Fatal intoxication with tianeptine (Stablon®)
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/4712 https://doi.org/10.1016/j.forsciint.2007.03.035 |
Resumo: | Tianeptine (Stablon®), although structurally similar to tricyclic antidepressants, acts by enhancing the reuptake of serotonin. A fatal case is presented involving a 26-year-old man, found lying in bed with a "mushroom of foam" around his mouth. Empty blister packs of Stablon® and a suicide note were found next to the body. A liquid-liquid extraction procedure with n-hexane: ethyl acetate and n-hexane: 2-propanol, followed by LC-DAD-MS analysis, using positive mode electrospray ionization was performed. The detection limit was 0.001 [mu]g/mL. The toxicological results revealed the following tianeptine concentrations in the post-mortem samples: blood 5.1 [mu]g/mL; urine 2.0 [mu]g/mL; liver 23 [mu]g/g; stomach contents 22 mg. Femoral blood analyses also revealed an ethanol concentration of 0.53 g/L. The present method was also developed and validated for the other post-mortem specimens, since no previous published data had confirmed the post-mortem distribution of tianeptine. The absence of other suitable direct causes of death (macroscopic or histological) and the positive results achieved with the toxicological analysis led the pathologist to rule that death was due to an intoxication caused by the suicidal ingestion of tianeptine in combination with alcohol. |
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Fatal intoxication with tianeptine (Stablon®)SuicidePoisoningTianeptinePost-mortem distributionTianeptine (Stablon®), although structurally similar to tricyclic antidepressants, acts by enhancing the reuptake of serotonin. A fatal case is presented involving a 26-year-old man, found lying in bed with a "mushroom of foam" around his mouth. Empty blister packs of Stablon® and a suicide note were found next to the body. A liquid-liquid extraction procedure with n-hexane: ethyl acetate and n-hexane: 2-propanol, followed by LC-DAD-MS analysis, using positive mode electrospray ionization was performed. The detection limit was 0.001 [mu]g/mL. The toxicological results revealed the following tianeptine concentrations in the post-mortem samples: blood 5.1 [mu]g/mL; urine 2.0 [mu]g/mL; liver 23 [mu]g/g; stomach contents 22 mg. Femoral blood analyses also revealed an ethanol concentration of 0.53 g/L. The present method was also developed and validated for the other post-mortem specimens, since no previous published data had confirmed the post-mortem distribution of tianeptine. The absence of other suitable direct causes of death (macroscopic or histological) and the positive results achieved with the toxicological analysis led the pathologist to rule that death was due to an intoxication caused by the suicidal ingestion of tianeptine in combination with alcohol.http://www.sciencedirect.com/science/article/B6T6W-4P5YK4N-5/1/f4c68b859971f524767ae38bfb6811082007info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/4712http://hdl.handle.net/10316/4712https://doi.org/10.1016/j.forsciint.2007.03.035engForensic Science International. 170:2-3 (2007) 200-203Proença, PaulaTeixeira, HelenaPinheiro, JoãoMonsanto, Paula V.Vieira, Duarte Nunoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-11-06T16:49:05Zoai:estudogeral.uc.pt:10316/4712Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:43:26.611092Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Fatal intoxication with tianeptine (Stablon®) |
title |
Fatal intoxication with tianeptine (Stablon®) |
spellingShingle |
Fatal intoxication with tianeptine (Stablon®) Proença, Paula Suicide Poisoning Tianeptine Post-mortem distribution |
title_short |
Fatal intoxication with tianeptine (Stablon®) |
title_full |
Fatal intoxication with tianeptine (Stablon®) |
title_fullStr |
Fatal intoxication with tianeptine (Stablon®) |
title_full_unstemmed |
Fatal intoxication with tianeptine (Stablon®) |
title_sort |
Fatal intoxication with tianeptine (Stablon®) |
author |
Proença, Paula |
author_facet |
Proença, Paula Teixeira, Helena Pinheiro, João Monsanto, Paula V. Vieira, Duarte Nuno |
author_role |
author |
author2 |
Teixeira, Helena Pinheiro, João Monsanto, Paula V. Vieira, Duarte Nuno |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Proença, Paula Teixeira, Helena Pinheiro, João Monsanto, Paula V. Vieira, Duarte Nuno |
dc.subject.por.fl_str_mv |
Suicide Poisoning Tianeptine Post-mortem distribution |
topic |
Suicide Poisoning Tianeptine Post-mortem distribution |
description |
Tianeptine (Stablon®), although structurally similar to tricyclic antidepressants, acts by enhancing the reuptake of serotonin. A fatal case is presented involving a 26-year-old man, found lying in bed with a "mushroom of foam" around his mouth. Empty blister packs of Stablon® and a suicide note were found next to the body. A liquid-liquid extraction procedure with n-hexane: ethyl acetate and n-hexane: 2-propanol, followed by LC-DAD-MS analysis, using positive mode electrospray ionization was performed. The detection limit was 0.001 [mu]g/mL. The toxicological results revealed the following tianeptine concentrations in the post-mortem samples: blood 5.1 [mu]g/mL; urine 2.0 [mu]g/mL; liver 23 [mu]g/g; stomach contents 22 mg. Femoral blood analyses also revealed an ethanol concentration of 0.53 g/L. The present method was also developed and validated for the other post-mortem specimens, since no previous published data had confirmed the post-mortem distribution of tianeptine. The absence of other suitable direct causes of death (macroscopic or histological) and the positive results achieved with the toxicological analysis led the pathologist to rule that death was due to an intoxication caused by the suicidal ingestion of tianeptine in combination with alcohol. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/4712 http://hdl.handle.net/10316/4712 https://doi.org/10.1016/j.forsciint.2007.03.035 |
url |
http://hdl.handle.net/10316/4712 https://doi.org/10.1016/j.forsciint.2007.03.035 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Forensic Science International. 170:2-3 (2007) 200-203 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
aplication/PDF |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133706603986944 |