Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behavior
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/100221 https://doi.org/10.7554/eLife.75722 |
Resumo: | In humans, ageing is characterized by decreased brain signal variability and increased behavioral variability. To understand how reduced brain variability segregates with increased behavioral variability, we investigated the association between reaction time variability, evoked brain responses and ongoing brain signal dynamics, in young (N=36) and older adults (N=39). We studied the electroencephalogram (EEG) and pupil size fluctuations to characterize the cortical and arousal responses elicited by a cued go/no-go task. Evoked responses were strongly modulated by slow (<2 Hz) fluctuations of the ongoing signals, which presented reduced power in the older participants. Although variability of the evoked responses was lower in the older participants, once we adjusted for the effect of the ongoing signal fluctuations, evoked responses were equally variable in both groups. Moreover, the modulation of the evoked responses caused by the ongoing signal fluctuations had no impact on reaction time, thereby explaining why although ongoing brain signal variability is decreased in older individuals, behavioral variability is not. Finally, we showed that adjusting for the effect of the ongoing signal was critical to unmask the link between neural responses and behavior as well as the link between task-related evoked EEG and pupil responses. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behaviorEEGagingbrain variabilityhumanneurosciencepupilreaction time variabilityIn humans, ageing is characterized by decreased brain signal variability and increased behavioral variability. To understand how reduced brain variability segregates with increased behavioral variability, we investigated the association between reaction time variability, evoked brain responses and ongoing brain signal dynamics, in young (N=36) and older adults (N=39). We studied the electroencephalogram (EEG) and pupil size fluctuations to characterize the cortical and arousal responses elicited by a cued go/no-go task. Evoked responses were strongly modulated by slow (<2 Hz) fluctuations of the ongoing signals, which presented reduced power in the older participants. Although variability of the evoked responses was lower in the older participants, once we adjusted for the effect of the ongoing signal fluctuations, evoked responses were equally variable in both groups. Moreover, the modulation of the evoked responses caused by the ongoing signal fluctuations had no impact on reaction time, thereby explaining why although ongoing brain signal variability is decreased in older individuals, behavioral variability is not. Finally, we showed that adjusting for the effect of the ongoing signal was critical to unmask the link between neural responses and behavior as well as the link between task-related evoked EEG and pupil responses.eLife Sciences Publications2022-05-24info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/100221http://hdl.handle.net/10316/100221https://doi.org/10.7554/eLife.75722eng2050-084X356081642050-084X356081642050-084X2050-084X35608164356081642050-084XRibeiro, MariaCastelo-Branco, Miguelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-27T21:20:41Zoai:estudogeral.uc.pt:10316/100221Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:17:39.779320Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behavior |
title |
Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behavior |
spellingShingle |
Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behavior Ribeiro, Maria EEG aging brain variability human neuroscience pupil reaction time variability |
title_short |
Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behavior |
title_full |
Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behavior |
title_fullStr |
Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behavior |
title_full_unstemmed |
Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behavior |
title_sort |
Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behavior |
author |
Ribeiro, Maria |
author_facet |
Ribeiro, Maria Castelo-Branco, Miguel |
author_role |
author |
author2 |
Castelo-Branco, Miguel |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Ribeiro, Maria Castelo-Branco, Miguel |
dc.subject.por.fl_str_mv |
EEG aging brain variability human neuroscience pupil reaction time variability |
topic |
EEG aging brain variability human neuroscience pupil reaction time variability |
description |
In humans, ageing is characterized by decreased brain signal variability and increased behavioral variability. To understand how reduced brain variability segregates with increased behavioral variability, we investigated the association between reaction time variability, evoked brain responses and ongoing brain signal dynamics, in young (N=36) and older adults (N=39). We studied the electroencephalogram (EEG) and pupil size fluctuations to characterize the cortical and arousal responses elicited by a cued go/no-go task. Evoked responses were strongly modulated by slow (<2 Hz) fluctuations of the ongoing signals, which presented reduced power in the older participants. Although variability of the evoked responses was lower in the older participants, once we adjusted for the effect of the ongoing signal fluctuations, evoked responses were equally variable in both groups. Moreover, the modulation of the evoked responses caused by the ongoing signal fluctuations had no impact on reaction time, thereby explaining why although ongoing brain signal variability is decreased in older individuals, behavioral variability is not. Finally, we showed that adjusting for the effect of the ongoing signal was critical to unmask the link between neural responses and behavior as well as the link between task-related evoked EEG and pupil responses. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-24 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/100221 http://hdl.handle.net/10316/100221 https://doi.org/10.7554/eLife.75722 |
url |
http://hdl.handle.net/10316/100221 https://doi.org/10.7554/eLife.75722 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2050-084X 35608164 2050-084X 35608164 2050-084X 2050-084X 35608164 35608164 2050-084X |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
eLife Sciences Publications |
publisher.none.fl_str_mv |
eLife Sciences Publications |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134072281235456 |