HFE variants and the expression of iron-related proteins in breast cancer-associated lymphocytes and macrophages

Detalhes bibliográficos
Autor(a) principal: Marques, Oriana
Data de Publicação: 2016
Outros Autores: Rosa, Ana, Leite, Luciana, Faustino, Paula, Rêma, Alexandra, Martins da silva, Berta, Porto, Graça, Lopes, Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/4162
Resumo: Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264664/
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spelling HFE variants and the expression of iron-related proteins in breast cancer-associated lymphocytes and macrophagesBreast CancerHFEHigh Iron FEIronp.Cys282TyrDoenças GenéticasCancroMetabolismo do FerroModificadores GenéticosHepcidinaDisponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264664/The association of HFE (High Iron FE) major variants with breast cancer risk and behavior has been a matter of discussion for a long time. However, their impact on the expression of iron-related proteins in the breast cancer tissue has never been addressed. In the present study, hepcidin, ferroportin 1, transferrin receptor 1 (TfR1), and ferritin expressions, as well as tissue iron deposition were evaluated in a collection of samples from breast cancers patients and analyzed according to the patients’ HFE genotype. Within the group of patients with invasive carcinoma, those carrying the p.Cys282Tyr variant in heterozygosity presented a higher expression of hepcidin in lymphocytes and macrophages than wild-type or p.His63Asp carriers. An increased expression of TfR1 was also observed in all the cell types analyzed but only in p.Cys282Tyr/p.His63Asp compound heterozygous patients. A differential impact of the two HFE variants was further noticed with the observation of a significantly higher percentage of p.Cys282Tyr heterozygous patients presenting tissue iron deposition in comparison to p.His63Asp heterozygous. In the present cohort, no significant associations were found between HFE variants and classical clinicopathological markers of breast cancer behavior and prognosis. Although limited by a low sampling size, our results provide a new possible explanation for the previously reported impact of HFE major variants on breast cancer progression, i.e., not by influencing systemic iron homeostasis but rather by differentially modulating the local cellular expression of iron-related proteins and tissue iron deposition.OM is a recipient of the PhD grant SFRH/BD/2011/78184 from Fundação para a Ciência e Tecnologia (FCT). The authors also acknowledge financial support from ICBAS/AI&NSUMIB and by national funds through FCT and Ministério da Educação e Ciência (MEC) and when applicable co-funded by FEDER funds within the partnership agreement PT2020 related with the research unit number 4293.Springer/International Cancer Microenvironment SocietyRepositório Científico do Instituto Nacional de SaúdeMarques, OrianaRosa, AnaLeite, LucianaFaustino, PaulaRêma, AlexandraMartins da silva, BertaPorto, GraçaLopes, Carlos2017-02-14T13:55:02Z2016-12-272016-12-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4162engCancer Microenviron. 2016 Dec;9(2-3):85-91. doi: 10.1007/s12307-016-0191-4. Epub 2016 Dec 27.1875-229210.1007/s12307-016-0191-4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:12Zoai:repositorio.insa.pt:10400.18/4162Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:38:59.723679Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv HFE variants and the expression of iron-related proteins in breast cancer-associated lymphocytes and macrophages
title HFE variants and the expression of iron-related proteins in breast cancer-associated lymphocytes and macrophages
spellingShingle HFE variants and the expression of iron-related proteins in breast cancer-associated lymphocytes and macrophages
Marques, Oriana
Breast Cancer
HFE
High Iron FE
Iron
p.Cys282Tyr
Doenças Genéticas
Cancro
Metabolismo do Ferro
Modificadores Genéticos
Hepcidina
title_short HFE variants and the expression of iron-related proteins in breast cancer-associated lymphocytes and macrophages
title_full HFE variants and the expression of iron-related proteins in breast cancer-associated lymphocytes and macrophages
title_fullStr HFE variants and the expression of iron-related proteins in breast cancer-associated lymphocytes and macrophages
title_full_unstemmed HFE variants and the expression of iron-related proteins in breast cancer-associated lymphocytes and macrophages
title_sort HFE variants and the expression of iron-related proteins in breast cancer-associated lymphocytes and macrophages
author Marques, Oriana
author_facet Marques, Oriana
Rosa, Ana
Leite, Luciana
Faustino, Paula
Rêma, Alexandra
Martins da silva, Berta
Porto, Graça
Lopes, Carlos
author_role author
author2 Rosa, Ana
Leite, Luciana
Faustino, Paula
Rêma, Alexandra
Martins da silva, Berta
Porto, Graça
Lopes, Carlos
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Marques, Oriana
Rosa, Ana
Leite, Luciana
Faustino, Paula
Rêma, Alexandra
Martins da silva, Berta
Porto, Graça
Lopes, Carlos
dc.subject.por.fl_str_mv Breast Cancer
HFE
High Iron FE
Iron
p.Cys282Tyr
Doenças Genéticas
Cancro
Metabolismo do Ferro
Modificadores Genéticos
Hepcidina
topic Breast Cancer
HFE
High Iron FE
Iron
p.Cys282Tyr
Doenças Genéticas
Cancro
Metabolismo do Ferro
Modificadores Genéticos
Hepcidina
description Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264664/
publishDate 2016
dc.date.none.fl_str_mv 2016-12-27
2016-12-27T00:00:00Z
2017-02-14T13:55:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/4162
url http://hdl.handle.net/10400.18/4162
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cancer Microenviron. 2016 Dec;9(2-3):85-91. doi: 10.1007/s12307-016-0191-4. Epub 2016 Dec 27.
1875-2292
10.1007/s12307-016-0191-4
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer/International Cancer Microenvironment Society
publisher.none.fl_str_mv Springer/International Cancer Microenvironment Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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