Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/61031 |
Resumo: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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Design and Characterization of an Ethosomal Gel Encapsulating Rosehip ExtractRosa canina L. extractpolyphenolsantioxidant activityethosomal gelsodium hyaluronateanti-aging ingredientscosmetic products© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Rising environmental awareness drives green consumers to purchase sustainable cosmetics based on natural bioactive compounds. The aim of this study was to deliver Rosa canina L. extract as a botanical ingredient in an anti-aging gel using an eco-friendly approach. Rosehip extract was first characterized in terms of its antioxidant activity through a DPPH assay and ROS reduction test and then encapsulated in ethosomal vesicles with different percentages of ethanol. All formulations were characterized in terms of size, polydispersity, zeta potential, and entrapment efficiency. Release and skin penetration/permeation data were obtained through in vitro studies, and cell viability was assessed using an MTT assay on WS1 fibroblasts. Finally, ethosomes were incorporated in hyaluronic gels (1% or 2% w/v) to facilitate skin application, and rheological properties were studied. Rosehip extract (1 mg/mL) revealed a high antioxidant activity and was successfully encapsulated in ethosomes containing 30% ethanol, having small sizes (225.4 ± 7.0 nm), low polydispersity (0.26 ± 0.02), and good entrapment efficiency (93.41 ± 5.30%). This formulation incorporated in a hyaluronic gel 1% w/v showed an optimal pH for skin application (5.6 ± 0.2), good spreadability, and stability over 60 days at 4 °C. Considering sustainable ingredients and eco-friendly manufacturing technology, the ethosomal gel of rosehip extract could be an innovative and green anti-aging skincare product.The authors are thankful to Sofia Melo Rocha for her contribution to the work. The authors thank the Fundação para a Ciência e Tecnologia, Portugal (UIDB/04138/2020 and UIDP/04138/2020 for iMed.ULisboa, CEECINST/00145/2018 for J. Marto, and CEEC-IND/03143/2017 for L. M. Gonçalves).MDPIRepositório da Universidade de LisboaSallustio, ValentinaFarruggia, GiovannaDi Cagno, Massimiliano PioTzanova, Martina M.Marto, JoanaRibeiro, HelenaGonçalves, LídiaMandrone, ManuelaChiocchio, IlariaCerchiara, TeresaAbruzzo, AngelaBigucci, FedericaLupp, Barbara2023-11-30T12:23:28Z2023-04-252023-11-22T19:50:45Z2023-04-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/61031engSallustio V, Farruggia G, di Cagno MP, Tzanova MM, Marto J, Ribeiro H, et al. Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract. Gels. 2023 Apr 25;9(5):362. Available from: http://dx.doi.org/10.3390/gels9050362cv-prod-340604610.3390/gels9050362info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-04T01:18:26Zoai:repositorio.ul.pt:10451/61031Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:40:48.461200Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract |
| title |
Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract |
| spellingShingle |
Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract Sallustio, Valentina Rosa canina L. extract polyphenols antioxidant activity ethosomal gel sodium hyaluronate anti-aging ingredients cosmetic products |
| title_short |
Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract |
| title_full |
Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract |
| title_fullStr |
Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract |
| title_full_unstemmed |
Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract |
| title_sort |
Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract |
| author |
Sallustio, Valentina |
| author_facet |
Sallustio, Valentina Farruggia, Giovanna Di Cagno, Massimiliano Pio Tzanova, Martina M. Marto, Joana Ribeiro, Helena Gonçalves, Lídia Mandrone, Manuela Chiocchio, Ilaria Cerchiara, Teresa Abruzzo, Angela Bigucci, Federica Lupp, Barbara |
| author_role |
author |
| author2 |
Farruggia, Giovanna Di Cagno, Massimiliano Pio Tzanova, Martina M. Marto, Joana Ribeiro, Helena Gonçalves, Lídia Mandrone, Manuela Chiocchio, Ilaria Cerchiara, Teresa Abruzzo, Angela Bigucci, Federica Lupp, Barbara |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Sallustio, Valentina Farruggia, Giovanna Di Cagno, Massimiliano Pio Tzanova, Martina M. Marto, Joana Ribeiro, Helena Gonçalves, Lídia Mandrone, Manuela Chiocchio, Ilaria Cerchiara, Teresa Abruzzo, Angela Bigucci, Federica Lupp, Barbara |
| dc.subject.por.fl_str_mv |
Rosa canina L. extract polyphenols antioxidant activity ethosomal gel sodium hyaluronate anti-aging ingredients cosmetic products |
| topic |
Rosa canina L. extract polyphenols antioxidant activity ethosomal gel sodium hyaluronate anti-aging ingredients cosmetic products |
| description |
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-11-30T12:23:28Z 2023-04-25 2023-11-22T19:50:45Z 2023-04-25T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/61031 |
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http://hdl.handle.net/10451/61031 |
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eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Sallustio V, Farruggia G, di Cagno MP, Tzanova MM, Marto J, Ribeiro H, et al. Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract. Gels. 2023 Apr 25;9(5):362. Available from: http://dx.doi.org/10.3390/gels9050362 cv-prod-3406046 10.3390/gels9050362 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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