Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/54879 |
Resumo: | Emerging pollutants impose a high degree of stress on marine ecosystems, compromising valuable resources, the planet and human health. Pharmaceutical residues often reach marine ecosystems, and their input is directly related to human activities. Fluoxetine is an antidepressant, and one of the most prescribed selective serotonin reuptake inhibitors globally and has been detected in aquatic ecosystems in concentrations up to 40 μg L−1 . The present study aims to evaluate the impact of fluoxetine ecotoxicity on the photochemistry, energy metabolism and enzyme activity of Ulva lactuca exposed to environmentally relevant concentrations (0.3, 0.6, 20, 40, and 80 μg L−1 ). Exogenous fluoxetine exposure induced negative impacts on U. lactuca photochemistry, namely on photosystem II antennae grouping and energy fluxes. These impacts included increased oxidative stress and elevated enzymatic activity of ascorbate peroxidase and glutathione reductase. Lipid content increased and the altered levels of key fatty acids such as hexadecadienoic (C16:2) and linoleic (C18:2) acids revealed strong correlations with fluoxetine concentrations tested. Multivariate analyses reinforced the oxidative stress and chlorophyll a fluorescence-derived traits as efficient biomarkers for future toxicology studies. |
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Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactucaAntidepressantsMacroalgaeOxidative stressPharmaceuticalsPhotobiologyEmerging pollutants impose a high degree of stress on marine ecosystems, compromising valuable resources, the planet and human health. Pharmaceutical residues often reach marine ecosystems, and their input is directly related to human activities. Fluoxetine is an antidepressant, and one of the most prescribed selective serotonin reuptake inhibitors globally and has been detected in aquatic ecosystems in concentrations up to 40 μg L−1 . The present study aims to evaluate the impact of fluoxetine ecotoxicity on the photochemistry, energy metabolism and enzyme activity of Ulva lactuca exposed to environmentally relevant concentrations (0.3, 0.6, 20, 40, and 80 μg L−1 ). Exogenous fluoxetine exposure induced negative impacts on U. lactuca photochemistry, namely on photosystem II antennae grouping and energy fluxes. These impacts included increased oxidative stress and elevated enzymatic activity of ascorbate peroxidase and glutathione reductase. Lipid content increased and the altered levels of key fatty acids such as hexadecadienoic (C16:2) and linoleic (C18:2) acids revealed strong correlations with fluoxetine concentrations tested. Multivariate analyses reinforced the oxidative stress and chlorophyll a fluorescence-derived traits as efficient biomarkers for future toxicology studies.FrontiersRepositório da Universidade de LisboaFeijão, EduardoCruz de Carvalho, RicardoDuarte, Irina A.Matos, Ana RitaCabrita, Maria TeresaUtkin, Andrei B.Caçador, IsabelMarques, João CarlosNovais, Sara C.Lemos, Marco F. L.Reis-Santos, PatrickFonseca, Vanessa F.Duarte, Bernardo2022-10-25T15:23:25Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54879engFeijão, E., Cruz de Carvalho, R., Duarte, Irina A., Matos, A. R., Cabrita, M. T., Utkin, A. B., Caçador, I., Marques J. C., Novais, S. C., Lemos, M. F. L., Reis-Santos, P., Fonseca, V. F. & Duarte, B. (2022). Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca. Frontiers in Environmental Science, 10, 963537. https://doi.org/10.3389/fenvs.2022.9635372296-665X10.3389/fenvs.2022.963537info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:01:35Zoai:repositorio.ul.pt:10451/54879Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:39.106117Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca |
title |
Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca |
spellingShingle |
Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca Feijão, Eduardo Antidepressants Macroalgae Oxidative stress Pharmaceuticals Photobiology |
title_short |
Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca |
title_full |
Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca |
title_fullStr |
Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca |
title_full_unstemmed |
Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca |
title_sort |
Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca |
author |
Feijão, Eduardo |
author_facet |
Feijão, Eduardo Cruz de Carvalho, Ricardo Duarte, Irina A. Matos, Ana Rita Cabrita, Maria Teresa Utkin, Andrei B. Caçador, Isabel Marques, João Carlos Novais, Sara C. Lemos, Marco F. L. Reis-Santos, Patrick Fonseca, Vanessa F. Duarte, Bernardo |
author_role |
author |
author2 |
Cruz de Carvalho, Ricardo Duarte, Irina A. Matos, Ana Rita Cabrita, Maria Teresa Utkin, Andrei B. Caçador, Isabel Marques, João Carlos Novais, Sara C. Lemos, Marco F. L. Reis-Santos, Patrick Fonseca, Vanessa F. Duarte, Bernardo |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Feijão, Eduardo Cruz de Carvalho, Ricardo Duarte, Irina A. Matos, Ana Rita Cabrita, Maria Teresa Utkin, Andrei B. Caçador, Isabel Marques, João Carlos Novais, Sara C. Lemos, Marco F. L. Reis-Santos, Patrick Fonseca, Vanessa F. Duarte, Bernardo |
dc.subject.por.fl_str_mv |
Antidepressants Macroalgae Oxidative stress Pharmaceuticals Photobiology |
topic |
Antidepressants Macroalgae Oxidative stress Pharmaceuticals Photobiology |
description |
Emerging pollutants impose a high degree of stress on marine ecosystems, compromising valuable resources, the planet and human health. Pharmaceutical residues often reach marine ecosystems, and their input is directly related to human activities. Fluoxetine is an antidepressant, and one of the most prescribed selective serotonin reuptake inhibitors globally and has been detected in aquatic ecosystems in concentrations up to 40 μg L−1 . The present study aims to evaluate the impact of fluoxetine ecotoxicity on the photochemistry, energy metabolism and enzyme activity of Ulva lactuca exposed to environmentally relevant concentrations (0.3, 0.6, 20, 40, and 80 μg L−1 ). Exogenous fluoxetine exposure induced negative impacts on U. lactuca photochemistry, namely on photosystem II antennae grouping and energy fluxes. These impacts included increased oxidative stress and elevated enzymatic activity of ascorbate peroxidase and glutathione reductase. Lipid content increased and the altered levels of key fatty acids such as hexadecadienoic (C16:2) and linoleic (C18:2) acids revealed strong correlations with fluoxetine concentrations tested. Multivariate analyses reinforced the oxidative stress and chlorophyll a fluorescence-derived traits as efficient biomarkers for future toxicology studies. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-25T15:23:25Z 2022 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/54879 |
url |
http://hdl.handle.net/10451/54879 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Feijão, E., Cruz de Carvalho, R., Duarte, Irina A., Matos, A. R., Cabrita, M. T., Utkin, A. B., Caçador, I., Marques J. C., Novais, S. C., Lemos, M. F. L., Reis-Santos, P., Fonseca, V. F. & Duarte, B. (2022). Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca. Frontiers in Environmental Science, 10, 963537. https://doi.org/10.3389/fenvs.2022.963537 2296-665X 10.3389/fenvs.2022.963537 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers |
publisher.none.fl_str_mv |
Frontiers |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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