Red alert: labile heme is an alarmin

Detalhes bibliográficos
Autor(a) principal: Soares, Miguel P
Data de Publicação: 2016
Outros Autores: Bozza, Marcelo T
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/769
Resumo: Alarmins are a heterogeneous group of endogenous molecules that signal cellular damage when sensed extracellularly. Heme is an endogenous molecule that acts as a prosthetic group of hemoproteins, such as hemoglobin and myoglobin. When released from damaged red blood cells or muscle cells, oxidized hemoglobin and myoglobin release their prosthetic heme groups, respectively. This generates labile heme, which is sensed by pattern recognition receptors (PRR) expressed by innate immune cells and possibly regulatory T cells (TREG). The ensuing adaptive response, which alerts for the occurrence of red blood cell or muscle cell damage, regulates the pathologic outcome of hemolysis or rhabdomyolysis, respectively. In conclusion, we propose that labile heme is an alarmin.
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spelling Red alert: labile heme is an alarminAdaptive ImmunityAlarminsAnimalsEndothelial CellsErythrocytesGene Expression RegulationHemeHumansMacrophagesMuscle CellsNeutrophilsReactive Oxygen SpeciesReceptors, Pattern RecognitionSignal TransductionImmunity, InnateAlarmins are a heterogeneous group of endogenous molecules that signal cellular damage when sensed extracellularly. Heme is an endogenous molecule that acts as a prosthetic group of hemoproteins, such as hemoglobin and myoglobin. When released from damaged red blood cells or muscle cells, oxidized hemoglobin and myoglobin release their prosthetic heme groups, respectively. This generates labile heme, which is sensed by pattern recognition receptors (PRR) expressed by innate immune cells and possibly regulatory T cells (TREG). The ensuing adaptive response, which alerts for the occurrence of red blood cell or muscle cell damage, regulates the pathologic outcome of hemolysis or rhabdomyolysis, respectively. In conclusion, we propose that labile heme is an alarmin.ElsevierARCASoares, Miguel PBozza, Marcelo T2018-02-01T01:30:09Z2016-022016-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/769eng10.1016/j.coi.2015.11.006info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-21T14:19:33Zoai:arca.igc.gulbenkian.pt:10400.7/769Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-21T14:19:33Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Red alert: labile heme is an alarmin
title Red alert: labile heme is an alarmin
spellingShingle Red alert: labile heme is an alarmin
Soares, Miguel P
Adaptive Immunity
Alarmins
Animals
Endothelial Cells
Erythrocytes
Gene Expression Regulation
Heme
Humans
Macrophages
Muscle Cells
Neutrophils
Reactive Oxygen Species
Receptors, Pattern Recognition
Signal Transduction
Immunity, Innate
title_short Red alert: labile heme is an alarmin
title_full Red alert: labile heme is an alarmin
title_fullStr Red alert: labile heme is an alarmin
title_full_unstemmed Red alert: labile heme is an alarmin
title_sort Red alert: labile heme is an alarmin
author Soares, Miguel P
author_facet Soares, Miguel P
Bozza, Marcelo T
author_role author
author2 Bozza, Marcelo T
author2_role author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Soares, Miguel P
Bozza, Marcelo T
dc.subject.por.fl_str_mv Adaptive Immunity
Alarmins
Animals
Endothelial Cells
Erythrocytes
Gene Expression Regulation
Heme
Humans
Macrophages
Muscle Cells
Neutrophils
Reactive Oxygen Species
Receptors, Pattern Recognition
Signal Transduction
Immunity, Innate
topic Adaptive Immunity
Alarmins
Animals
Endothelial Cells
Erythrocytes
Gene Expression Regulation
Heme
Humans
Macrophages
Muscle Cells
Neutrophils
Reactive Oxygen Species
Receptors, Pattern Recognition
Signal Transduction
Immunity, Innate
description Alarmins are a heterogeneous group of endogenous molecules that signal cellular damage when sensed extracellularly. Heme is an endogenous molecule that acts as a prosthetic group of hemoproteins, such as hemoglobin and myoglobin. When released from damaged red blood cells or muscle cells, oxidized hemoglobin and myoglobin release their prosthetic heme groups, respectively. This generates labile heme, which is sensed by pattern recognition receptors (PRR) expressed by innate immune cells and possibly regulatory T cells (TREG). The ensuing adaptive response, which alerts for the occurrence of red blood cell or muscle cell damage, regulates the pathologic outcome of hemolysis or rhabdomyolysis, respectively. In conclusion, we propose that labile heme is an alarmin.
publishDate 2016
dc.date.none.fl_str_mv 2016-02
2016-02-01T00:00:00Z
2018-02-01T01:30:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/769
url http://hdl.handle.net/10400.7/769
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.coi.2015.11.006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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