Exposure to ambient particulate matter increases blood count parameters with potential to mediate a cardiovascular event
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/126135 |
Resumo: | Variations in blood count parameters are potential mechanisms involved in the occurrence of cardiovascular events caused by particulate matter (PM) exposure. This study aims to estimate the effect of PM10 exposure on blood count parameters with potential to mediate a cardiovascular event. We used data from 2211 participants of the 1st Portuguese Health Examination Survey (INSEF, 2015) with available information on blood count parameters and living within a 30-km radius of at least one air quality monitoring station with available PM10 measurements. Generalised linear models were used to assess both short (3 days) and long-term effects (1 year) of PM10 exposure on blood count parameters. Both short and long-term PM10 effects on blood count parameters were found, with males and females affected in a different way. In the short-term scenario, we found a 2.76% (95% CI: 0.65–4.87) increase in white blood cells among females per each 10μg/m3 PM10 increment. Additionally, there was a 2.96% (95% CI: 0.80–5.12) increase in red cell distribution width (RDW), per each 10μg/m3 PM10 increment, among males, when considering the long-term scenario. In conclusion, we detected some sex-differential associations regarding the short and long-term effect of PM10 exposure on blood count parameters with potential to mediate a cardiovascular event, namely on the RDW parameter, that were never been described. It is uncertain whether changes in blood count parameters due to PM10 exposure constitute an adverse health outcome or it reflects only a normal immunity response. However, due to its potential to trigger cardiovascular events, it is essential to reduce PM10 levels exposure to protect the population’s cardiovascular health. |
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Exposure to ambient particulate matter increases blood count parameters with potential to mediate a cardiovascular eventresults from a population-based study in PortugalBlood countsINSEF 2015LeucocytesParticulate matterPlateletsRDWPollutionAtmospheric ScienceManagement, Monitoring, Policy and LawHealth, Toxicology and MutagenesisVariations in blood count parameters are potential mechanisms involved in the occurrence of cardiovascular events caused by particulate matter (PM) exposure. This study aims to estimate the effect of PM10 exposure on blood count parameters with potential to mediate a cardiovascular event. We used data from 2211 participants of the 1st Portuguese Health Examination Survey (INSEF, 2015) with available information on blood count parameters and living within a 30-km radius of at least one air quality monitoring station with available PM10 measurements. Generalised linear models were used to assess both short (3 days) and long-term effects (1 year) of PM10 exposure on blood count parameters. Both short and long-term PM10 effects on blood count parameters were found, with males and females affected in a different way. In the short-term scenario, we found a 2.76% (95% CI: 0.65–4.87) increase in white blood cells among females per each 10μg/m3 PM10 increment. Additionally, there was a 2.96% (95% CI: 0.80–5.12) increase in red cell distribution width (RDW), per each 10μg/m3 PM10 increment, among males, when considering the long-term scenario. In conclusion, we detected some sex-differential associations regarding the short and long-term effect of PM10 exposure on blood count parameters with potential to mediate a cardiovascular event, namely on the RDW parameter, that were never been described. It is uncertain whether changes in blood count parameters due to PM10 exposure constitute an adverse health outcome or it reflects only a normal immunity response. However, due to its potential to trigger cardiovascular events, it is essential to reduce PM10 levels exposure to protect the population’s cardiovascular health.Centro de Investigação em Saúde Pública (CISP/PHRC)Information Management Research Center (MagIC) - NOVA Information Management SchoolNOVA Information Management School (NOVA IMS)Escola Nacional de Saúde Pública (ENSP)RUNGaio, VâniaRoquette, RitaMonteiro, AlexandraFerreira, JoanaRafael, SandraDias, Carlos MatiasNunes, Baltazar2021-10-14T23:20:54Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/126135eng1873-9318PURE: 29060757https://doi.org/10.1007/s11869-021-01007-9info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:06:47Zoai:run.unl.pt:10362/126135Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:45:51.517687Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Exposure to ambient particulate matter increases blood count parameters with potential to mediate a cardiovascular event results from a population-based study in Portugal |
title |
Exposure to ambient particulate matter increases blood count parameters with potential to mediate a cardiovascular event |
spellingShingle |
Exposure to ambient particulate matter increases blood count parameters with potential to mediate a cardiovascular event Gaio, Vânia Blood counts INSEF 2015 Leucocytes Particulate matter Platelets RDW Pollution Atmospheric Science Management, Monitoring, Policy and Law Health, Toxicology and Mutagenesis |
title_short |
Exposure to ambient particulate matter increases blood count parameters with potential to mediate a cardiovascular event |
title_full |
Exposure to ambient particulate matter increases blood count parameters with potential to mediate a cardiovascular event |
title_fullStr |
Exposure to ambient particulate matter increases blood count parameters with potential to mediate a cardiovascular event |
title_full_unstemmed |
Exposure to ambient particulate matter increases blood count parameters with potential to mediate a cardiovascular event |
title_sort |
Exposure to ambient particulate matter increases blood count parameters with potential to mediate a cardiovascular event |
author |
Gaio, Vânia |
author_facet |
Gaio, Vânia Roquette, Rita Monteiro, Alexandra Ferreira, Joana Rafael, Sandra Dias, Carlos Matias Nunes, Baltazar |
author_role |
author |
author2 |
Roquette, Rita Monteiro, Alexandra Ferreira, Joana Rafael, Sandra Dias, Carlos Matias Nunes, Baltazar |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Centro de Investigação em Saúde Pública (CISP/PHRC) Information Management Research Center (MagIC) - NOVA Information Management School NOVA Information Management School (NOVA IMS) Escola Nacional de Saúde Pública (ENSP) RUN |
dc.contributor.author.fl_str_mv |
Gaio, Vânia Roquette, Rita Monteiro, Alexandra Ferreira, Joana Rafael, Sandra Dias, Carlos Matias Nunes, Baltazar |
dc.subject.por.fl_str_mv |
Blood counts INSEF 2015 Leucocytes Particulate matter Platelets RDW Pollution Atmospheric Science Management, Monitoring, Policy and Law Health, Toxicology and Mutagenesis |
topic |
Blood counts INSEF 2015 Leucocytes Particulate matter Platelets RDW Pollution Atmospheric Science Management, Monitoring, Policy and Law Health, Toxicology and Mutagenesis |
description |
Variations in blood count parameters are potential mechanisms involved in the occurrence of cardiovascular events caused by particulate matter (PM) exposure. This study aims to estimate the effect of PM10 exposure on blood count parameters with potential to mediate a cardiovascular event. We used data from 2211 participants of the 1st Portuguese Health Examination Survey (INSEF, 2015) with available information on blood count parameters and living within a 30-km radius of at least one air quality monitoring station with available PM10 measurements. Generalised linear models were used to assess both short (3 days) and long-term effects (1 year) of PM10 exposure on blood count parameters. Both short and long-term PM10 effects on blood count parameters were found, with males and females affected in a different way. In the short-term scenario, we found a 2.76% (95% CI: 0.65–4.87) increase in white blood cells among females per each 10μg/m3 PM10 increment. Additionally, there was a 2.96% (95% CI: 0.80–5.12) increase in red cell distribution width (RDW), per each 10μg/m3 PM10 increment, among males, when considering the long-term scenario. In conclusion, we detected some sex-differential associations regarding the short and long-term effect of PM10 exposure on blood count parameters with potential to mediate a cardiovascular event, namely on the RDW parameter, that were never been described. It is uncertain whether changes in blood count parameters due to PM10 exposure constitute an adverse health outcome or it reflects only a normal immunity response. However, due to its potential to trigger cardiovascular events, it is essential to reduce PM10 levels exposure to protect the population’s cardiovascular health. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-14T23:20:54Z 2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/126135 |
url |
http://hdl.handle.net/10362/126135 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1873-9318 PURE: 29060757 https://doi.org/10.1007/s11869-021-01007-9 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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