In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.1128/AAC.00298-15 |
Resumo: | PMID: 26014947 WOS:000362952000090 |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanesPharmacologyInfectious DiseasesPharmacology (medical)SDG 3 - Good Health and Well-beingPMID: 26014947 WOS:000362952000090Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and intramacrophage amastigote forms of Leishmania infantum. The trioxolanes LC50 and LC95 presented the best activity and safety profiles, showing potential for further studies in the context of leishmanial therapy. Our results indicate that the compounds tested exhibit peroxide-dependent activity.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)Vector borne diseases and pathogens (VBD)RUNCortes, SofiaAlbuquerque, AndreiaCabral, Lília I LLopes, LilianaCampino, LeneaCristiano, Maria L S2018-05-14T22:01:36Z2015-08-012015-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article4application/pdfhttps://doi.org/10.1128/AAC.00298-15eng0066-4804PURE: 1645540http://www.scopus.com/inward/record.url?scp=84940196134&partnerID=8YFLogxKhttps://doi.org/10.1128/AAC.00298-15info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:20:28Zoai:run.unl.pt:10362/36927Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:30:42.203787Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes |
title |
In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes |
spellingShingle |
In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes Cortes, Sofia Pharmacology Infectious Diseases Pharmacology (medical) SDG 3 - Good Health and Well-being |
title_short |
In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes |
title_full |
In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes |
title_fullStr |
In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes |
title_full_unstemmed |
In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes |
title_sort |
In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes |
author |
Cortes, Sofia |
author_facet |
Cortes, Sofia Albuquerque, Andreia Cabral, Lília I L Lopes, Liliana Campino, Lenea Cristiano, Maria L S |
author_role |
author |
author2 |
Albuquerque, Andreia Cabral, Lília I L Lopes, Liliana Campino, Lenea Cristiano, Maria L S |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) Vector borne diseases and pathogens (VBD) RUN |
dc.contributor.author.fl_str_mv |
Cortes, Sofia Albuquerque, Andreia Cabral, Lília I L Lopes, Liliana Campino, Lenea Cristiano, Maria L S |
dc.subject.por.fl_str_mv |
Pharmacology Infectious Diseases Pharmacology (medical) SDG 3 - Good Health and Well-being |
topic |
Pharmacology Infectious Diseases Pharmacology (medical) SDG 3 - Good Health and Well-being |
description |
PMID: 26014947 WOS:000362952000090 |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-01 2015-08-01T00:00:00Z 2018-05-14T22:01:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1128/AAC.00298-15 |
url |
https://doi.org/10.1128/AAC.00298-15 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0066-4804 PURE: 1645540 http://www.scopus.com/inward/record.url?scp=84940196134&partnerID=8YFLogxK https://doi.org/10.1128/AAC.00298-15 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
4 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799137931343953920 |