Efficacy and Safety of Percutaneous Radiofrequency Thermal Ablation in the Treatment of Lung Cancer Lesions

• Autor(a) principal: Tavares eCastro, Ana
• Data de Publicação: 2015
• Outros Autores: Freitas, Sara, Portilha, Antónia, Alves, Fernando, Caseiro-Alves, Filipe
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5620

Introduction: In this study, we reviewed a clinical series composed by all malignant lung lesions submitted to computed tomographyguided percutaneous thermal radiofrequency ablation, in our hospital, a rather recent technique that has been gaining scientific recognition.Material and Methods: For data purposes, all radiofrequency ablation and corresponding clinical records were retrospectivelyanalysed. A computed tomography scan was performed before and after each procedure to evaluate the tumour’s features, and at a second step to assess results and complications. The frequency of local recurrence and disease progression were determined based on imaging follow-up. Kaplan–Meier analysis was used to estimate survival. Univariate analysis recognized clinical and pathological factors affecting survival. These were also tested by multivariate analysis.Results: A total of 28 malignant lung lesions, 20 primary and 8 metastatic, from 28 patients (78.6% male; mean age 62 ± 17 years old), were submitted to computed tomography-guided radiofrequency ablation between January 2004 and July 2010. Total necrosis was achieved in 74.1% of the lesions. Immediate radiofrequency ablation-related complications were observed in half of the procedures. Among major complications, death occurred in one patient only. Median overall survival was 43.0 months for a mean 2-years follow-up.Median progression-free survival was 31.6 months. Lesion’s size smaller than 35 mm, stage III disease by the TNM classification and previous treatment attempts were significantly associated with better outcomes. Disease-related mortality was 46.4%.Discussion: This procedure proved to be efficient to treat lung cancerous lesions, with a low-rate of major complications.Conclusions: Computed tomography-guided percutaneous radiofrequency ablation is a minimally invasive procedure that appears to be valuable in the treatment of lung cancer lesions.Keywords: Catheter Ablation; Lung Neoplasms; Tomography, X-Ray Computed.