Bifunctionalised long-wavelength fluorescent probes for biological applications

Detalhes bibliográficos
Autor(a) principal: Firmino, A. D. G.
Data de Publicação: 2012
Outros Autores: Gonçalves, M. Sameiro T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/21971
Resumo: The synthesis of benzo[a]phenoxazinium chlorides which are bifunctionalised in position 2 with 4-ethoxy-4-oxobutoxyl, 3-hydroxypropoxyl or 3-chloropropoxyl groups, and in position 9 with the (aminopropyl)amino group, was efficiently performed. The covalent labeling of valine was carried out by using one of the new fluorophores obtained. Photophysical studies in the homogeneous media of ethanol, distilled water and at simulated physiological conditions revealed that all the compounds absorbed and emitted from 610 to 651 nm.
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spelling Bifunctionalised long-wavelength fluorescent probes for biological applicationsBenzo[a]phenoxazinesNile blueLong-wavelength dyesCovalent labellingFluorescent probesScience & TechnologyThe synthesis of benzo[a]phenoxazinium chlorides which are bifunctionalised in position 2 with 4-ethoxy-4-oxobutoxyl, 3-hydroxypropoxyl or 3-chloropropoxyl groups, and in position 9 with the (aminopropyl)amino group, was efficiently performed. The covalent labeling of valine was carried out by using one of the new fluorophores obtained. Photophysical studies in the homogeneous media of ethanol, distilled water and at simulated physiological conditions revealed that all the compounds absorbed and emitted from 610 to 651 nm.Fundação para a Ciência e Tecnologia (FCT, Portugal) - financial support to the NMR portuguese network (PTNMR, Bruker Avance III 400-Univ. Minho), FCT and FEDER (European Fund for Regional Development)-COMPETE-QREN-EU - financial support to the Research Centre, CQ/UM [PEst-C/QUI/UI0686/2011 (FCOMP-01-0124-FEDER-022716)].ElsevierUniversidade do MinhoFirmino, A. D. G.Gonçalves, M. Sameiro T.20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/21971eng0040-403910.1016/j.tetlet.2012.07.004http://www.sciencedirect.com/science/article/pii/S0040403912011707info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:32:48Zoai:repositorium.sdum.uminho.pt:1822/21971Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:28:12.151556Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Bifunctionalised long-wavelength fluorescent probes for biological applications
title Bifunctionalised long-wavelength fluorescent probes for biological applications
spellingShingle Bifunctionalised long-wavelength fluorescent probes for biological applications
Firmino, A. D. G.
Benzo[a]phenoxazines
Nile blue
Long-wavelength dyes
Covalent labelling
Fluorescent probes
Science & Technology
title_short Bifunctionalised long-wavelength fluorescent probes for biological applications
title_full Bifunctionalised long-wavelength fluorescent probes for biological applications
title_fullStr Bifunctionalised long-wavelength fluorescent probes for biological applications
title_full_unstemmed Bifunctionalised long-wavelength fluorescent probes for biological applications
title_sort Bifunctionalised long-wavelength fluorescent probes for biological applications
author Firmino, A. D. G.
author_facet Firmino, A. D. G.
Gonçalves, M. Sameiro T.
author_role author
author2 Gonçalves, M. Sameiro T.
author2_role author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Firmino, A. D. G.
Gonçalves, M. Sameiro T.
dc.subject.por.fl_str_mv Benzo[a]phenoxazines
Nile blue
Long-wavelength dyes
Covalent labelling
Fluorescent probes
Science & Technology
topic Benzo[a]phenoxazines
Nile blue
Long-wavelength dyes
Covalent labelling
Fluorescent probes
Science & Technology
description The synthesis of benzo[a]phenoxazinium chlorides which are bifunctionalised in position 2 with 4-ethoxy-4-oxobutoxyl, 3-hydroxypropoxyl or 3-chloropropoxyl groups, and in position 9 with the (aminopropyl)amino group, was efficiently performed. The covalent labeling of valine was carried out by using one of the new fluorophores obtained. Photophysical studies in the homogeneous media of ethanol, distilled water and at simulated physiological conditions revealed that all the compounds absorbed and emitted from 610 to 651 nm.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/21971
url http://hdl.handle.net/1822/21971
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0040-4039
10.1016/j.tetlet.2012.07.004
http://www.sciencedirect.com/science/article/pii/S0040403912011707
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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