Design of liposomal formulations for cell targeting
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/37612 |
Resumo: | Liposomes have gained extensive attention as carriers for a wide range of drugs due to being both nontoxic and biodegradable as they are composed of substances naturally occurring in biological membranes. Active targeting for cells has explored specific modification of the liposome surface by functionalizing it with specific targeting ligands in order to increase accumulation and intracellular uptake into target cells. None of the Food and Drug Administration-licensed liposomes or lipid nanoparticles are coated with ligands or target moieties to delivery for homing drugs to target tissues, cells or subcellular organelles. Targeted therapies (with or without controlled drug release) are an emerging and relevant research area. Despite of the numerous liposomes reviews published in the last decades, this area is in constant development. Updates urgently needed to integrate new advances in targeted liposomes research. This review highlights the evolution of liposomes from passive to active targeting and challenges in the development of targeted liposomes for specific therapies. |
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Design of liposomal formulations for cell targetingDrug deliveryLigandLiposome characterizationLiposome preparationTargetingStealthScience & TechnologyLiposomes have gained extensive attention as carriers for a wide range of drugs due to being both nontoxic and biodegradable as they are composed of substances naturally occurring in biological membranes. Active targeting for cells has explored specific modification of the liposome surface by functionalizing it with specific targeting ligands in order to increase accumulation and intracellular uptake into target cells. None of the Food and Drug Administration-licensed liposomes or lipid nanoparticles are coated with ligands or target moieties to delivery for homing drugs to target tissues, cells or subcellular organelles. Targeted therapies (with or without controlled drug release) are an emerging and relevant research area. Despite of the numerous liposomes reviews published in the last decades, this area is in constant development. Updates urgently needed to integrate new advances in targeted liposomes research. This review highlights the evolution of liposomes from passive to active targeting and challenges in the development of targeted liposomes for specific therapies.Eugenia Nogueira (SFRH/BD/81269/2011) holds a scholarship from Fundacao para a Ciencia e a Tecnologia (FCT). This study was funded by the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement NMP4-LA-2009-228827 NANOFOL. This study was also supported by FEDER through POFC-COMPETE and by national funds from FCT through the project PEst-C/BIA/UI4050/2014 and the strategic funding of ID/BIO/04469/2013 unit. This work was supported by FCT I.P. through the strategic funding UID/BIA/04050/2013.Elsevier B.V.Universidade do MinhoNogueira, E.Gomes, Andreia CPreto, AnaCavaco-Paulo, Artur20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/37612engNogueira, E.; Gomes, Andreia C.; Preto, Ana; Paulo, Artur Cavaco, Design of liposomal formulations for cell targeting. Colloids and Surfaces B: Biointerfaces, 136, 514-526, 20150927-77650927-776510.1016/j.colsurfb.2015.09.03426454541http://www.journals.elsevier.com/colloids-and-surfaces-b-biointerfaces/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-07T01:22:05Zoai:repositorium.sdum.uminho.pt:1822/37612Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:37:50.339647Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Design of liposomal formulations for cell targeting |
title |
Design of liposomal formulations for cell targeting |
spellingShingle |
Design of liposomal formulations for cell targeting Nogueira, E. Drug delivery Ligand Liposome characterization Liposome preparation Targeting Stealth Science & Technology |
title_short |
Design of liposomal formulations for cell targeting |
title_full |
Design of liposomal formulations for cell targeting |
title_fullStr |
Design of liposomal formulations for cell targeting |
title_full_unstemmed |
Design of liposomal formulations for cell targeting |
title_sort |
Design of liposomal formulations for cell targeting |
author |
Nogueira, E. |
author_facet |
Nogueira, E. Gomes, Andreia C Preto, Ana Cavaco-Paulo, Artur |
author_role |
author |
author2 |
Gomes, Andreia C Preto, Ana Cavaco-Paulo, Artur |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Nogueira, E. Gomes, Andreia C Preto, Ana Cavaco-Paulo, Artur |
dc.subject.por.fl_str_mv |
Drug delivery Ligand Liposome characterization Liposome preparation Targeting Stealth Science & Technology |
topic |
Drug delivery Ligand Liposome characterization Liposome preparation Targeting Stealth Science & Technology |
description |
Liposomes have gained extensive attention as carriers for a wide range of drugs due to being both nontoxic and biodegradable as they are composed of substances naturally occurring in biological membranes. Active targeting for cells has explored specific modification of the liposome surface by functionalizing it with specific targeting ligands in order to increase accumulation and intracellular uptake into target cells. None of the Food and Drug Administration-licensed liposomes or lipid nanoparticles are coated with ligands or target moieties to delivery for homing drugs to target tissues, cells or subcellular organelles. Targeted therapies (with or without controlled drug release) are an emerging and relevant research area. Despite of the numerous liposomes reviews published in the last decades, this area is in constant development. Updates urgently needed to integrate new advances in targeted liposomes research. This review highlights the evolution of liposomes from passive to active targeting and challenges in the development of targeted liposomes for specific therapies. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/37612 |
url |
https://hdl.handle.net/1822/37612 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nogueira, E.; Gomes, Andreia C.; Preto, Ana; Paulo, Artur Cavaco, Design of liposomal formulations for cell targeting. Colloids and Surfaces B: Biointerfaces, 136, 514-526, 2015 0927-7765 0927-7765 10.1016/j.colsurfb.2015.09.034 26454541 http://www.journals.elsevier.com/colloids-and-surfaces-b-biointerfaces/ |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132913903599616 |