Biocompatible gels of chitosan-buriti oil for potential wound healing applications
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/22366 |
Resumo: | The buriti oil (Mauritia flexuosa L.) can be associated with polymeric matrices for biomedical applications. This study aimed to evaluate the e ect of chitosan gel (CG) associated with buriti oil (CGB) as a healing agent. The fatty acids and volatile compounds composition of buriti oil were performed and the composite gels were characterized using FTIR and thermal analysis. Biological tests including antimicrobial, antioxidant, anti-inflammatory and healing e ects were also investigated. Buriti oil is composed of oleic and palmitic acids, and the main volatile compounds were identified. The buriti oil did not show antimicrobial activity, on the other hand, the composite gel (chitosan and oil) proved to be e cient against Staphylococcus aureus and Klebsiella pneumonia at the 10 mg/mL. Similar behavior was observed for antioxidant activity, determined by the -carotene bleaching assay, composite gels presenting higher activity and buriti oil showed anti-inflammatory activity, which may be related to the inhibition of the release of free radicals. Regarding wound healing performed using in vivo testing, the composite gel (CGB) was found to promote faster and complete wound retraction. The results indicated that the gel chitosan–buriti oil has a set of properties that improve its antibacterial, antioxidant and healing action, suggesting that this material can be used to treat skin lesions. |
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Biocompatible gels of chitosan-buriti oil for potential wound healing applicationsBiologicalHealingPolysaccharidesThe buriti oil (Mauritia flexuosa L.) can be associated with polymeric matrices for biomedical applications. This study aimed to evaluate the e ect of chitosan gel (CG) associated with buriti oil (CGB) as a healing agent. The fatty acids and volatile compounds composition of buriti oil were performed and the composite gels were characterized using FTIR and thermal analysis. Biological tests including antimicrobial, antioxidant, anti-inflammatory and healing e ects were also investigated. Buriti oil is composed of oleic and palmitic acids, and the main volatile compounds were identified. The buriti oil did not show antimicrobial activity, on the other hand, the composite gel (chitosan and oil) proved to be e cient against Staphylococcus aureus and Klebsiella pneumonia at the 10 mg/mL. Similar behavior was observed for antioxidant activity, determined by the -carotene bleaching assay, composite gels presenting higher activity and buriti oil showed anti-inflammatory activity, which may be related to the inhibition of the release of free radicals. Regarding wound healing performed using in vivo testing, the composite gel (CGB) was found to promote faster and complete wound retraction. The results indicated that the gel chitosan–buriti oil has a set of properties that improve its antibacterial, antioxidant and healing action, suggesting that this material can be used to treat skin lesions.Maria Onaira Gonçalves Ferreira acknowledges the Coordination for the Improvement of Higher Education Personnel, the Brazilian Ministry of Education, financial support for the scholarship, and other authors acknowledge to National Council for Scientific and Technological Development (CNPQ) and Piauí State Research Support Foundation (FAPEPI).Biblioteca Digital do IPBFerreira, Maria Onaira GonçalvesLima, Idglan SáRibeiro, Alessandra BragaLobo, Anderson O.Rizzo, Marcia SantosOsajima, Josy AnteveliEstevinho, Leticia M.Silva-Filho, Edson C.2018-01-19T10:00:00Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/22366engFerreira, Maria Onaira Gonçalves; Sá Lima, Idglan; Ribeiro, Alessandra Braga; Lobo, Anderson O.; Rizzo, Marcia S.; Osajima, Josy Anteveli; Estevinho, Leticia Miranda; Silva-Filho, Edson C. (2020). Biocompatible gels of chitosan-buriti oil for potential wound healing applications. Materials. ISSN 1996-1944. 13, p. 1-1710.3390/MA13081977info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:50:08Zoai:bibliotecadigital.ipb.pt:10198/22366Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:13:36.268977Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Biocompatible gels of chitosan-buriti oil for potential wound healing applications |
title |
Biocompatible gels of chitosan-buriti oil for potential wound healing applications |
spellingShingle |
Biocompatible gels of chitosan-buriti oil for potential wound healing applications Ferreira, Maria Onaira Gonçalves Biological Healing Polysaccharides |
title_short |
Biocompatible gels of chitosan-buriti oil for potential wound healing applications |
title_full |
Biocompatible gels of chitosan-buriti oil for potential wound healing applications |
title_fullStr |
Biocompatible gels of chitosan-buriti oil for potential wound healing applications |
title_full_unstemmed |
Biocompatible gels of chitosan-buriti oil for potential wound healing applications |
title_sort |
Biocompatible gels of chitosan-buriti oil for potential wound healing applications |
author |
Ferreira, Maria Onaira Gonçalves |
author_facet |
Ferreira, Maria Onaira Gonçalves Lima, Idglan Sá Ribeiro, Alessandra Braga Lobo, Anderson O. Rizzo, Marcia Santos Osajima, Josy Anteveli Estevinho, Leticia M. Silva-Filho, Edson C. |
author_role |
author |
author2 |
Lima, Idglan Sá Ribeiro, Alessandra Braga Lobo, Anderson O. Rizzo, Marcia Santos Osajima, Josy Anteveli Estevinho, Leticia M. Silva-Filho, Edson C. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Ferreira, Maria Onaira Gonçalves Lima, Idglan Sá Ribeiro, Alessandra Braga Lobo, Anderson O. Rizzo, Marcia Santos Osajima, Josy Anteveli Estevinho, Leticia M. Silva-Filho, Edson C. |
dc.subject.por.fl_str_mv |
Biological Healing Polysaccharides |
topic |
Biological Healing Polysaccharides |
description |
The buriti oil (Mauritia flexuosa L.) can be associated with polymeric matrices for biomedical applications. This study aimed to evaluate the e ect of chitosan gel (CG) associated with buriti oil (CGB) as a healing agent. The fatty acids and volatile compounds composition of buriti oil were performed and the composite gels were characterized using FTIR and thermal analysis. Biological tests including antimicrobial, antioxidant, anti-inflammatory and healing e ects were also investigated. Buriti oil is composed of oleic and palmitic acids, and the main volatile compounds were identified. The buriti oil did not show antimicrobial activity, on the other hand, the composite gel (chitosan and oil) proved to be e cient against Staphylococcus aureus and Klebsiella pneumonia at the 10 mg/mL. Similar behavior was observed for antioxidant activity, determined by the -carotene bleaching assay, composite gels presenting higher activity and buriti oil showed anti-inflammatory activity, which may be related to the inhibition of the release of free radicals. Regarding wound healing performed using in vivo testing, the composite gel (CGB) was found to promote faster and complete wound retraction. The results indicated that the gel chitosan–buriti oil has a set of properties that improve its antibacterial, antioxidant and healing action, suggesting that this material can be used to treat skin lesions. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-19T10:00:00Z 2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/22366 |
url |
http://hdl.handle.net/10198/22366 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ferreira, Maria Onaira Gonçalves; Sá Lima, Idglan; Ribeiro, Alessandra Braga; Lobo, Anderson O.; Rizzo, Marcia S.; Osajima, Josy Anteveli; Estevinho, Leticia Miranda; Silva-Filho, Edson C. (2020). Biocompatible gels of chitosan-buriti oil for potential wound healing applications. Materials. ISSN 1996-1944. 13, p. 1-17 10.3390/MA13081977 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799135412575272960 |