Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation.
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/5733 https://doi.org/10.1016/j.jbiomech.2009.12.010 |
Resumo: | Bone mass distribution and structure are dependent on mechanical stress and adaptive response at cellular and tissue levels. Mechanical stimulation of bone induces new bone formation in vivo and increases the metabolic activity and gene expression of osteoblasts in culture. A wide variety of devices have been tested for mechanical stimulation of cells and tissues in vitro. The aim of this work was to experimentally validate the possibility to use piezoelectric materials as a mean of mechanical stimulation of bone cells, by converse piezoelectric effect. To estimate the magnitude and the distribution of strain, finite numerical models were applied and the results were complemented with the optical tests (Electronic Speckle Pattern Interferometric Process). In this work, osteoblasts were grown on the surface of a piezoelectric material, both in static and dynamic conditions at low frequencies, and total protein, cell viability and nitric oxide measurement comparisons are presented. |
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Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation.Polymeric piezoelectricActuatorOsteoblast cellsMechanical stimulationBone mass distribution and structure are dependent on mechanical stress and adaptive response at cellular and tissue levels. Mechanical stimulation of bone induces new bone formation in vivo and increases the metabolic activity and gene expression of osteoblasts in culture. A wide variety of devices have been tested for mechanical stimulation of cells and tissues in vitro. The aim of this work was to experimentally validate the possibility to use piezoelectric materials as a mean of mechanical stimulation of bone cells, by converse piezoelectric effect. To estimate the magnitude and the distribution of strain, finite numerical models were applied and the results were complemented with the optical tests (Electronic Speckle Pattern Interferometric Process). In this work, osteoblasts were grown on the surface of a piezoelectric material, both in static and dynamic conditions at low frequencies, and total protein, cell viability and nitric oxide measurement comparisons are presented.Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation.2012-11-19T12:57:29Z2012-11-192010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/5733http://hdl.handle.net/10174/5733https://doi.org/10.1016/j.jbiomech.2009.12.010engFrias C, Reis J, Capela e Silva F, Potes J, Simões J, Marques AT. Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation. J Biomechanics 2010; 43: 1061-1066.1061-106643Journal of BiomechanicsICAAMndjmfcr@uevora.ptfcs@uevora.ptjacpotes@uevora.ptndnd232Frias, CReis, JCapela e Silva, FPotes, JSimões, JMarques, ATinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T18:44:53Zoai:dspace.uevora.pt:10174/5733Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:00:46.534594Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation. |
title |
Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation. |
spellingShingle |
Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation. Frias, C Polymeric piezoelectric Actuator Osteoblast cells Mechanical stimulation |
title_short |
Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation. |
title_full |
Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation. |
title_fullStr |
Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation. |
title_full_unstemmed |
Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation. |
title_sort |
Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation. |
author |
Frias, C |
author_facet |
Frias, C Reis, J Capela e Silva, F Potes, J Simões, J Marques, AT |
author_role |
author |
author2 |
Reis, J Capela e Silva, F Potes, J Simões, J Marques, AT |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Frias, C Reis, J Capela e Silva, F Potes, J Simões, J Marques, AT |
dc.subject.por.fl_str_mv |
Polymeric piezoelectric Actuator Osteoblast cells Mechanical stimulation |
topic |
Polymeric piezoelectric Actuator Osteoblast cells Mechanical stimulation |
description |
Bone mass distribution and structure are dependent on mechanical stress and adaptive response at cellular and tissue levels. Mechanical stimulation of bone induces new bone formation in vivo and increases the metabolic activity and gene expression of osteoblasts in culture. A wide variety of devices have been tested for mechanical stimulation of cells and tissues in vitro. The aim of this work was to experimentally validate the possibility to use piezoelectric materials as a mean of mechanical stimulation of bone cells, by converse piezoelectric effect. To estimate the magnitude and the distribution of strain, finite numerical models were applied and the results were complemented with the optical tests (Electronic Speckle Pattern Interferometric Process). In this work, osteoblasts were grown on the surface of a piezoelectric material, both in static and dynamic conditions at low frequencies, and total protein, cell viability and nitric oxide measurement comparisons are presented. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01T00:00:00Z 2012-11-19T12:57:29Z 2012-11-19 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/5733 http://hdl.handle.net/10174/5733 https://doi.org/10.1016/j.jbiomech.2009.12.010 |
url |
http://hdl.handle.net/10174/5733 https://doi.org/10.1016/j.jbiomech.2009.12.010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Frias C, Reis J, Capela e Silva F, Potes J, Simões J, Marques AT. Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation. J Biomechanics 2010; 43: 1061-1066. 1061-1066 43 Journal of Biomechanics ICAAM nd jmfcr@uevora.pt fcs@uevora.pt jacpotes@uevora.pt nd nd 232 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation. |
publisher.none.fl_str_mv |
Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136490927685632 |