse reflectance Fluorescence Gastrointestinal cancer Early detection Optical microsystem Early diagnostic Mathematical models Engenharia e Tecnologia::Engenharia Médica Ciências Médicas::Outras Ciências Médicas Science & Technology |
topic |
Diffuse reflectance Fluorescence Gastrointestinal cancer Early detection Optical microsystem Early diagnostic Mathematical models Engenharia e Tecnologia::Engenharia Médica Ciências Médicas::Outras Ciências Médicas Science & Technology |
description |
The detection of cancer at its earliest stage is crucial in order to increase the probability of a successful treatment. Optical techniques, specifically diffuse reflectance and fluorescence, may considerably improve the ability to detect pre-cancerous lesions. These techniques have high sensitivity to some biomarkers present on the tissues, providing morphological and biochemical information of normal and diseased tissue. The development of a chip sized spectroscopy microsystem, based on these techniques, will greatly improve the early diagnosis of gastrointestinal cancers. The main innovation is the detection of the spectroscopic signals using only few, but representative, spectral bands allowing for miniaturization. This paper presents the mathematical models, its validation and analysis for retrieving data of the measured spectroscopic signals. These models were applied to a set of phantoms clearly representative of gastrointestinal tissues, leading to a more accurate diagnostic by a pathologist. Moreover, it was demonstrated that the models can use the reconstructed spectroscopic signals based only on its extraction on those specific spectral bands. As a result, the viability of the spectroscopy microsystem implementation was proved. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/37900 |
url |
http://hdl.handle.net/1822/37900 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pimenta, S., Castanheira, E. M. S., & Minas, G. (2015). Optical Microsystem for Analysis of Diffuse Reflectance and Fluorescence Signals Applied to Early Gastrointestinal Cancer Detection. Sensors, 15(2), 3138-3153. doi: 10.3390/s150203138 1424-8220 10.3390/s150203138 25647742 www.mdpi.com/journal/sensors |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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