Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration

Detalhes bibliográficos
Autor(a) principal: Mateus, Rita
Data de Publicação: 2015
Outros Autores: Lourenço, Raquel, Fang, Y., Brito, G, Farinho, Ana, Valerio, Fabio, Jacinto, António
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/26612
Resumo: This work was supported by funding from Fundacao para a Ciencia e Tecnologia [SFRH/BD/62126/2009, PTDC/BEX-BID/1176/2012]; and Agence Nationale de la Recherche [ANR-11-BSV5-0021].
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network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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spelling Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regenerationEXPRESSIONCONTACT INHIBITIONPROTEIN YAPTRANSCRIPTIONAL COACTIVATORZebrafishCell densityHippo/YapPROLIFERATIONAPOPTOSISCATENINDROSOPHILAFin regenerationF-actinINDUCTIONHIPPO SIGNALING PATHWAYThis work was supported by funding from Fundacao para a Ciencia e Tecnologia [SFRH/BD/62126/2009, PTDC/BEX-BID/1176/2012]; and Agence Nationale de la Recherche [ANR-11-BSV5-0021].Caudal fin regeneration is characterized by a proliferation boost in the mesenchymal blastema that is controlled precisely in time and space. This allows a gradual and robust restoration of original fin size. However, how this is established and regulated is not well understood. Here, we report that Yap, the Hippo pathway effector, is a chief player in this process: functionally manipulating Yap during regeneration dramatically affects cell proliferation and expression of key signaling pathways, impacting regenerative growth. The intracellular location of Yap is tightly associated with different cell densities along the blastema proximal-distal axis, which correlate with alterations in cell morphology, cytoskeleton and cell-cell contacts in a gradient-like manner. Importantly, Yap inactivation occurs in high cell density areas, conditional to F-actin distribution and polymerization. We propose that Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNMateus, RitaLourenço, RaquelFang, Y.Brito, GFarinho, AnaValerio, FabioJacinto, António2017-12-11T23:05:47Z2015-08-152015-08-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://hdl.handle.net/10362/26612eng0950-1991PURE: 497717https://doi.org/10.1242/dev.119701info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:13:59Zoai:run.unl.pt:10362/26612Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:28:30.940818Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration
title Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration
spellingShingle Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration
Mateus, Rita
EXPRESSION
CONTACT INHIBITION
PROTEIN YAP
TRANSCRIPTIONAL COACTIVATOR
Zebrafish
Cell density
Hippo/Yap
PROLIFERATION
APOPTOSIS
CATENIN
DROSOPHILA
Fin regeneration
F-actin
INDUCTION
HIPPO SIGNALING PATHWAY
title_short Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration
title_full Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration
title_fullStr Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration
title_full_unstemmed Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration
title_sort Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration
author Mateus, Rita
author_facet Mateus, Rita
Lourenço, Raquel
Fang, Y.
Brito, G
Farinho, Ana
Valerio, Fabio
Jacinto, António
author_role author
author2 Lourenço, Raquel
Fang, Y.
Brito, G
Farinho, Ana
Valerio, Fabio
Jacinto, António
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Mateus, Rita
Lourenço, Raquel
Fang, Y.
Brito, G
Farinho, Ana
Valerio, Fabio
Jacinto, António
dc.subject.por.fl_str_mv EXPRESSION
CONTACT INHIBITION
PROTEIN YAP
TRANSCRIPTIONAL COACTIVATOR
Zebrafish
Cell density
Hippo/Yap
PROLIFERATION
APOPTOSIS
CATENIN
DROSOPHILA
Fin regeneration
F-actin
INDUCTION
HIPPO SIGNALING PATHWAY
topic EXPRESSION
CONTACT INHIBITION
PROTEIN YAP
TRANSCRIPTIONAL COACTIVATOR
Zebrafish
Cell density
Hippo/Yap
PROLIFERATION
APOPTOSIS
CATENIN
DROSOPHILA
Fin regeneration
F-actin
INDUCTION
HIPPO SIGNALING PATHWAY
description This work was supported by funding from Fundacao para a Ciencia e Tecnologia [SFRH/BD/62126/2009, PTDC/BEX-BID/1176/2012]; and Agence Nationale de la Recherche [ANR-11-BSV5-0021].
publishDate 2015
dc.date.none.fl_str_mv 2015-08-15
2015-08-15T00:00:00Z
2017-12-11T23:05:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/26612
url http://hdl.handle.net/10362/26612
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0950-1991
PURE: 497717
https://doi.org/10.1242/dev.119701
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137910473097216

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