Systemic Photochemotherapy in the Treatment of Adolescent Psoriasis
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.29021/spdv.74.1.515 |
Resumo: | Introduction: Ultraviolet-B radiation is known to be effective and safe in childhood and adolescent psoriasis, but little has been published on the combined use of psoralen with ultraviolet-A radiation. The aim of this work is to assess the efficacy and short-term safety of systemic photochemotherapy in an adolescent population.Methods: Relevant clinical data on psoriatic patients aged 13 to 17 was retrospectively collected and analyzed. The sample population included twenty patients, eighteen with moderate to severe plaque-type psoriasis and two with guttate psoriasis.Results: Nine patients were treated with one single cycle and the remaining eleven with two cycles, in association with systemic therapies in 52%. Total improvement rate was 86.2%, with an average of 16.7 treatments per patient and a mean total cumulative dose of 174.0 J/cm2. The mean time for disease relapse was 4.3 months and two patients (10%) did not experience relapse during one-year follow-up. Side effects occurred in three patients (15%), namely nausea and erythema.Conclusions: Photochemotherapy showed to be highly effective in our adolescent population. Side effects were minor and none led to therapy discontinuation. Carcinogenic potential of ultraviolet-A radiation might be an important limitation. Further studies are warranted to access long-term safety of photochemotherapy. |
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Systemic Photochemotherapy in the Treatment of Adolescent PsoriasisFotoquimioterapia Sistémica no Tratamento de Psoríase na AdolescênciaPhototherapyPsoriasisAdolescentFototerapiaPsoríaseAdolescenteIntroduction: Ultraviolet-B radiation is known to be effective and safe in childhood and adolescent psoriasis, but little has been published on the combined use of psoralen with ultraviolet-A radiation. The aim of this work is to assess the efficacy and short-term safety of systemic photochemotherapy in an adolescent population.Methods: Relevant clinical data on psoriatic patients aged 13 to 17 was retrospectively collected and analyzed. The sample population included twenty patients, eighteen with moderate to severe plaque-type psoriasis and two with guttate psoriasis.Results: Nine patients were treated with one single cycle and the remaining eleven with two cycles, in association with systemic therapies in 52%. Total improvement rate was 86.2%, with an average of 16.7 treatments per patient and a mean total cumulative dose of 174.0 J/cm2. The mean time for disease relapse was 4.3 months and two patients (10%) did not experience relapse during one-year follow-up. Side effects occurred in three patients (15%), namely nausea and erythema.Conclusions: Photochemotherapy showed to be highly effective in our adolescent population. Side effects were minor and none led to therapy discontinuation. Carcinogenic potential of ultraviolet-A radiation might be an important limitation. Further studies are warranted to access long-term safety of photochemotherapy.Introdução: A eficácia e segurança da radiação UVB no tratamento da psoríase infantil e da adolescência encontra-se bem descrita na literatura. Contudo, existem poucos dados no que concerne à utilização de psoraleno e UVA (PUVA) nesta faixa etária. O objectivo do presente trabalho é avaliar a eficácia e segurança a curto prazo da terapêutica com PUVA numa população de adolescentes com psoríase.Métodos: Revisão e análise retrospectiva dos dados clínicos relativos aos doentes com psoríase com idade entre 13 e 17 anos. A população analisada incluiu 20 doentes, dezoito com psoríase em placas moderada a grave e dois com psoríase gutata.Resultados: Nove doentes foram tratados com apenas um ciclo de PUVA, e os restantes com dois. Foram associadas terapêuticas sistémicas em 52%. A taxa de resposta total foi de 86,2%, com uma média global de 16,7 tratamentos de PUVA e uma dose cumulativa total média de 174,0 J/cm2. O tempo até recidiva foi de 4,3 meses, e em 2 doentes (10%) não houve recidiva durante um ano de seguimento. Observaram-se efeitos secundários em 3 doentes (15%), nomeadamente náuseas e eritema cutâneo.Conclusões: A fotoquimioterapia demonstrou boa eficácia na nossa população de adolescentes. Os efeitos secundários foram reduzidos e não motivaram suspensão da terapêutica. O potencial carcinogénico da radiação UVA poderá ser uma limitação importante desta modalidade terapêutica, pelo que são necessários mais estudos que avaliem a sua segurança a longo prazo.Sociedade Portuguesa de Dermatologia e Venereologia2016-04-29T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.74.1.515oai:ojs.revista.spdv.com.pt:article/515Journal of the Portuguese Society of Dermatology and Venereology; Vol 74 No 1 (2016): Janeiro - Março; 53-57Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 74 n. 1 (2016): Janeiro - Março; 53-572182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/515https://doi.org/10.29021/spdv.74.1.515https://revista.spdv.com.pt/index.php/spdv/article/view/515/387Brasileiro, AnaCampos, SaraRocha-Páris, FilipaFidalgo, AnaApetato, Margaridainfo:eu-repo/semantics/openAccess2022-10-06T12:34:56Zoai:ojs.revista.spdv.com.pt:article/515Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:10:55.654939Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Systemic Photochemotherapy in the Treatment of Adolescent Psoriasis Fotoquimioterapia Sistémica no Tratamento de Psoríase na Adolescência |
title |
Systemic Photochemotherapy in the Treatment of Adolescent Psoriasis |
spellingShingle |
Systemic Photochemotherapy in the Treatment of Adolescent Psoriasis Brasileiro, Ana Phototherapy Psoriasis Adolescent Fototerapia Psoríase Adolescente |
title_short |
Systemic Photochemotherapy in the Treatment of Adolescent Psoriasis |
title_full |
Systemic Photochemotherapy in the Treatment of Adolescent Psoriasis |
title_fullStr |
Systemic Photochemotherapy in the Treatment of Adolescent Psoriasis |
title_full_unstemmed |
Systemic Photochemotherapy in the Treatment of Adolescent Psoriasis |
title_sort |
Systemic Photochemotherapy in the Treatment of Adolescent Psoriasis |
author |
Brasileiro, Ana |
author_facet |
Brasileiro, Ana Campos, Sara Rocha-Páris, Filipa Fidalgo, Ana Apetato, Margarida |
author_role |
author |
author2 |
Campos, Sara Rocha-Páris, Filipa Fidalgo, Ana Apetato, Margarida |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Brasileiro, Ana Campos, Sara Rocha-Páris, Filipa Fidalgo, Ana Apetato, Margarida |
dc.subject.por.fl_str_mv |
Phototherapy Psoriasis Adolescent Fototerapia Psoríase Adolescente |
topic |
Phototherapy Psoriasis Adolescent Fototerapia Psoríase Adolescente |
description |
Introduction: Ultraviolet-B radiation is known to be effective and safe in childhood and adolescent psoriasis, but little has been published on the combined use of psoralen with ultraviolet-A radiation. The aim of this work is to assess the efficacy and short-term safety of systemic photochemotherapy in an adolescent population.Methods: Relevant clinical data on psoriatic patients aged 13 to 17 was retrospectively collected and analyzed. The sample population included twenty patients, eighteen with moderate to severe plaque-type psoriasis and two with guttate psoriasis.Results: Nine patients were treated with one single cycle and the remaining eleven with two cycles, in association with systemic therapies in 52%. Total improvement rate was 86.2%, with an average of 16.7 treatments per patient and a mean total cumulative dose of 174.0 J/cm2. The mean time for disease relapse was 4.3 months and two patients (10%) did not experience relapse during one-year follow-up. Side effects occurred in three patients (15%), namely nausea and erythema.Conclusions: Photochemotherapy showed to be highly effective in our adolescent population. Side effects were minor and none led to therapy discontinuation. Carcinogenic potential of ultraviolet-A radiation might be an important limitation. Further studies are warranted to access long-term safety of photochemotherapy. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-04-29T00:00:00Z |
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journal article info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.29021/spdv.74.1.515 oai:ojs.revista.spdv.com.pt:article/515 |
url |
https://doi.org/10.29021/spdv.74.1.515 |
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oai:ojs.revista.spdv.com.pt:article/515 |
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por |
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https://revista.spdv.com.pt/index.php/spdv/article/view/515 https://doi.org/10.29021/spdv.74.1.515 https://revista.spdv.com.pt/index.php/spdv/article/view/515/387 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
dc.source.none.fl_str_mv |
Journal of the Portuguese Society of Dermatology and Venereology; Vol 74 No 1 (2016): Janeiro - Março; 53-57 Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 74 n. 1 (2016): Janeiro - Março; 53-57 2182-2409 2182-2395 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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