Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children

Detalhes bibliográficos
Autor(a) principal: Aguiar, Laura
Data de Publicação: 2019
Outros Autores: Marinho, Cláudia, Martins, Rute, Alho, Irina, Ferreira, Joana, Levy, Pilar Quinhones, Faustino, Paula, Bicho, Manuel, Inácio, Angela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/58798
Resumo: © 2019 by the C.M.B. Association. All rights reserved
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network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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spelling Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese childrenGene interactionGlutathioneHFEHaptoglobinInflammationObesity© 2019 by the C.M.B. Association. All rights reservedObesity among children has emerged as a serious public health problem. The growing prevalence of childhood obesity has led to the appearance of serious complications, including a chronic systemic inflammation associated with oxidative stress. In the present study, we analysed the interaction between two genes related with iron metabolism - HFE and haptoglobin - and the plasmatic concentration of glutathione, as a way to evaluate the antioxidant response capacity in obesity. To achieve this, 118 obese children and 89 eutrophic children were recruited for the study. Results showed that although obese children present a significantly decreased tGSH levels, once we analysed separately children based on their haptoglobin phenotype, the decreased tGSH levels is significant only for the Hp 2 allele. Additionally, Hp 2.2 obese children carrying H63D polymorphism show significantly lower tGSH/GSSG values. Our results found an association of haptoglobin and HFE with oxidative stress in childhood obesity.CMB AssociationRepositório da Universidade de LisboaAguiar, LauraMarinho, CláudiaMartins, RuteAlho, IrinaFerreira, JoanaLevy, Pilar QuinhonesFaustino, PaulaBicho, ManuelInácio, Angela2023-07-31T13:03:48Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/58798engCell Mol Biol (Noisy-le-grand). 2019 Feb 28;65(2):69-740145-568010.14715/cmb/2019.65.2.111165-158Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:07:44Zoai:repositorio.ul.pt:10451/58798Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:08:55.791755Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
title Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
spellingShingle Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
Aguiar, Laura
Gene interaction
Glutathione
HFE
Haptoglobin
Inflammation
Obesity
title_short Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
title_full Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
title_fullStr Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
title_full_unstemmed Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
title_sort Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese children
author Aguiar, Laura
author_facet Aguiar, Laura
Marinho, Cláudia
Martins, Rute
Alho, Irina
Ferreira, Joana
Levy, Pilar Quinhones
Faustino, Paula
Bicho, Manuel
Inácio, Angela
author_role author
author2 Marinho, Cláudia
Martins, Rute
Alho, Irina
Ferreira, Joana
Levy, Pilar Quinhones
Faustino, Paula
Bicho, Manuel
Inácio, Angela
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Aguiar, Laura
Marinho, Cláudia
Martins, Rute
Alho, Irina
Ferreira, Joana
Levy, Pilar Quinhones
Faustino, Paula
Bicho, Manuel
Inácio, Angela
dc.subject.por.fl_str_mv Gene interaction
Glutathione
HFE
Haptoglobin
Inflammation
Obesity
topic Gene interaction
Glutathione
HFE
Haptoglobin
Inflammation
Obesity
description © 2019 by the C.M.B. Association. All rights reserved
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2023-07-31T13:03:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/58798
url http://hdl.handle.net/10451/58798
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cell Mol Biol (Noisy-le-grand). 2019 Feb 28;65(2):69-74
0145-5680
10.14715/cmb/2019.65.2.11
1165-158X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv CMB Association
publisher.none.fl_str_mv CMB Association
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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