“Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/16530 |
Resumo: | A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides. |
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“Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stabilityAntibacterialAntibiofilmIonic liquidMultidrug resistancePeptideSkin infectionsTyrosinaseWound healingA covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.MDPIRepositório Científico do Instituto Politécnico do PortoGomes, AnaBessa, Lucinda J.Correia, PatríciaFernandes, IvaFerraz, RicardoGameiro, PaulaTeixeira, CátiaGomes, Paula2020-12-04T12:22:02Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/16530engGomes, A., Bessa, L. J., Correia, P., Fernandes, I., Ferraz, R., Gameiro, P., Teixeira, C., & Gomes, P. (2020). “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability. International Journal of Molecular Sciences, 21(17), 6174. https://www.mdpi.com/1422-0067/21/17/617410.3390/ijms21176174info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:03:41Zoai:recipp.ipp.pt:10400.22/16530Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:36:11.125843Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
“Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability |
title |
“Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability |
spellingShingle |
“Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability Gomes, Ana Antibacterial Antibiofilm Ionic liquid Multidrug resistance Peptide Skin infections Tyrosinase Wound healing |
title_short |
“Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability |
title_full |
“Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability |
title_fullStr |
“Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability |
title_full_unstemmed |
“Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability |
title_sort |
“Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability |
author |
Gomes, Ana |
author_facet |
Gomes, Ana Bessa, Lucinda J. Correia, Patrícia Fernandes, Iva Ferraz, Ricardo Gameiro, Paula Teixeira, Cátia Gomes, Paula |
author_role |
author |
author2 |
Bessa, Lucinda J. Correia, Patrícia Fernandes, Iva Ferraz, Ricardo Gameiro, Paula Teixeira, Cátia Gomes, Paula |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Gomes, Ana Bessa, Lucinda J. Correia, Patrícia Fernandes, Iva Ferraz, Ricardo Gameiro, Paula Teixeira, Cátia Gomes, Paula |
dc.subject.por.fl_str_mv |
Antibacterial Antibiofilm Ionic liquid Multidrug resistance Peptide Skin infections Tyrosinase Wound healing |
topic |
Antibacterial Antibiofilm Ionic liquid Multidrug resistance Peptide Skin infections Tyrosinase Wound healing |
description |
A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-04T12:22:02Z 2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/16530 |
url |
http://hdl.handle.net/10400.22/16530 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Gomes, A., Bessa, L. J., Correia, P., Fernandes, I., Ferraz, R., Gameiro, P., Teixeira, C., & Gomes, P. (2020). “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability. International Journal of Molecular Sciences, 21(17), 6174. https://www.mdpi.com/1422-0067/21/17/6174 10.3390/ijms21176174 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1817554570750984192 |