Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100M
Autor(a) principal: | |
---|---|
Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/8991 https://doi.org/10.1080/10837450600561349 |
Resumo: | The influence of cellulose ether derivatives on ibuprofen release from matrix tablets was investigated. Raman spectroscopy and differential scanning calorimetry (DSC) experiments were used, in order to examine the compatibility between the matrix components: both excipients and ibuprofen. While both the DSC and Raman results did not detect any incompatibilities, DSC revealed the existence of some drug:excipient interactions, reflected by variations in the hydration/dehydration processes. Formulations containing mixtures of polymers with both low and high viscosity grades—methylcellulose (MC25) or hydroxypropylcellulose (HPC), and hydroxypropylmethylcellulose (HPMC K100M), respectively—were prepared by a direct compression method (using 20, 25, and 30% of either MC25 or HPC). The tablets were evaluated for their drug content, weight uniformity, hardness, thickness, tensile strength, friability, porosity, surface area, and volume. Parameters such as the mean dissolution time (MDT) and the dissolution efficiency (DE) were calculated in all cases. The solid formulations presently studied demonstrated a predominantly Fickian diffusion release mechanism. |
id |
RCAP_86b68c39e4e586994596429b100ed057 |
---|---|
oai_identifier_str |
oai:estudogeral.uc.pt:10316/8991 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100MThe influence of cellulose ether derivatives on ibuprofen release from matrix tablets was investigated. Raman spectroscopy and differential scanning calorimetry (DSC) experiments were used, in order to examine the compatibility between the matrix components: both excipients and ibuprofen. While both the DSC and Raman results did not detect any incompatibilities, DSC revealed the existence of some drug:excipient interactions, reflected by variations in the hydration/dehydration processes. Formulations containing mixtures of polymers with both low and high viscosity grades—methylcellulose (MC25) or hydroxypropylcellulose (HPC), and hydroxypropylmethylcellulose (HPMC K100M), respectively—were prepared by a direct compression method (using 20, 25, and 30% of either MC25 or HPC). The tablets were evaluated for their drug content, weight uniformity, hardness, thickness, tensile strength, friability, porosity, surface area, and volume. Parameters such as the mean dissolution time (MDT) and the dissolution efficiency (DE) were calculated in all cases. The solid formulations presently studied demonstrated a predominantly Fickian diffusion release mechanism.http://www.informaworld.com/10.1080/108374506005613492006info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/8991http://hdl.handle.net/10316/8991https://doi.org/10.1080/10837450600561349engPharmaceutical Development and Technology - Informa Healthcare. 11:2 (2006) 213-228Vueba, M. L.Carvalho, L. A. E. Batista deVeiga, F.Sousa, J. J.Pina, M. E.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T03:13:45Zoai:estudogeral.uc.pt:10316/8991Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:47:25.041229Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100M |
title |
Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100M |
spellingShingle |
Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100M Vueba, M. L. |
title_short |
Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100M |
title_full |
Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100M |
title_fullStr |
Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100M |
title_full_unstemmed |
Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100M |
title_sort |
Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100M |
author |
Vueba, M. L. |
author_facet |
Vueba, M. L. Carvalho, L. A. E. Batista de Veiga, F. Sousa, J. J. Pina, M. E. |
author_role |
author |
author2 |
Carvalho, L. A. E. Batista de Veiga, F. Sousa, J. J. Pina, M. E. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Vueba, M. L. Carvalho, L. A. E. Batista de Veiga, F. Sousa, J. J. Pina, M. E. |
description |
The influence of cellulose ether derivatives on ibuprofen release from matrix tablets was investigated. Raman spectroscopy and differential scanning calorimetry (DSC) experiments were used, in order to examine the compatibility between the matrix components: both excipients and ibuprofen. While both the DSC and Raman results did not detect any incompatibilities, DSC revealed the existence of some drug:excipient interactions, reflected by variations in the hydration/dehydration processes. Formulations containing mixtures of polymers with both low and high viscosity grades—methylcellulose (MC25) or hydroxypropylcellulose (HPC), and hydroxypropylmethylcellulose (HPMC K100M), respectively—were prepared by a direct compression method (using 20, 25, and 30% of either MC25 or HPC). The tablets were evaluated for their drug content, weight uniformity, hardness, thickness, tensile strength, friability, porosity, surface area, and volume. Parameters such as the mean dissolution time (MDT) and the dissolution efficiency (DE) were calculated in all cases. The solid formulations presently studied demonstrated a predominantly Fickian diffusion release mechanism. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/8991 http://hdl.handle.net/10316/8991 https://doi.org/10.1080/10837450600561349 |
url |
http://hdl.handle.net/10316/8991 https://doi.org/10.1080/10837450600561349 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmaceutical Development and Technology - Informa Healthcare. 11:2 (2006) 213-228 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799133751190487040 |