Autonomic Function Evaluation in an Intermittent Lead Exposure Animal Model
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.34629/ipl.isel.i-ETC.28 |
Resumo: | Lead (Pb) is a toxic metal, which widespread use has resulted in environmental contamination, human exposure and significant public health problems. The autonomic nervous system, being a homeostatic controller, is impaired in acute and chronic lead exposure. In fact, sympathoexcitation associated to hypertension and tachypnea has been described together with baroreflex and chemoreflex dysfunction. However, up to date, no studies described the autonomic effects of an intermittent low-level lead exposure. In the present work, we addressed in vivo, autonomic behaviour in rats under chronic Pb exposure (control) and in rats under intermittent Pb exposure. For that, arterial blood pressure (BP) and ECG were recorded in 28 weeks old animal and low frequencies (LF) and high frequencies (HF) were determined (to estimate sympathetic and parasympathetic activities) using FisioSinal software with Wavelet module. Preliminary results: Rats intermittently exposed to lead showed a significant decrease in systolic BP (126 ± 4 vs 144 ± 3 mmHg) with no significant changes in LF, HF and LF/HF bands (1.5 ± 0.3 vs 1.7 ± 0.5 mmHg2, 1.9 ± 0.7 vs 2.8 ± 1.2 bpm2 and 1.2 ± 0.4 vs 1.1 ± 0.3 mmHg2/bpm2, respectively) when compared to chronically Pb exposed rats. Our data suggests that the autonomic dysfunction induced by lead exposure is similar in a chronic and intermittent Pb exposure. Nevertheless, it seems that an intermittent exposure was no effect on systolic BP values.The present study brings new insights on the environmental factors that influence autonomic and cardiovascular systems during development, which can help apprise public policy strategies to prevent and control the adverse effects of Pb toxicity. |
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Autonomic Function Evaluation in an Intermittent Lead Exposure Animal ModelToxicology, Medicine, PhysiologyLead toxicity, autonomic activity, Fisiosinal, Wavelet analysis, Heart Rate VariabilityLead (Pb) is a toxic metal, which widespread use has resulted in environmental contamination, human exposure and significant public health problems. The autonomic nervous system, being a homeostatic controller, is impaired in acute and chronic lead exposure. In fact, sympathoexcitation associated to hypertension and tachypnea has been described together with baroreflex and chemoreflex dysfunction. However, up to date, no studies described the autonomic effects of an intermittent low-level lead exposure. In the present work, we addressed in vivo, autonomic behaviour in rats under chronic Pb exposure (control) and in rats under intermittent Pb exposure. For that, arterial blood pressure (BP) and ECG were recorded in 28 weeks old animal and low frequencies (LF) and high frequencies (HF) were determined (to estimate sympathetic and parasympathetic activities) using FisioSinal software with Wavelet module. Preliminary results: Rats intermittently exposed to lead showed a significant decrease in systolic BP (126 ± 4 vs 144 ± 3 mmHg) with no significant changes in LF, HF and LF/HF bands (1.5 ± 0.3 vs 1.7 ± 0.5 mmHg2, 1.9 ± 0.7 vs 2.8 ± 1.2 bpm2 and 1.2 ± 0.4 vs 1.1 ± 0.3 mmHg2/bpm2, respectively) when compared to chronically Pb exposed rats. Our data suggests that the autonomic dysfunction induced by lead exposure is similar in a chronic and intermittent Pb exposure. Nevertheless, it seems that an intermittent exposure was no effect on systolic BP values.The present study brings new insights on the environmental factors that influence autonomic and cardiovascular systems during development, which can help apprise public policy strategies to prevent and control the adverse effects of Pb toxicity.ISEL - High Institute of Engineering of Lisbon2018-01-22T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.34629/ipl.isel.i-ETC.28oai:i-ETC.journals.isel.pt:article/28i-ETC : ISEL Academic Journal of Electronics Telecommunications and Computers; Vol 3, No 1 (2017): The CETC2016 Issue (A); ID-11i-ETC : ISEL Academic Journal of Electronics Telecommunications and Computers; Vol 3, No 1 (2017): The CETC2016 Issue (A); ID-112182-4010reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://journals.isel.pt/index.php/i-ETC/article/view/28https://doi.org/10.34629/ipl.isel.i-ETC.28http://journals.isel.pt/index.php/i-ETC/article/view/28/37Copyright (c) 2018 Liana Shvachiy, Vera Geraldes, Mafalda Carvalho, Isabel Rochahttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessShvachiy, LianaGeraldes, VeraCarvalho, MafaldaRocha, Isabel2022-09-20T15:26:06Zoai:i-ETC.journals.isel.pt:article/28Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:51:11.678891Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Autonomic Function Evaluation in an Intermittent Lead Exposure Animal Model |
title |
Autonomic Function Evaluation in an Intermittent Lead Exposure Animal Model |
spellingShingle |
Autonomic Function Evaluation in an Intermittent Lead Exposure Animal Model Shvachiy, Liana Toxicology, Medicine, Physiology Lead toxicity, autonomic activity, Fisiosinal, Wavelet analysis, Heart Rate Variability |
title_short |
Autonomic Function Evaluation in an Intermittent Lead Exposure Animal Model |
title_full |
Autonomic Function Evaluation in an Intermittent Lead Exposure Animal Model |
title_fullStr |
Autonomic Function Evaluation in an Intermittent Lead Exposure Animal Model |
title_full_unstemmed |
Autonomic Function Evaluation in an Intermittent Lead Exposure Animal Model |
title_sort |
Autonomic Function Evaluation in an Intermittent Lead Exposure Animal Model |
author |
Shvachiy, Liana |
author_facet |
Shvachiy, Liana Geraldes, Vera Carvalho, Mafalda Rocha, Isabel |
author_role |
author |
author2 |
Geraldes, Vera Carvalho, Mafalda Rocha, Isabel |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Shvachiy, Liana Geraldes, Vera Carvalho, Mafalda Rocha, Isabel |
dc.subject.por.fl_str_mv |
Toxicology, Medicine, Physiology Lead toxicity, autonomic activity, Fisiosinal, Wavelet analysis, Heart Rate Variability |
topic |
Toxicology, Medicine, Physiology Lead toxicity, autonomic activity, Fisiosinal, Wavelet analysis, Heart Rate Variability |
description |
Lead (Pb) is a toxic metal, which widespread use has resulted in environmental contamination, human exposure and significant public health problems. The autonomic nervous system, being a homeostatic controller, is impaired in acute and chronic lead exposure. In fact, sympathoexcitation associated to hypertension and tachypnea has been described together with baroreflex and chemoreflex dysfunction. However, up to date, no studies described the autonomic effects of an intermittent low-level lead exposure. In the present work, we addressed in vivo, autonomic behaviour in rats under chronic Pb exposure (control) and in rats under intermittent Pb exposure. For that, arterial blood pressure (BP) and ECG were recorded in 28 weeks old animal and low frequencies (LF) and high frequencies (HF) were determined (to estimate sympathetic and parasympathetic activities) using FisioSinal software with Wavelet module. Preliminary results: Rats intermittently exposed to lead showed a significant decrease in systolic BP (126 ± 4 vs 144 ± 3 mmHg) with no significant changes in LF, HF and LF/HF bands (1.5 ± 0.3 vs 1.7 ± 0.5 mmHg2, 1.9 ± 0.7 vs 2.8 ± 1.2 bpm2 and 1.2 ± 0.4 vs 1.1 ± 0.3 mmHg2/bpm2, respectively) when compared to chronically Pb exposed rats. Our data suggests that the autonomic dysfunction induced by lead exposure is similar in a chronic and intermittent Pb exposure. Nevertheless, it seems that an intermittent exposure was no effect on systolic BP values.The present study brings new insights on the environmental factors that influence autonomic and cardiovascular systems during development, which can help apprise public policy strategies to prevent and control the adverse effects of Pb toxicity. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-22T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.34629/ipl.isel.i-ETC.28 oai:i-ETC.journals.isel.pt:article/28 |
url |
https://doi.org/10.34629/ipl.isel.i-ETC.28 |
identifier_str_mv |
oai:i-ETC.journals.isel.pt:article/28 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://journals.isel.pt/index.php/i-ETC/article/view/28 https://doi.org/10.34629/ipl.isel.i-ETC.28 http://journals.isel.pt/index.php/i-ETC/article/view/28/37 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Liana Shvachiy, Vera Geraldes, Mafalda Carvalho, Isabel Rocha http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Liana Shvachiy, Vera Geraldes, Mafalda Carvalho, Isabel Rocha http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
ISEL - High Institute of Engineering of Lisbon |
publisher.none.fl_str_mv |
ISEL - High Institute of Engineering of Lisbon |
dc.source.none.fl_str_mv |
i-ETC : ISEL Academic Journal of Electronics Telecommunications and Computers; Vol 3, No 1 (2017): The CETC2016 Issue (A); ID-11 i-ETC : ISEL Academic Journal of Electronics Telecommunications and Computers; Vol 3, No 1 (2017): The CETC2016 Issue (A); ID-11 2182-4010 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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