Angiogenesis as a Therapeutic Target in Endometriosis
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5244 |
Resumo: | Introduction: Angiogenesis is a key factor for the successful establishment and growth of endometriotic lesions.Material and Methods: We performed a literature search in PubMed and reviewed the most pertinent studies published until January 2014 and focused on the endometriosis-associated angiogenesis and/or anti-angiogenic strategies for the treatment of this gynecological disorder.Results: The present review provides a concise summary of the known molecular mechanisms that promote vascularization of endometriotic lesions and may serve as potential therapeutic targets. We also present a systematic overview of the inclusive and exclusive anti-angiogenic agents that have been already studied in cell cultures, animal models and/or endometriosis patients.Discussion and Conclusion: The integration of anti-angiogenic approaches in the multimodal management strategies for endometriosis patients will be conditioned by the outcomes of future assessments regarding the effectiveness of such treatments, the risk of drug resistance development and the incidence of unacceptable side effects.Keywords: Angiogenesis Inhibitors/therapeutic use; Endometriosis/drug therapy. |
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Angiogenesis as a Therapeutic Target in EndometriosisAngiogénese como um Alvo Terapêutico para a EndometrioseIntroduction: Angiogenesis is a key factor for the successful establishment and growth of endometriotic lesions.Material and Methods: We performed a literature search in PubMed and reviewed the most pertinent studies published until January 2014 and focused on the endometriosis-associated angiogenesis and/or anti-angiogenic strategies for the treatment of this gynecological disorder.Results: The present review provides a concise summary of the known molecular mechanisms that promote vascularization of endometriotic lesions and may serve as potential therapeutic targets. We also present a systematic overview of the inclusive and exclusive anti-angiogenic agents that have been already studied in cell cultures, animal models and/or endometriosis patients.Discussion and Conclusion: The integration of anti-angiogenic approaches in the multimodal management strategies for endometriosis patients will be conditioned by the outcomes of future assessments regarding the effectiveness of such treatments, the risk of drug resistance development and the incidence of unacceptable side effects.Keywords: Angiogenesis Inhibitors/therapeutic use; Endometriosis/drug therapy.Introdução: A angiogénese é um factor determinante no estabelecimento e desenvolvimento das lesões de endometriose.Material e Métodos: Foram revistos os artigos indexados na PubMed e incluídos os estudos mais relevantes, publicados até Janeiro de 2014, sobre a angiogénese nas lesões de endometriose e/ou estratégias anti-angiogénicas para o tratamento desta doença ginecológica.Resultados: O presente artigo fornece um resumo conciso dos mecanismos moleculares conhecidos que promovem a vascularização das lesões de endometriose, podendo servir como alvos terapêuticos potenciais. Apresenta-se também uma revisão sistemática dos agentes anti-angiogénicos, inclusivos e exclusivos, que já foram avaliados em culturas de células, modelos animais e/ou doentes com endometriose.Discussão e Conclusão: A integração das estratégias anti- angiogénicas na terapêutica multimodal de endometriose será condicionada pelos resultados de avaliações futuras da verdadeira eficácia desses tratamentos, do risco de desenvolvimento de resistência aos medicamentos e da incidência de efeitos colaterais inaceitáveis.Palavras-chave: Inibidores da Angiogénese/uso terapêutico; Endometriose/terapêutica.Ordem dos Médicos2014-08-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/postscriptapplication/postscripthttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5244oai:ojs.www.actamedicaportuguesa.com:article/5244Acta Médica Portuguesa; Vol. 27 No. 4 (2014): July-August; 489-497Acta Médica Portuguesa; Vol. 27 N.º 4 (2014): Julho-Agosto; 489-4971646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5244https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5244/4020https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5244/7120https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5244/7121https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5244/7122Djokovic, DusanCalhaz-Jorge, Carlosinfo:eu-repo/semantics/openAccess2022-12-20T11:04:16Zoai:ojs.www.actamedicaportuguesa.com:article/5244Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:03.252670Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Angiogenesis as a Therapeutic Target in Endometriosis Angiogénese como um Alvo Terapêutico para a Endometriose |
title |
Angiogenesis as a Therapeutic Target in Endometriosis |
spellingShingle |
Angiogenesis as a Therapeutic Target in Endometriosis Djokovic, Dusan |
title_short |
Angiogenesis as a Therapeutic Target in Endometriosis |
title_full |
Angiogenesis as a Therapeutic Target in Endometriosis |
title_fullStr |
Angiogenesis as a Therapeutic Target in Endometriosis |
title_full_unstemmed |
Angiogenesis as a Therapeutic Target in Endometriosis |
title_sort |
Angiogenesis as a Therapeutic Target in Endometriosis |
author |
Djokovic, Dusan |
author_facet |
Djokovic, Dusan Calhaz-Jorge, Carlos |
author_role |
author |
author2 |
Calhaz-Jorge, Carlos |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Djokovic, Dusan Calhaz-Jorge, Carlos |
description |
Introduction: Angiogenesis is a key factor for the successful establishment and growth of endometriotic lesions.Material and Methods: We performed a literature search in PubMed and reviewed the most pertinent studies published until January 2014 and focused on the endometriosis-associated angiogenesis and/or anti-angiogenic strategies for the treatment of this gynecological disorder.Results: The present review provides a concise summary of the known molecular mechanisms that promote vascularization of endometriotic lesions and may serve as potential therapeutic targets. We also present a systematic overview of the inclusive and exclusive anti-angiogenic agents that have been already studied in cell cultures, animal models and/or endometriosis patients.Discussion and Conclusion: The integration of anti-angiogenic approaches in the multimodal management strategies for endometriosis patients will be conditioned by the outcomes of future assessments regarding the effectiveness of such treatments, the risk of drug resistance development and the incidence of unacceptable side effects.Keywords: Angiogenesis Inhibitors/therapeutic use; Endometriosis/drug therapy. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5244 oai:ojs.www.actamedicaportuguesa.com:article/5244 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5244 |
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oai:ojs.www.actamedicaportuguesa.com:article/5244 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5244 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5244/4020 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5244/7120 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5244/7121 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5244/7122 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf application/pdf application/postscript application/postscript |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 27 No. 4 (2014): July-August; 489-497 Acta Médica Portuguesa; Vol. 27 N.º 4 (2014): Julho-Agosto; 489-497 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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