Controlled release gelatin hydrogels and lyophilisates with potential application as ocular inserts

Detalhes bibliográficos
Autor(a) principal: Natu, Mădălina
Data de Publicação: 2007
Outros Autores: Sardinha, José, Correia, Ilídio Joaquim Sobreira, Gil, Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/4621
Resumo: Hydrogels and lyophilisates were obtained by chemical crosslinking of gelatin using N-hydroxysuccinimide and N, N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride. The systems were characterized with respect to the degree of crosslinking, morphology, water uptake, in vitro drug release and biocompatibility studies. Pilocarpine hydrochloride, a drug for the treatment of glaucoma, was loaded by soaking in an aqueous solution containing the drug. In vitro, the released drug percentage varied between 29.2% and 99.2% in 8 h of study. The release data were fitted to the Korsmeyer–Peppas equation to calculate the release exponent, which indicated anomalous transport for the release of pilocarpine. The corneal endothelial cell culture tests indicated that the prepared biomaterials are not cytotoxic.
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spelling Controlled release gelatin hydrogels and lyophilisates with potential application as ocular insertsHydrogelGelatinHydrogels and lyophilisates were obtained by chemical crosslinking of gelatin using N-hydroxysuccinimide and N, N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride. The systems were characterized with respect to the degree of crosslinking, morphology, water uptake, in vitro drug release and biocompatibility studies. Pilocarpine hydrochloride, a drug for the treatment of glaucoma, was loaded by soaking in an aqueous solution containing the drug. In vitro, the released drug percentage varied between 29.2% and 99.2% in 8 h of study. The release data were fitted to the Korsmeyer–Peppas equation to calculate the release exponent, which indicated anomalous transport for the release of pilocarpine. The corneal endothelial cell culture tests indicated that the prepared biomaterials are not cytotoxic.IOPSCIENCEuBibliorumNatu, MădălinaSardinha, JoséCorreia, Ilídio Joaquim SobreiraGil, Maria2018-03-15T15:41:39Z2007-10-082007-10-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4621engNatu, M.V., Sardinha, J.P., Correia, I. J. e Gil, M.H. (2007) “Controlled Release Gelatin Hydrogels and Lyophilisates with Potential Application as Ocular Inserts”, Biomedical Materials, Vol. 2(4), pp. 241-24910.1088/1748-6041/2/4/006metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T03:47:17Zoai:ubibliorum.ubi.pt:10400.6/4621Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:45:41.121258Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Controlled release gelatin hydrogels and lyophilisates with potential application as ocular inserts
title Controlled release gelatin hydrogels and lyophilisates with potential application as ocular inserts
spellingShingle Controlled release gelatin hydrogels and lyophilisates with potential application as ocular inserts
Natu, Mădălina
Hydrogel
Gelatin
title_short Controlled release gelatin hydrogels and lyophilisates with potential application as ocular inserts
title_full Controlled release gelatin hydrogels and lyophilisates with potential application as ocular inserts
title_fullStr Controlled release gelatin hydrogels and lyophilisates with potential application as ocular inserts
title_full_unstemmed Controlled release gelatin hydrogels and lyophilisates with potential application as ocular inserts
title_sort Controlled release gelatin hydrogels and lyophilisates with potential application as ocular inserts
author Natu, Mădălina
author_facet Natu, Mădălina
Sardinha, José
Correia, Ilídio Joaquim Sobreira
Gil, Maria
author_role author
author2 Sardinha, José
Correia, Ilídio Joaquim Sobreira
Gil, Maria
author2_role author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Natu, Mădălina
Sardinha, José
Correia, Ilídio Joaquim Sobreira
Gil, Maria
dc.subject.por.fl_str_mv Hydrogel
Gelatin
topic Hydrogel
Gelatin
description Hydrogels and lyophilisates were obtained by chemical crosslinking of gelatin using N-hydroxysuccinimide and N, N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride. The systems were characterized with respect to the degree of crosslinking, morphology, water uptake, in vitro drug release and biocompatibility studies. Pilocarpine hydrochloride, a drug for the treatment of glaucoma, was loaded by soaking in an aqueous solution containing the drug. In vitro, the released drug percentage varied between 29.2% and 99.2% in 8 h of study. The release data were fitted to the Korsmeyer–Peppas equation to calculate the release exponent, which indicated anomalous transport for the release of pilocarpine. The corneal endothelial cell culture tests indicated that the prepared biomaterials are not cytotoxic.
publishDate 2007
dc.date.none.fl_str_mv 2007-10-08
2007-10-08T00:00:00Z
2018-03-15T15:41:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/4621
url http://hdl.handle.net/10400.6/4621
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Natu, M.V., Sardinha, J.P., Correia, I. J. e Gil, M.H. (2007) “Controlled Release Gelatin Hydrogels and Lyophilisates with Potential Application as Ocular Inserts”, Biomedical Materials, Vol. 2(4), pp. 241-249
10.1088/1748-6041/2/4/006
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IOPSCIENCE
publisher.none.fl_str_mv IOPSCIENCE
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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