On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models

Detalhes bibliográficos
Autor(a) principal: Ventura, Célia
Data de Publicação: 2020
Outros Autores: Pinto, Fátima, Lourenço, Ana Filipa, Ferreira, Paulo J.T., Louro, Henriqueta, Silva, Maria João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/7361
Resumo: Review
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spelling On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular modelsCellulose NanofibrilsCellulose NanocrystalsEnvironmental GenotoxicityNanotoxicologyImmunotoxicityNanocellulose ProductionGenotoxicidade AmbientalReviewThe need for reaching environmental sustainability encourages research on new cellulosebased materials for a broad range of applications across many sectors of industry. Cellulosic nanomaterials obtained from different sources and with different functionalization are being developed with the purpose of its use in many applications, in pure and composite forms, from consumer products to pharmaceutics and healthcare products. Based on previous knowledge about the possible adverse health effects of other nanomaterials with high aspect ratio and biopersistency in body fluids, e.g., carbon nanotubes, it is expected that the nanometric size of nanocellulose will increase its toxicity as compared to that of bulk cellulose. Several toxicological studies have been performed, in vitro or in vivo, with the aim of predicting the health effects caused by exposure to nanocellulose. Ultimately, their goal is to reduce the risk to humans associated with unintentional environmental or occupational exposure, and the design of safe nanocellulose materials to be used, e.g., as carriers for drug delivery or other biomedical applications, as in wound dressing materials. This review intends to identify the toxicological effects that are elicited by nanocelluloses produced through a topdown approach from vegetal biomass, namely, cellulose nanocrystals and nanofibrils, and relate them with the physicochemical characteristics of nanocellulose. For this purpose, the article provides: (i) a brief review of the types and applications of cellulose nanomaterials; (ii) a comprehensive review of the literature reporting their biological impact, alongside to their specific physicochemical characteristics, in order to draw conclusions about their effects on human health.The authors acknowledge CYTED network NANOCELIA (Transferencia Tecnolo´gica sobre aplicaciones de nanocelulosa en iberoame´rica). The work was funded by FCT/MCTES, Project ToxApp4NanoCELFI (PTDC/ SAU-PUB/32587/2017) through national funds (PIDDAC), and co-funded by ToxOmics – Center for Toxicogenomics and Human Health (UID/BIM/00009/2013). Sara Teixeira is acknowledged for the binucleated cells photo.SpringerRepositório Científico do Instituto Nacional de SaúdeVentura, CéliaPinto, FátimaLourenço, Ana FilipaFerreira, Paulo J.T.Louro, HenriquetaSilva, Maria João2021-03-08T15:13:38Z2020-05-042020-05-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7361eng Cellulose. 2020 May 4;27:5509-44.doi: 10.1007/s10570-020-03176-90969-023910.1007/s10570-020-03176-9info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:56Zoai:repositorio.insa.pt:10400.18/7361Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:58.413558Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
title On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
spellingShingle On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
Ventura, Célia
Cellulose Nanofibrils
Cellulose Nanocrystals
Environmental Genotoxicity
Nanotoxicology
Immunotoxicity
Nanocellulose Production
Genotoxicidade Ambiental
title_short On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
title_full On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
title_fullStr On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
title_full_unstemmed On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
title_sort On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models
author Ventura, Célia
author_facet Ventura, Célia
Pinto, Fátima
Lourenço, Ana Filipa
Ferreira, Paulo J.T.
Louro, Henriqueta
Silva, Maria João
author_role author
author2 Pinto, Fátima
Lourenço, Ana Filipa
Ferreira, Paulo J.T.
Louro, Henriqueta
Silva, Maria João
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Ventura, Célia
Pinto, Fátima
Lourenço, Ana Filipa
Ferreira, Paulo J.T.
Louro, Henriqueta
Silva, Maria João
dc.subject.por.fl_str_mv Cellulose Nanofibrils
Cellulose Nanocrystals
Environmental Genotoxicity
Nanotoxicology
Immunotoxicity
Nanocellulose Production
Genotoxicidade Ambiental
topic Cellulose Nanofibrils
Cellulose Nanocrystals
Environmental Genotoxicity
Nanotoxicology
Immunotoxicity
Nanocellulose Production
Genotoxicidade Ambiental
description Review
publishDate 2020
dc.date.none.fl_str_mv 2020-05-04
2020-05-04T00:00:00Z
2021-03-08T15:13:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/7361
url http://hdl.handle.net/10400.18/7361
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv  Cellulose. 2020 May 4;27:5509-44.doi: 10.1007/s10570-020-03176-9
0969-0239
10.1007/s10570-020-03176-9
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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